Drosophila TRPA channel painless inhibits male-male courtship behavior through modulating olfactory sensation. [PDF]
PLoS ONE, 2011 The Drosophila melanogaster TRPA family member painless, expressed in a subset of multidendritic neurons embeding in the larval epidermis, is necessary for larval nociception of noxious heat or mechanical stimuli.
Kaiyu Wang +3 more
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Characterization of TRPA channels in the starfish Patiria pectinifera: involvement of thermally activated TRPA1 in thermotaxis in marine planktonic larvae [PDF]
Scientific Reports, 2017 The vast majority of marine invertebrates spend their larval period as pelagic plankton and are exposed to various environmental cues. Here we investigated the thermotaxis behaviors of the bipinnaria larvae of the starfish, Patiria pectinifera, in ...
Shigeru Saito +7 more
doaj +3 more sources
Site-Specific Features Guiding Effective Reversible Photocontrol of Tryptophan Synthase With the Unnatural Amino Acid AzoF. [PDF]
ChembiochemReversible photocontrol of enzymes can be achieved with the azobenzene‐based photoswitchable unnatural amino acid AzoF. Screening of 85 AzoF incorporation positions in tryptophan synthase identified three features that appear to promote effective photocontrol with a success rate of up to 83%, which provides a simple guide towards the design of ...
Hiefinger C +6 more
europepmc +2 more sources
Conflicting adaptations in an inhibitory feedback circuit. [PDF]
J PhysiolAbstract figure legend We studied activity‐dependent adaptation in the fruit fly Drosophila’s memory centre, the mushroom body. Here, excitatory Kenyon cells (KCs) receive feedback inhibition from the anterior paired lateral (APL) neuron. When KCs are artificially overactivated for 24 h, both KCs and APL reduce their sensitivity to excitation (‘↓ Exc’,
Bergmann GA +5 more
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Ion channel TRPA₁ is a promising therapeutic target for treatment of pain [PDF]
, 2020 In the last time information about the role of TRPA₁ in pain and cold sensitivity, as well as in the formation and maintenance of inflammation is increasing in scientific literature.
Beskhmelnitsyna, E. A. +5 more
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mSphere, 2023 Transient receptor potential (TRP) channels are evolutionarily conserved integral membrane proteins. They serve as crucial mediators of sensory signals and have profound effects on cellular functions.
Hongchen Wang +3 more
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TRPA-1 in Planaria: Exploring Regeneration and Avoidance in the Presence of Irritants
Journal of Student Research, 2022 Planaria are a genus of freshwater flatworms widely studied for their regenerative properties. Regeneration is possible because planarians have large populations of stem cells, called neoblasts, distributed throughout their bodies. Planaria and humans share a gene that encodes for the transient receptor potential ankyrin 1 (TRPA-1), which is an ion ...
Sarah Whitney +5 more
openaire +1 more source
Molecular screening for potential selective antagonists of TRPA1 ion channel
Регуляторные исследования и экспертиза лекарственных средств, 2018 The article discusses the results of analysis a number of candidate molecules for TRPA1 ion channel selective antagonists using molecular modeling methods of high throughput screening. The study determined their mechanisms of action and specific activity
E. A. Beskhmelnitsyna +6 more
doaj +1 more source
Biology, 2022 l-Tryptophan derivatives, such as hydroxylated or halogenated l-tryptophans, are used in therapeutic peptides and agrochemicals and as precursors of bioactive compounds, such as serotonin.
Lenny Ferrer +3 more
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Airway expression of Transient Receptor Potential (TRP) Vanniloid-1 and Ankyrin-1 channels is not increased in patients with Idiopathic Pulmonary Fibrosis. [PDF]
PLoS ONE, 2017 Dry cough is a common symptom described in patients with Idiopathic Pulmonary Fibrosis (IPF) and impairs quality of life. The exact mechanisms causing cough in IPF remain unclear, however evidence suggests altered cough neurophysiology and sensitisation ...
Nicola-Xan Hutchinson +3 more
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