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Molecular and Cellular Biochemistry, 2004
Several striated muscle myopathies have been directly linked to mutations in contractile and associated proteins. Troponin T (TnT) is one of the three subunits that form troponin (Tn) which together with tropomyosin is responsible for the regulation of striated muscle contraction.
Aldrin V, Gomes +3 more
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Several striated muscle myopathies have been directly linked to mutations in contractile and associated proteins. Troponin T (TnT) is one of the three subunits that form troponin (Tn) which together with tropomyosin is responsible for the regulation of striated muscle contraction.
Aldrin V, Gomes +3 more
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The Lancet, 1998
The diagnosis of heart contusion during medicolegal necropsies is difficult because attempted reanimation by cardiac massage, defibrillation, or both can cause subepicardial, endocardial, and transmural haemorrhage. Macroscopically it is not possible to say whether noninvasive trauma of the chest took place during life, at death, or after death ...
J, Dressler +3 more
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The diagnosis of heart contusion during medicolegal necropsies is difficult because attempted reanimation by cardiac massage, defibrillation, or both can cause subepicardial, endocardial, and transmural haemorrhage. Macroscopically it is not possible to say whether noninvasive trauma of the chest took place during life, at death, or after death ...
J, Dressler +3 more
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Biochemistry, 1984
We have studied the interaction between troponin and tropomyosin by means of a fluorescent probe, N-(1- anilinonaphth -4-yl)maleimide (ANM), attached to the cysteine-190 residues of tropomyosin. The binding of troponin and troponin T to ANM-tropomyosin produces substantial increases in the label fluorescence.
E P, Morris, S S, Lehrer
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We have studied the interaction between troponin and tropomyosin by means of a fluorescent probe, N-(1- anilinonaphth -4-yl)maleimide (ANM), attached to the cysteine-190 residues of tropomyosin. The binding of troponin and troponin T to ANM-tropomyosin produces substantial increases in the label fluorescence.
E P, Morris, S S, Lehrer
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2021
Cardiovascular diseases are the leading cause of death worldwide. Most of these deaths are due to heart attacks. Rapid diagnosis and intervention is essential to improve the outcome and prognosis of heart attack patients. Though a small portion of suspected heart attack patients can immediately be diagnosed by an electrocardiogram, most rely on (serial)
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Cardiovascular diseases are the leading cause of death worldwide. Most of these deaths are due to heart attacks. Rapid diagnosis and intervention is essential to improve the outcome and prognosis of heart attack patients. Though a small portion of suspected heart attack patients can immediately be diagnosed by an electrocardiogram, most rely on (serial)
openaire +2 more sources
The binding sites of rabbit skeletal troponin-I on troponin-T
Canadian Journal of Biochemistry, 1980Various fragments derived from rabbit skeletal muscle troponin-T (Tn-T) by chemical and (or) proteolytic cleavage were mixed with whole troponin-I (Tn-I) and applied to a Sephadex G-75 gel filtration column in order to determine the binding site of Tn-I on Tn-T. This site of interaction was found to span two distinct regions of Tn-T.
J R, Pearlstone, L B, Smillie
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Troponin T fragments: Physical properties and binding to troponin C
Canadian Journal of Biochemistry, 1978Fragments derived from rabbit skeletal troponin T (Tn-T) were tested for binding on a troponin C (Tn-C) – Sepharose affinity column in order to locate the binding site of Tn-C on Tn-T. The COOH-terminal fragments P2 (residues 159–209) and B2 (residues 206–258) were found to bind most strongly, confirming the earlier proposal (Pearlstone, J.
J R, Pearlstone, L B, Smillie
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Biofizika, 2001
The method of fluorescence quenching was used to experimentally determine the distribution of tryptophan residues in molecules of troponin T, troponin T-troponin I complexes, and alpha-actinin. Iodide and cesium ions, and acrylamide were used as quenchers.
A G, Gvritishvili +6 more
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The method of fluorescence quenching was used to experimentally determine the distribution of tryptophan residues in molecules of troponin T, troponin T-troponin I complexes, and alpha-actinin. Iodide and cesium ions, and acrylamide were used as quenchers.
A G, Gvritishvili +6 more
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Structure of tropomyosin-troponin T cocrystals
Journal of Muscle Research and Cell Motility, 1988Crystals formed from a mixture of tropomyosin and troponin T have an open double-stranded lattice structure with a diamond-shaped repeat. In some regions the appearance in electron micrographs of negatively stained specimens changes from this double-diamond lattice to a more condensed banded crystal form.
H J, Carr, E J, O'Brien, E P, Morris
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