Results 41 to 50 of about 41,565 (180)

GATING AND PATHOGENIC MECHANISM OF POLYCYSTIN ION CHANNELS [PDF]

, 2023
Autosomal dominant polycystic kidney disease (ADPKD), one of the most common and life-threatening human genetic diseases, is caused by mutations in PKD1 or PKD2 genes.
Wang, Yan
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, Volume 19, Issue 10, Page 2905-2920, October 2025.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Identification of Intracellular and Plasma Membrane Calcium Channel Homologues in Pathogenic Parasites [PDF]

, 2011
Ca2+ channels regulate many crucial processes within cells and their abnormal activity can be damaging to cell survival, suggesting that they might represent attractive therapeutic targets in pathogenic organisms.
A Bernsel, A Dereeper, A Giamarchi, A Prasad, AB Clarkson Jr, AB Kohn, AB Kohn, AC Ivens, AC Raabe, AG McArthur, AG Tempone, AJ Wolstenholme, AL Perraud, AP Passos, AR Marks, AT Bankier, AV Yeromin, B Arnou, B Loftus, BR Fruen, C Aurrecoechea, C Montell, Colin W. Taylor, CP Palmer, CP Ponting, CS Peacock, CW Taylor, D De Stefani, D Ren, D Sarkar, David L. Prole, DB Sattelle, DL Mendonca-Silva, DM Wetzel, DP Casemore, E Brailoiu, E Peiter, EC Laurentino, EM Ladenburger, EN Chini, ET Petri, F Yoshikawa, FH Beraldo, FH Yu, G Lisk, GM Salido, GN Bentley, GN Bentley, H Lorenzi, H Philosoph, HG Morrison, I Bosanac, I Favre, I Lange, IB Ramos, J Fang, J Gafni, J Jerlstrom-Hultqvist, J Liou, J Roos, JK Foskett, JL Lovett, JM Baughman, JM Carlton, JM Carlton, JQ Reimao, JT Smyth, K Ishibashi, K Nagamune, K Nagamune, K Paul-Pletzer, KA Brayton, KC Agboh, KM Ranatunga, KT Cheng, L Heginbotham, L Tsiokas, LD Sibley, LW Scheibel, M Berriman, M Berriman, M Biel, M Chenik, M Fill, M Fischer, M Gees, M Hohenegger, M Kang, M Kolisek, M Lalle, M Mendoza, M Paidhungat, M Prakriya, M Vig, M Yamashita, MF Wiser, MJ Berridge, MJ Gardner, MJ Gardner, ML Gazarini, ML Gazarini, ML Jones, MM Kulkarni, MS Abrahamsen, N Hall, N Klauke, NM El-Sayed, O Arnaiz, O Billker, O Franzen, P Koulen, P Rohloff, P Xu, PJ Belde, PJ Calcraft, PL Alonso, PM O'Neill, R Das, R Docampo, R Docampo, R Docampo, R Sitsapesan, RM Greenberg, RM Greenberg, RP McGeary, S Feske, S Gupta, S Raha, SG Valderramos, Silvia N. Moreno, SL Cudmore, SL Zhang, SN Moreno, SN Moreno, SN Moreno, SR Chen, T Furuichi, T Furuya, T Naderer, T Nogi, TA Day, U Eckstein-Ludwig, UK Misra, V de Paulo Martins, V Denis, V Ley, WA Catterall, X Cai, X Cheng, X Serrano-Martin, XP Dong, XP Dong, Y Zhou   +152 more
core   +3 more sources

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials

Advanced Materials, Volume 37, Issue 33, August 21, 2025.
This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang, Sílvio Terra Stefanello, Victor Shahin, Yun Qian   +3 more
wiley   +1 more source

Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics [PDF]

, 2016
Novel approaches towards cancer therapy are urgently needed. One approach might be to target ion channels mediating Ca²+ entry because of the critical roles played by Ca²+ in many cell types, including cancer cells.
A Arcangeli, A Fleckenstein, A Riccio, B Kumar, B Minke, B Vannier, B Zeng, C Carson, C Sourbier, C Strubing, CE Paulsen, CX Bai, CY Kuang, D Veliceasa, David J. Beech, DD McKemy, DE Clapham, DJ Beech, E Al-Shawaf, F Antigny, F Zheng, GR Monteith, H Wei, Hannah J. Gaunt, HB Song, HN Jiang, J Abramowitz, J Li, JC Herve, JM Richter, JM Richter, KD Phelan, KN Westlund, L Birnbaumer, L Radtke, M Liao, M Miller, M Tominaga, MC Mohl, MJ Berridge, N Damann, N Prevarskaya, Naveen S. Vasudev, NS Vasudev, P Sukumar, PC Yu, PD Wes, PK Flemming, R Ratnayake, RS Bon, S Jung, S Orrenius, SE Jordt, SZ Xu, SZ Xu, SZ Xu, T Schaldecker, T Wang, TA Stewart, V Caropreso, VV Tsvilovskyy, X Ma, X Ma, X Ma, Y Akbulut, Y Majeed, YF Chen, YR Park   +67 more
core   +2 more sources

Transient Receptor Potential channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

IUPHAR/BPS Guide to Pharmacology CITE, 2019
The TRP superfamily of channels (nomenclature as agreed by NC-IUPHAR [145, 915]), whose founder member is the Drosophila Trp channel, exists in mammals as six families; TRPC, TRPM, TRPV, TRPA, TRPP and TRPML based on amino acid homologies.
Nathaniel T. Blair, I. Carvacho, D. Chaudhuri, D. Clapham, P. DeCaen, M. Delling, Julia F. Doerner, Lu Fan, K. Ha, S. Jordt, D. Julius, K. Kahle, Boyi Liu, D. McKemy, B. Nilius, E. Oancea, G. Owsianik, A. Riccio, R. Sah, S. Stotz, J. Tian, Dan Tong, Charlotte Van den Eynde, J. Vriens, Long-Jun Wu, Haoxing Xu, Lixia Yue, Xiaoli Zhang, M. Zhu   +28 more
semanticscholar   +1 more source

Molecular Mechanisms of Chronic Pain and Therapeutic Interventions

MedComm, Volume 6, Issue 8, August 2025.
We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li, Xing Li, Jieqiong Liu, Rao Sun, Yingze Ye, Hongbing Xiang, Fang Luo, Shiyong Li, Ailin Luo   +8 more
wiley   +1 more source

Ocular transient receptor potential channel function in health and disease [PDF]

, 2015
Transient receptor potential (TRP) channels sense and transduce environmental stimuli into Ca2+ transients that in turn induce responses essential for cell function and adaptation.
Mergler, Stefan, Okada, Yuka, Reinach, Peter S., Saika, Shizuya   +3 more
core   +1 more source

Transient Receptor Potential Channels as Targets for Phytochemicals

ACS Chemical Neuroscience, 2014
To date, 28 mammalian transient receptor potential (TRP) channels have been cloned and characterized. They are grouped into six subfamilies on the basis of their amino acid sequence homology: TRP Ankyrin (TRPA), TRP Canonical (TRPC), TRP Melastatin (TRPM)
L. Premkumar
semanticscholar   +1 more source