FEBS Open Bio, Volume 14, Issue 10, Page 1718-1730, October 2024.The Bordetella genome contains a large family of periplasmic binding proteins (PBPs) called Bugs, whose functions are largely unknown. We show that Bug27 and Bug69 have high affinity for quinolinate, a precursor in NAD biosynthesis. Sequence analysis and molecular docking suggest a link between these proteins and NAD metabolism, highlighting their role
Leonardo Sorci +4 more
wiley +1 more source
Molecular Distributions in Gene Regulatory Dynamics [PDF]
, 2010 We show how one may analytically compute the stationary density of the distribution of molecular constituents in populations of cells in the presence of noise arising from either bursting transcription or translation, or noise in degradation rates ...
Acar +55 more
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Leveraging the Power of Enzymes in Engineered Dead and Living Materials
Advanced Functional Materials, Volume 34, Issue 44, October 29, 2024.Insights gained during the design of functional enzyme materials have immense potential to supercharge the nascent Engineered Living Material (ELM) field. In this review, these impressive material design strategies are unpacked and contrasted with the enzyme‐control systems used by microorganisms.
Mark R. Shannon +2 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Abstracting Asynchronous Multi-Valued Networks: An Initial Investigation [PDF]
, 2011 Multi-valued networks provide a simple yet expressive qualitative state based modelling approach for biological systems. In this paper we develop an abstraction theory for asynchronous multi-valued network models that allows the state space of a model to
Steggles, L. Jason
core +1 more source
Genome-Wide Study of mRNA Degradation and Transcript Elongation in Escherichia coli [PDF]
, 2015 An essential part of gene expression is the coordination of RNA synthesis and degradation, which occurs in the same cellular compartment in bacteria.
Chen, Huiyi +3 more
core +2 more sources
Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits. [PDF]
, 2017 In prokaryotes, RNA polymerase and ribosomes can bind concurrently to the same RNA transcript, leading to the functional coupling of transcription and translation.
Blaha, Gregor M +9 more
core +1 more source
Elucidation of Directionality for Co-Expressed Genes: Predicting Intra-Operon Termination Sites
, 2005 We present a novel framework for inferring regulatory and sequence-level information from gene co-expression networks. The key idea of our methodology is the systematic integration of network inference and network topological analysis approaches for ...
A. Gupta +22 more
core +1 more source
Identification of a novel retroviral gene unique to human immunodeficiency virus type 2 and simian immunodeficiency virus SIVMAC [PDF]
, 1988 Human and simian immunodeficiency-associated retroviruses are extraordinarily complex, containing at least five genes, tat, art, sor, R, and 3' orf, in addition to the structural genes gag, pol, and env.
Hahn, Beatrice H. +7 more
core
Nucleotide sequence of the luxA gene of Vibrio harveyi and the complete amino acid sequence of the alpha subunit of bacterial luciferase [PDF]
, 1985 The nucleotide sequence of the 1.85-kilobase EcoRI fragment from Vibrio harveyi that was cloned using a mixed-sequence synthetic oligonucleotide probe (Cohn, D. H., Ogden, R. C., Abelson, J. N., Baldwin, T. O., Nealson, K. H., Simon, M.
Baldwin, Thomas O. +6 more
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