Results 271 to 280 of about 6,673,815 (394)

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

open access: yesExperimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento   +2 more
wiley   +1 more source

A simulation study on the role of mitochondria‐sarcoplasmic reticulum Ca2+ interaction in cardiomyocyte energetics during exercise

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend An integrated model of human ventricular myocyte with excitation‐contraction‐energetics coupling was created to systematically analyse the contribution of Ca2+ regulation of mitochondrial enzymes to cardiomyocyte functions during workload transition; i.e. exercise.
Ayako Takeuchi, Satoshi Matsuoka
wiley   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Parker Samuel   +2 more
wiley   +1 more source

Cardiac troponin complexes and fragments: potential targets for improved clinical performance

open access: hybrid
Sander A.J. Damen   +6 more
openalex   +1 more source

Mobility change of troponin I-133 region in troponin complex induced by calcium

open access: bronze, 2003
Tomoki Aihara   +4 more
openalex   +2 more sources

Determining properties of human‐induced pluripotent stem cell‐derived cardiomyocytes using spatially resolved electromechanical metrics

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger   +4 more
wiley   +1 more source

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