Results 71 to 80 of about 153,000 (334)

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source

Which diagnostic tests are most useful in a chest pain unit protocol? [PDF]

, 2005
Background The chest pain unit (CPU) provides rapid diagnostic assessment for patients with acute, undifferentiated chest pain, using a combination of electrocardiographic (ECG) recording, biochemical markers and provocative cardiac testing.
Angelini, K., Arnold, J., Goodacre, S., Locker, T., Morris, F.   +4 more
core   +3 more sources

Label‐Free Single‐Molecule Immunoassay

Advanced Science, EarlyView.
Label‐free single‐molecule immunoassay (LFSMiA) enables ultra‐sensitive and wide dynamic range protein detection in whole blood samples. LFSMiA features real‐time single‐molecule imaging by plasmonic scattering microscopy, background reduction by a 2‐step sandwich assay, minimizing matrix effect by dynamic tracking of single binding events, and ...
Xiaoyan Zhou, Chao Chen, Shuang Zhou, Guangzhong Ma, Mohammad Javad H. N. Chemerkouh, Christine L. H. Snozek, Eric H. Yang, Jiapei Jiang, Brandyn Braswell, Zijian Wan, Xinyu Zhou, Shaopeng Wang   +11 more
wiley   +1 more source

Prognostic prediction of troponins in cardiac myxoma: case study with literature review

Brazilian Journal of Cardiovascular Surgery, 2015
Objective:It was supposed that troponins in cardiac myxoma patients might be in a same fashion as in the conditions without myocardial injury. In order to verify this hypothesis, troponins in cardiac myxoma patients were discussed by presenting a ...
Shi-Min Yuan
doaj   +1 more source

Assessment of the Relationship between Mortality and Troponin I Levels in Hospitalized Patients with the Novel Coronavirus (COVID-19)

Medicina, 2020
Background and Objectives: This study aimed to evaluate the relationship between mortality and cardiac laboratory findings in patients who were hospitalized after a positive PCR for COVID-19 infection.
Sinem Özyılmaz, Esra Ergün Alış, Emrah Ermiş, Samir Allahverdiyev, Hakan Uçar   +4 more
doaj   +1 more source

Can troponin-I be used as an independent predictor of cardiac dysfunction after supraventricular tachycardia in children with structural normal heart? [PDF]

Vojnosanitetski Pregled, 2019
Introduction. Elevated cardiac troponin gives excellent accuracy in the identification of myocardial damage in children, but it can also be elevated in a series of other diseases. Case report.
Simović Aleksandra M., Tanasković-Nestorović Jelena M., Knežević Sanja M., Vuletić Biljana P., Stojković Anđelka K., Jeremić Dejan M., Jovanović Milan, Vulović Maja   +7 more
doaj   +1 more source

High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis [PDF]

, 2014
Aims: High-sensitivity cardiac troponin I (cTnI) assays hold promise in detecting the transition from hypertrophy to heart failure in aortic stenosis.
A. L. Hunter, A. Maria Choy, A. S. V. Shah, C. C. Lang, C. W. L. Chin, Cowell, D. A. McAllister, D. E. Newby, Dweck, Dweck, F. E. Strachan, J. P. Langrish, M. R. Dweck, Messroghli, Mills, N. A. Boon, N. L. Mills, Nkomo, Rosjo, S. Alam, S. Joanna Cowell, S. Walker, Thygesen, Wieczorek   +23 more
core   +4 more sources

Cardiac Troponin T and Troponin I in the General Population [PDF]

Circulation, 2019
Background: There is great interest in widening the use of high-sensitivity cardiac troponins for population cardiovascular disease (CVD) and heart failure screening. However, it is not clear whether cardiac troponin T (cTnT) and troponin I (cTnI) are equivalent measures of risk in this setting. We aimed to compare and contrast
Charles Boachie, Alex McConnachie, Caroline Hayward, Mark Woodward, Mark Woodward, David A. McAllister, Anoop S V Shah, Sandosh Padmanabhan, Nicholas L. Mills, Archie Campbell, Andrew Briggs, Claire E. Welsh, David J. Porteous, Naveed Sattar, Paul Welsh, David Preiss   +15 more
openaire   +5 more sources

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source