Results 11 to 20 of about 3,392 (133)

Nanoparticles-Mediated Modulation of TRP Channels: Advances and Therapeutic Potential. [PDF]

Wiley Interdiscip Rev Nanomed Nanobiotechnol
Nanoparticle‐mediated modulation of TRP channels, highlighting the interplay between external stimuli, tailored nanomaterials, and TRP channel activation across a range of physiological contexts. This review examines the roles of TRP channels in cellular signaling and disease, providing insights into how advances in nanotechnology can facilitate ...
Foster KA, Midler N, Shine O, Rosenfeld D.   +3 more
europepmc   +2 more sources

Defining the polycystin pharmacophore through high-throughput screening and computational biophysics. [PDF]

Br J Pharmacol
An unbiased high throughput electrophysiology screen identifies potent PKD2L1 channel inhibitors with divergent chemical composition that bind to pore fenestration receptors and stabilise their inactivated state. Abstract Background and Purpose Polycystins (PKD2, PKD2L1) are voltage‐gated and Ca2+‐modulated members of the TRP family of ion channels ...
Guadarrama E, Vanoye CG, DeCaen PG.
europepmc   +2 more sources

Prognostic Stratification and Subtyping of Glioblastoma Using Transient Receptor Potential Channels. [PDF]

Hum Mutat
Background Transient receptor potential (TRP) channels regulate Ca2+ homeostasis and tumor malignant phenotypes, whereas their prognostic relevance and therapeutic implications in glioblastoma (GBM) remain poorly characterized. Methods We curated a comprehensive compendium of 522 TRP‐related genes from MSigDB, KEGG, and GeneCards.
Sun R, Zhu L, Lu Z, Wang Z, Feng S, Zhao J.   +5 more
europepmc   +2 more sources

Nonsteroidal Anti-Inflammatory Drugs as Modulators of Cation Channels: Fenamates Repurposing in Channelopathies. [PDF]

ChemMedChem
Beyond their established role as nonsteroidal anti‐inflammatory drugs (NSAIDs), fenamates (niflumic, flufenamic, mefenamic, meclofenamic, and tolfenamic acids) have recently been identified as modulators of cationic ion channels. This review highlights their differential effects on ion channel activity and explores their potential for repurposing in ...
Laghetti P, Altamura C, Dell'Atti S, Desaphy JF, Saltarella I.   +4 more
europepmc   +2 more sources

Transient Receptor Potential Channels as Key Regulators of Neuroinflammation in Neurological Disorders: Mechanistic Insights, Therapeutic Potentials, and Future Directions. [PDF]

CNS Neurosci Ther
This study elucidates the central role of transient receptor potential (TRP) channels in driving neuroinflammation across neurological disorders. Acting as critical molecular sensors on neurons and glial cells, TRP channels' activation initiates downstream pathways that promote the release of proinflammatory cytokines, a pathological mechanism in ...
Guo D, Cai M, Xian Y, Chen Y, Feng Y, Hu C, Zeng L, Shi L, Zhang S.   +8 more
europepmc   +2 more sources

“Immuno-Transient Receptor Potential Ion Channels”: The Role in Monocyte- and Macrophage-Mediated Inflammatory Responses

Frontiers in Immunology, 2018
Monocytes and macrophages play important roles in health and disease. They have a central role in protecting the host, as they clear pathogens and modulate other immune cell functions through the production of regulatory molecules.
Giorgio Santoni, Maria Beatrice Morelli, Maria Beatrice Morelli, Consuelo Amantini, Matteo Santoni, Massimo Nabissi, Oliviero Marinelli, Oliviero Marinelli, Angela Santoni, Angela Santoni   +9 more
doaj   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Voltage-gated ion channels [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher, Striessnig, Jörg   +11 more
core   +5 more sources

The role of TRP proteins in mast cells

Frontiers in Immunology, 2012
TRP proteins form cation channels that are regulated through strikingly diverse mechanisms including multiple cell surface receptors, changes in temperature, in pH and osmolarity, in cytosolic Ca2+ concentration ([Ca2+]i) and by phosphoinositides. The 28
Marc eFreichel, Julia eAlmering, Volodymyr eTsvilovskyy   +2 more
doaj   +1 more source

Contribution of calcium-conducting channels to the transport of zinc ions. [PDF]

, 2013
International audienceZinc (Zn) is a vital nutrient participating in a myriad of biological processes. The mechanisms controlling its transport through the plasma membrane are far from being completely understood.
Bouron, Alexandre, Oberwinkler, Johannes
core   +4 more sources

The Concise Guide to PHARMACOLOGY 2015/16:Voltage-gated ion channels [PDF]

, 2015
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
,, Alexander, Stephen Ph, Benson, Helen E, Catterall, William A, Davies, Jamie A, Faccenda, Elena, Kelly, Eamonn, Marrion, Neil, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +4 more sources