Results 51 to 60 of about 16,700 (189)

First‐in‐class inhibitors of SbnA reduce siderophore production in Staphylococcus aureus

The FEBS Journal, Volume 292, Issue 17, Page 4650-4674, September 2025.
The production of the iron‐chelating compound staphyloferrin B by the most invasive S. aureus strains is crucial for colonization, virulence, and survival in the host. Staphyloferrin B biosynthesis is carried out by eight enzymes, the Sbn system, that offer an appealing source of potential targets for the development of antimicrobials.
Sarah Hijazi, Monica Cozzi, Somayeh Asgharpour, Omar De Bei, Serena Faggiano, Francesco Marchesani, Luca Ronda, Marialaura Marchetti, Eleonora Gianquinto, Mariacristina Failla, Gauthier Trèves, Loretta Lazzarato, Francesca Spyrakis, Barbara Campanini, Emanuela Frangipani, Stefano Bettati   +15 more
wiley   +1 more source

Dermatologically Tested Apple‐Derived Extracellular Vesicles: Safety, Anti‐Aging, and Soothing Benefits for Skin Health

Journal of Cosmetic Dermatology, Volume 24, Issue 7, July 2025.
ABSTRACT Extracellular vesicles (EVs) derived from plant sources, particularly apple‐derived vesicles (ADVs), have gained interest for their biocompatibility and bioactive properties in cosmetic, dermatological, and regenerative medicine applications.
Lucia Sileo, Maria Pia Cavaleri, Luca Lovatti, Giuseppe Pezzotti, Letizia Ferroni, Barbara Zavan   +5 more
wiley   +1 more source

Identification of the CRP regulon using in vitro and in vivo transcriptional profiling [PDF]

, 2004
The Escherichia coli cyclic AMP receptor protein (CRP) is a global regulator that controls transcription initiation from more than 100 promoters by binding to a specific DNA sequence within cognate promoters.
Constantinidou, Chrystala, Hobman, Jon L., Minchin, Stephen D., Zheng, Dongling   +3 more
core   +2 more sources

Mechanism of 3-Methylanthranilic Acid Derepression of the Tryptophan Operon in \u3cem\u3eEscherichia coli\u3c/em\u3e [PDF]

, 1970
3-Methylanthranilic acid (3MA) inhibits growth and causes derepression of the tryptophan biosynthetic enzymes in wild-type strains of Escherichia coli. Previous reports attributed this effect to an inhibition of the conversion of 1-(o-carboxyphenylamino)-
Held, William A., Smith, Oliver H.
core   +1 more source

Engineered Living Energy Materials

Interdisciplinary Materials, Volume 4, Issue 3, Page 412-455, May 2025.
Engineered living energy materials (ELEMs) are nascent research frontier for enabling sustainable energy conversion and storage. These materials exhibit unique characteristics such as self‐regeneration, biodegradability, environmental response, and evolutionary adaptability. This paper overviews different energy conversion bio‐modules, summarizes their
Xinyi Yuan, Haiyi Xu, Xingwu Liu, Jicong Zhang, Jing Li, Qianyi Liang, Bolin An, Giuseppe Maria Paternò, Minyue Zhang, Yuqing Tang, Chen Zhang, Dake Xu, Chao Zhong, Ke Li, Xinyu Wang   +14 more
wiley   +1 more source

Expression of divIB of Bacillus subtilis during vegetative growth [PDF]

, 1994
Expression of the division initiation gene, divIB, of Bacillus subtilis vegetative growth was examined. lacZ fusion studies and transcription start point mapping have established that a sigma A promoter proximal to divIB is utilized in vivo.
Aiba H., Aubenton Carafa Y., Band L., Beall B., Beall B., Beall B., Callister H., Daniel R. A., Errington J., Errington J., Ferrari F. A., Gholamhoseinian A., Gonzy-Treboul G., Harry E. J., Harry E. J., Henriques A. O., Horinouchi S., Jacob S., Karmazyn-Campelli C., Lutkenhaus J., Malo M. S., Malo M. S., Malo M. S., Neff N. F., Newton A., Shimotsu H., Wiggs J., Wu J., Zuber P.   +28 more
core   +2 more sources

The Biarylitides: Understanding the Structure and Biosynthesis of a Fascinating Class of Cytochrome P450 Modified RiPP Natural Products

ChemBioChem, Volume 26, Issue 7, April 1, 2025.
The biarylitides are fascinating RiPP natural products with small core peptides and diverse peptide crosslinks performed by cytochrome P450 enzymes. Here, we address the discovery and diversity of the biarylitides, methods to analyse these constrained cyclic peptides, the structures of the biarylitide P450 enzymes and address alternate catalytic ...
Leo Padva, Jemma Gullick, Laura J. Coe, Mathias H. Hansen, James J. De Voss, Max Crüsemann, Max J. Cryle   +6 more
wiley   +1 more source

A naturally occurring standalone TrpB enzyme provides insights into allosteric communication within tryptophan synthase

Protein Science, Volume 34, Issue 4, April 2025.
Abstract Allosteric regulation of catalytic activity is a widespread property of multi‐enzyme complexes. The tryptophan synthase is a prototypical allosteric enzyme where the constituting α (TrpA) and β (TrpB) subunits mutually activate each other in a manner that is incompletely understood.
Thomas Kinateder, Lukas Drexler, Cristina Duran, Sílvia Osuna, Reinhard Sterner   +4 more
wiley   +1 more source

Regulation of the \u3cem\u3eEscherichia coli\u3c/em\u3e Tryptophan Operon by Early Reactions in the Aromatic Pathway [PDF]

, 1970
7-Methyltryptophan (7MT) or compounds which can be metabolized to 7MT, 3-methylanthranilic acid (3MA) and 7-methylindole, cause derepression of the trp operon through feedback inhibition of anthranilate synthetase. Tyrosine reverses 3MA or 7-methylindole
Held, William A., Smith, Oliver H.
core   +1 more source

Genetic Basis of Tetracycline Resistance in Bifidobacterium animalis subsp lactis [PDF]

, 2010
All strains of Bifidobacterium animalis subsp. lactis described to date show medium level resistance to tetracycline. Screening of 26 strains from a variety of sources revealed the presence of tet(W) in all isolates. A transposase gene upstream of tet(W)
Florez, A.B., Gueimonde, M., Hoek, A.H.A.M., van, Margolles, A., Reyes-Gavilan, C.G., de los, Stroman, P., Stuer-Lauridsen, B.   +6 more
core   +3 more sources