Results 61 to 70 of about 112,735 (309)

Targeted Anti‐IL‐1 Immunomodulatory Therapy in Pediatric Onset PPP1R13L‐Related Arrhythmogenic Cardiomyopathy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg, Savannah Coppersmith, Owen Merritt, Amer Heider, Adam Helms, Thomas Michniacki, Jack Luxford, Sarah Josephi‐Taylor, Philip Roberts, Joshua Meisner   +9 more
wiley   +1 more source

Interleukin‐2 Deprived State of Regulatory T cells and Their Recovery by Low‐Dose Interleukin‐2 in Patients With Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Objective Regeneration and expansion of Treg by low‐dose interleukin‐2 (IL‐2) therapy is considered a potential treatment strategy for a wide range of autoimmune diseases. To provide a pathophysiologically‐based rationale for low‐dose IL‐2 therapy, we investigated whether reversible defects in the Treg–IL‐2 axis emerge in inflammatory myopathies ...
Justus Ohmes, Luisa R. Monne, Sara Comdühr, Fynn Gerlach, Hanna Grasshoff, Alexander Dübbers, Antje Müller, Alexander Scheffold, Gabriela Riemekasten, Reza Akbarzadeh, Jens Y. Humrich   +10 more
wiley   +1 more source

Nanoparticulate Copper Cluster-Mediated Biosensing of Cardiac Biomolecular Markers

Biosensors
Being a leading cause of death, heart diseases across the globe need special attention to enable early diagnosis. Metal nanoparticle-mediated biosensors are useful clinical tools for the early detection of bio-analytes. The size-dependent surface plasmon
Lakshmi V. Nair, Jarred Wheeler, Yaelyn Ha, Kimberly M. Jones, Jesse Jones, Vinoy Thomas   +5 more
doaj   +1 more source

Combined determination of highly sensitive troponin T and copeptin for early exclusion of acute myocardial infarction: first experience in an emergency department of a general hospital

, 2011
Ulrich Lotze1, Holger Lemm2, Anke Heyer2, Karin Müller31Department of Internal Medicine, German Red Cross Hospital Sondershausen, Sondershausen, 2Department of Internal Medicine, 3Department of Laboratory Medicine, Saale-Unstrut Hospital Naumburg ...
Mueller, null Mueller, null Lemm, null Heyer, Ulrich Lotze, Lemm, Lotze U, Heyer   +7 more
core   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

LITERATURE REVIEW: PROFIL PEMERIKSAAN CKMB ,TROPONIN I, TROPONIN T dan High Sensitivity TROPONIN PADA PENDERITA INFARK MIOKARD AKUT (IMA) [PDF]

, 2021
Infark miokard akut (IMA) merupakan salah satu penyebab utama kematian di dunia. Penyakit ini adalah gangguan aliran darah ke jantung yang menyebabkan sel otot jantung mati atau otot jantung tidak mendapatkan cukup darah serta oksigen ...
Aji Bagus Widyantara, M.,M.R, Tika Annisa Wandari, 1711304016, Titin Aryani, S.Si., M.Sc   +2 more
core  

Machine Learning Models of Phase Contrast Images Predict Efficiency of Human Pluripotent Stem Cell Differentiation to Cardiomyocytes

Biotechnology and Bioengineering, EarlyView.
Human pluripotent stem cells were differentiated to cTnT+ cardiomyocytes and imaged throughout the process using phase contrast. We predicted differentiation efficiency (cTnT+ area) from phase contrast and compared model performance with a live‐cell cTnT‐GFP reporter.
Austin K. Feeney, Yaniv Ovadia, Aaron D. Simmons, Christian Elabd, Claire J. Peplinski, Frank Li, Sean P. Palecek   +6 more
wiley   +1 more source

Diagnostic Value of Troponin I and T to Predict Mortality in Patients Undergoing Hemodialysis

Archives of Anesthesia and Critical Care, 2018
Background: There is no known biomarker to predict the mortality risk in patients undergoing dialysis in the intensive care unit (ICU). Therefore, the current study aimed to determine the diagnostic value of troponin I and T in this respect.
Seyed Taghi Hashemi, Babak Alikiaii, Samira Ghasemi   +2 more
doaj  

The real-world rate of falsely reduced cardiac troponin T tests

Journal of Laboratory Medicine
Measurement of cardiac troponin T (cTnT) plays a crucial role in the diagnosis of acute myocardial infarction (AMI). Due to its extremely high sensitivity, the high sensitive troponin T test is vulnerable to interfering antibodies.
Schmetzer Oliver, Kroupis Christos, Haliassos Alexander, Schlatterer Kathrin   +3 more
doaj   +1 more source

Drug-Induced Rhabdomyolysis with Elevated Cardiac Troponin T

Case Reports in Medicine, 2015
The essential role of cardiac troponin in the diagnosis of acute myocardial infarction has led to the development of high-sensitivity assays, which are able to detect very small amounts of myocardial necrosis.
Gro Egholm, Manan Pareek
doaj   +1 more source