Results 291 to 300 of about 6,764,388 (368)

Seipin‐Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu, Junxia Zhang, Yusi Chen, Geng Shen, Yufei Han, Zihao Zhou, Jinxuan Chen, Xuya Kang, Huilin Qu, Jiaxin Duanmu, Haibao Shang, Yingjia Li, Wei Huang, Yan Zhang   +13 more
wiley   +1 more source

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

Advanced Science, Volume 13, Issue 1, 5 January 2026.
An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu, Peng Qu, Jiao Shi, Tingting Liang, Yao Gu, Xue Li, Cui Ma, Danyang Zhao, Feila Liu, Qi Liang, Panke Cheng, Qian Lei   +11 more
wiley   +1 more source

Correlation of Clinical and Laboratory Features of Multisystem Inflammatory Syndrome in Children with Echocardiographic Findings. [PDF]

Medicina (Kaunas)
Barišić N, Vijatov-Đurić G, Milanović B, Vorgučin I, Koprivšek K, Milojković M, Ležakov O, Stojanović V.   +7 more
europepmc   +1 more source

Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy

Advanced Science, Volume 13, Issue 1, 5 January 2026.
This review examines engineered fever therapy (EFT) as a novel cancer treatment, harnessing fever's immunomodulatory effects to enhance systemic immune responses. It explores molecular mechanisms, advances in nanotechnology‐driven thermal immunotherapy, and a bioengineered framework for precise, safe fever induction. The paper evaluates EFT's potential
Yang Li, Fulong Man, Jianwei Cheng, Li Chen, Yongyong Li, Haiqing Dong   +5 more
wiley   +1 more source

The Role of High-Sensitivity Cardiac Troponin and Ischemia-Modified Albumin in Patients with Lower Extremity Peripheral Arterial Disease. [PDF]

Int J Mol Sci
Boc V, Blinc A, Boc A.
europepmc   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

Special Issue: Emerging Topics in Metal Complexes: Pharmacological Activity, 2nd Edition. [PDF]

Int J Mol Sci
Ścibior A, Aureliano M, Llopis J.
europepmc   +1 more source

Tissue‐Specific Extraction and Structural Elucidation of Actin‐Tropomyosin‐Myosin Complexes from Human and Rodent

Aggregate, Volume 7, Issue 1, January 2026.
We developed a general tissue‐extraction strategy that directly purifies native F‐actin and actin–tropomyosin–myosin (ATM) complexes from human and rodent muscles for cryo‐EM. Near‐atomic structures, including an HCM R404Q mouse model, reveal how a disease myosin mutation remodels ATM assembly and alters myosin conformation at the actin interface ...
Danni Li, Qinyue Zhao, Youqi Tao, Shiran Lv, Wanbing Zhao, Yunxia Li, Xingyu Xiong, Zhizhi Wang, Wenqing Xu, Yaoyang Zhang, Cong Liu, Weidong Le, Wenyan Kang, Dan Li, Qin Cao, Bin Dai   +15 more
wiley   +1 more source

Early Recognition of Giant Cell Myocarditis in a Patient With Fascicular Ventricular Tachycardia. [PDF]

JACC Case Rep
Sacher AC, Ahmed R, Kung A, Pillai K, Kahlam J.   +4 more
europepmc   +1 more source