Results 271 to 280 of about 153,000 (334)

Impact of High Intensity Contact Physical Activity During a Match on Echocardiographic Parameters and High-Sensitivity Troponin I in Competitive Rugby Players. [PDF]

J Clin Med
Radic P, Bulj N, Car S, Cancarevic M, Sikic A, Delic-Brkljacic D, Pavlov M, Babic Z.   +7 more
europepmc   +1 more source

Impact of Food and Drug Administration Regulations on the Performance of Guideline-Recommended Pathways With an Approved Point-of-Care High-Sensitivity Cardiac Troponin I Assay. [PDF]

J Am Heart Assoc
Koechlin L, Boeddinghaus J, Lopez-Ayala P, Bianchi CL, Nestelberger T, Wildi K, Miró Ò, Christ M, Rentsch K, Mahfoud F, Mueller C, APACE investigators †.   +11 more
europepmc   +1 more source

Proteomic Profiling Informs Mechanisms of Esophageal Adenocarcinoma Inhibition by Cranberry Proanthocyanidins

Molecular Nutrition &Food Research, EarlyView.
In this study we utilized proteomic profiling to investigate mechanisms linked to the cancer‐inhibitory effect of cranberry proanthocyanidins (CPACs) on reflux‐induced esophageal adenocarcinoma in a rat model. The results indicate that CPAC inhibits cancer through targeting multiple hallmarks of cancer known to be dysregulated in progression to ...
Yun Zhang, Michelle Lee, Erika de Jesus, Katherine Weh, Connor Howard, Henriette Remmer, Amy B. Howell, Laura A. Kresty   +7 more
wiley   +1 more source

Enhancing lateral flow immunoassay performance for cardiac troponin I detection with pore-size tailored silica nanoparticles and smartphone-based "AdaptiScan" analysis. [PDF]

Front Bioeng Biotechnol
Ye S, Xu C, Li H, Feng S, Wang Y, Gao F.
europepmc   +1 more source

A Phase 1, Double‐Blind, Placebo‐Controlled Trial of Sevasemten (EDG‐5506), a Selective Modulator of Fast Skeletal Muscle Contraction, in Healthy Volunteers and Adults With Becker Muscular Dystrophy

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Sevasemten (EDG‐5506) is an orally administered, investigational small molecule that selectively modulates fast muscle fiber contraction by inhibiting fast myosin ATPase. This study assessed the safety, tolerability, and pharmacokinetics (PK)/pharmacodynamics (PD) of sevasemten in healthy adult volunteers (HVs) and adults ...
Joanne Donovan, Jeffrey A. Silverman, Ben Barthel, Michael DuVall, Molly Madden, James MacDougall, Nicole Rempel Kilburn, Abby Bronson, Marc Evanchik, Gilad Gordon, Kevin Koch, Alan J Russell   +11 more
wiley   +1 more source

Serum Cardiac Troponin T Levels as a Therapy Response Marker in Tofersen‐Treated ALS

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Cardiac troponin T (cTnT) levels are elevated in the majority of persons with amyotrophic lateral sclerosis (ALS) and increase over time. Neurofilament light chain (NfL) is an established therapy response biomarker in ALS as superoxide dismutase1 (SOD1)‐ALS patients treated with the antisense oligonucleotide tofersen show a ...
Sarah Bernsen, Rachel Fabian, Yasemin Koc, Peggy Schumann, Peter Körtvélyessy, Sergio Castro‐Gomez, Thomas Meyer, Patrick Weydt   +7 more
wiley   +1 more source

Post‐COVID‐19 condition: clinical phenotypes, pathophysiological mechanisms, pathology, and management strategies

The Journal of Pathology, EarlyView.
Abstract Post‐COVID‐19 condition (PCC), also known as long COVID, is a complex multiple organ system condition that can develop and persist for months after acute COVID‐19. PCC encompasses a wide range of symptoms, resulting in heterogeneous clinical manifestations. These manifestations likely arise from diverse underlying pathophysiological mechanisms,
Larissa E Vlaming‐van Eijk, Guolu Tang, Arno R Bourgonje, Wilfred F A den Dunnen, Jan‐Luuk Hillebrands, Harry van Goor   +5 more
wiley   +1 more source

Case Report: Restrictive cardiomyopathy due to a rare mutation in troponin I gene (TNNI3) in a patient. [PDF]

Front Cardiovasc Med
Deng L, Luo L, Zhang M, Guo C, Liu K.
europepmc   +1 more source

Transforming Niclosamide through Nanotechnology: A Promising Approach for Long COVID Management

Small, EarlyView.
This review highlights the transformation of niclosamide, a repurposed drug, through molecular science strategies to overcome its pharmacokinetic limitations. Emphasizing novel nanohybrid technologies and delivery platforms, the article explores their therapeutic potential in targeting the complex pathophysiology of long COVID, paving the way for ...
Sanoj Rejinold N, Goeun Choi, Geun‐woo Jin, Jin‐Ho Choy   +3 more
wiley   +1 more source

Elevated Cardiac Troponin I Level Associated to Cardiac Dysfunction in Burned Patients. [PDF]

J Burn Care Res
Segura C, Golovko G, Obias I, Shah S, El Ayadi A, Wolf S, Song J.   +6 more
europepmc   +1 more source