Results 41 to 50 of about 91,395 (309)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

Comparative Evaluation of Trueness of Dental Impressions Using Digital Scanners: An In vitro Study

open access: yesJournal of Pharmacy and Bioallied Sciences
Aim: This study aims to evaluate and compare the trueness of four commercially available digital scanners. Methodology: A prepared lower first molar in a typhodont model, featuring dimple markers at line angles, served as the reference.
Ch Bindhu Sree   +5 more
doaj   +1 more source

Comparative Study of the Trueness of the Inner Surface of Crowns Fabricated from Three Types of Lithium Disilicate Blocks

open access: yesApplied Sciences, 2019
This study set out to compare the three-dimensional (3D) trueness of crowns produced from three types of lithium disilicate blocks. The working model was digitized, and single crowns (maxillary left second molar) were designed using computer-aided design
Keunbada Son   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Alignment methods to improve the trueness of digital mandibular models: A clinical study

open access: yesDigital Dentistry Journal
Objective: This study aimed to investigate how different alignment strategies influence the trueness of digital mandibular model superimpositions obtained from intraoral scans at different time points.
Edgar Daniel Vargas-Quiroga   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Impact of progressive diamond bur wear on the trueness of subtractively-manufactured lithium disilicate crowns

open access: yesDigital Dentistry Journal
Objectives: The trueness of lithium disilicate restorations produced via subtractive manufacturing is essential for long-term success, which can be related to bur degradation.
Xiaoyun Liu   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Accuracy of Cone Beam Computed Tomography and Intraoral Scanners in Dental Cast Digitization

open access: yesJournal of Indian Academy of Oral Medicine and Radiology
Background: Digital acquisition of dental casts is essential for diagnosis and treatment planning; however, the accuracy of different imaging modalities requires further evaluation. Objective: To evaluate the accuracy of CBCT and IOS in digitizing dental
Mahmoud S. Badry   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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