Differential Effects of TRPA and TRPV Channels on Behaviors of [PDF]
Journal of Experimental Neuroscience, 2016 TRPA and TRPV ion channels are members of the transient receptor potential (TRP) cation channel superfamily, which mediates various sensory transductions.
Jennifer Thies +3 more
doaj +6 more sources
The ankyrin repeat domain of the TRPA protein painless is important for thermal nociception but not mechanical nociception. [PDF]
PLoS ONE, 2012 The Drosophila TRPA channel Painless is required for the function of polymodal nociceptors which detect noxious heat and noxious mechanical stimuli. These functions of Painless are reminiscent of mammalian TRPA channels that have also been implicated in ...
Richard Y Hwang +2 more
doaj +5 more sources
Audit of the Tasmanian Transport-Related Physical Activity Policy Environment-Lessons for Comprehensive Policy Making. [PDF]
Health Promot J AustrABSTRACT Issue Addressed Government policy largely determines the transport‐related physical activity (TRPA) environment—an environment central to global PA promotion frameworks (e.g., Global Action Plan on Physical Activity). However, little is known about this policy environment—a knowledge gap this study aimed to fill in Tasmania.
Sharman MJ +4 more
europepmc +3 more sources
BMC Public Health, 2022 Introduction Transport-related physical activity (TRPA) has been identified as a way to increase physical activity due to its discretionary and habitual nature.
Jack T. Evans +4 more
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Molecular screening of prospective candidates for TRPA₁ ion channel selective antagonists [PDF]
, 2016 Using the molecular modeling techniques, we analyzed spectra of biological activity of a series of promising candidates for selective antagonists of TRPA₁ ion channel in order to find potentially active compounds against pain and ...
Kravchenko, D. V. +4 more
core +4 more sources
Response to mechanical stress is mediated by the TRPA channel painless in the Drosophila heart. [PDF]
PLoS Genetics, 2010 Mechanotransduction modulates cellular functions as diverse as migration, proliferation, differentiation, and apoptosis. It is crucial for organ development and homeostasis and leads to pathologies when defective.
Sébastien Sénatore +4 more
doaj +4 more sources
Caco-2 Intestinal Permeability Study of Phenyltetrahydroquinolinedione Derivative – TRPA₁ Antagonist
Разработка и регистрация лекарственных средств, 2022 Introduction. This work is devoted to the intestinal permeability study of 7-(2-chlorophenyl)-4-(4-methyl-1,3-thiazol-5-yl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione – innovative biologically active substance with TRPA1 antagonist activity.
N. V. Pyatigorskaya, A. D. Kravchenko
doaj +2 more sources
Correction: Response to Mechanical Stress Is Mediated by the TRPA Channel Painless in the Heart. [PDF]
PLoS Genetics, 2011 The following text replaces the corresponding text in the Materials and Methods section, which incorrectly described UAS>painlessFL constructs: "The full length painless cDNA from BDGP gold collection (RE03641) has been used as a template. In this cDNA, a TN10 transposon was found to be inserted following nucleotide 1795. To remove the TN10 transposon,
Sébastien Sénatore +4 more
doaj +5 more sources
Temperature synchronization of the Drosophila circadian clock protein PERIOD is controlled by the TRPA channel PYREXIA [PDF]
Communications Biology, 2019 AbstractCircadian clocks are endogenous molecular oscillators that temporally organize behavioral activity thereby contributing to the fitness of organisms. To synchronize the fly circadian clock with the daily fluctuations of light and temperature, these environmental cues are sensed both via brain clock neurons, and by light and temperature sensors ...
Sanne Roessingh +6 more
openaire +4 more sources
Modelling the evolution of the archaeal tryptophan synthase [PDF]
BMC Evolutionary Biology, 2007 Background Microorganisms and plants are able to produce tryptophan. Enzymes catalysing the last seven steps of tryptophan biosynthesis are encoded in the canonical trp operon.
Merkl Rainer
doaj +2 more sources