Microbiology Spectrum, 2023 Chlamydia, comprising several human and zoonotic pathogens, is a genus of the conserved bacterial phylum Chlamydiota. Their obligate intracellular niche serves as a barrier for natural genetic exchange via horizontal gene transfer (HGT), and further ...
Hanna Marti +6 more
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Dissecting the role of critical residues and substrate preference of a Fatty Acyl-CoA Synthetase (FadD13) of Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2009 Newly emerging multi-drug resistant strains of Mycobacterium tuberculosis (M.tb) severely limit the treatment options for tuberculosis (TB); hence, new antitubercular drugs are urgently needed.
Garima Khare +5 more
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What makes ribosome-mediated transcriptional attenuation sensitive to amino acid limitation?
PLoS Computational Biology, 2005 Ribosome-mediated transcriptional attenuation mechanisms are commonly used to control amino acid biosynthetic operons in bacteria. The mRNA leader of such an operon contains an open reading frame with "regulatory" codons, cognate to the amino acid that ...
Johan Elf, Måns Ehrenberg
doaj +2 more sources
Clinical Persistence of Chlamydia trachomatis Sexually Transmitted Strains Involves Novel Mutations in the Functional αββα Tetramer of the Tryptophan Synthase Operon. [PDF]
, 2019 Clinical persistence of Chlamydia trachomatis (Ct) sexually transmitted infections (STIs) is a major public health concern. In vitro persistence is known to develop through interferon gamma (IFN-γ) induction of indoleamine 2,3-dioxygenase (IDO), which ...
Dean, Deborah +4 more
core +1 more source
Release of transcript and template during transcription termination at the trp operon attenuator.
Journal of Biological Chemistry, 1983 We studied release of trp leader RNA and trp template DNA from RNA polymerase during transcription termination at the attenuator of the trp operon of Escherichia coli. Preliminary evidence had suggested that a stable ternary complex was formed at the trp attentuator.
Vivian Berlin, Charles Yanofsky
openalex +4 more sources
mBio, 2019 TrpY from Methanothermobacter thermautotrophicus is a regulator that inhibits transcription of the Trp biosynthesis (trp) operon. Here, we show that the TrpY homolog in Thermococcus kodakarensis is not involved in such regulation.
Yasuyuki Yamamoto +3 more
doaj +1 more source
Stochastic switching induced adaptation in a starved Escherichia coli population. [PDF]
PLoS ONE, 2011 Population adaptation can be determined by stochastic switching in living cells. To examine how stochastic switching contributes to the fate decision for a population under severe stress, we constructed an Escherichia coli strain crucially dependent on ...
Yoshihiro Shimizu +4 more
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The computer revolution in science: steps towards the realization of computer-supported discovery environments [PDF]
, 1997 The tools that scientists use in their search processes together form so-called discovery environments. The promise of artificial intelligence and other branches of computer science is to radically transform conventional discovery environments by ...
Jong, Hidde de, Rip, Arie
core +2 more sources
Molecular Basis for the Ribosome Functioning as an L-Tryptophan Sensor
Cell Reports, 2014 Elevated levels of the free amino acid L-tryptophan (L-Trp) trigger expression of the tryptophanase tnaCAB operon in E. coli. Activation depends on tryptophan-dependent ribosomal stalling during translation of the upstream TnaC peptide.
Lukas Bischoff +2 more
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Transcription of the trp operon in Lactococcus lactis is controlled by antitermination in the leader region [PDF]
Microbiology, 1998 The regulatory functions of the leader region preceding the Lactococcus lactis trp operon have been studied by mutagenesis analysis. This leader presents striking similarity to ‘T-box’ leaders found upstream of many Gram-positive aminoacyl-tRNA synthetase genes and some amino acid biosynthesis operons, which are controlled by antitermination through ...
Frenkiel, H. +3 more
openaire +4 more sources