Results 51 to 60 of about 91,395 (309)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Does Intraoral Scanning at the Subgingival Finish Line Affect the Accuracy of Interim Crowns?

Journal of Functional Biomaterials
This in vitro study evaluated the internal surface trueness and the marginal and internal fit of interim crowns fabricated from intraoral scanner (IOS; i500, MEDIT, Seoul, Republic of Korea) data, considering variations in subgingival finish line depth ...
Young-Tak Son, Keunbada Son, Ji-Min Lee, Kyu-Bok Lee   +3 more
doaj   +1 more source

Trueness of maxillomandibular relationship in 3D-printed and conventional casts

Journal of Dentistry
To compare the trueness of maxillomandibular relationship between articulated 3D-printed and conventional diagnostic casts in maximum intercuspation (MIP).Reference casts were articulated in MIP, and scanned using a Coordinate Measurement Machine (CMM, n = 1). Digital scans were made from the reference casts by using an intraoral scanner (IOS, n = 10) (
Auškalnis, L., Akulauskas, M., Osnes, C., Revilla-León, M., Gintautė, A.K., Rutkūnas, V.   +5 more
openaire   +4 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Effect of Metal Artefacts in Guided Implant Placement: A Review on the Accuracy of 3D-Printed Surgical Implant Template

Applied Sciences
Computer-assisted implant surgery (CAIS) using 3D-printed surgical templates has become a preferred approach for improving implant placement accuracy.
Chunxu Liu, In Meei Tew, Xin Guan, Xin Fang Leong, Shahida Mohd-Said   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Evaluation of Digital Imaging Accuracy Among Three Intraoral Scanners for Full-Arch Implant Rehabilitation

Diagnostics
Background/Objectives: Accurate full-arch implant impressions are essential for predictable digital prosthodontics, yet the performance of different intraoral scanners (IOSs) remains variable.
Tareq Hajaj, Ioana Veja, Cristian Zaharia, Ioana Elena Lile, Mihai Rominu, Cosmin Sinescu, Florina Titihazan, Evelyn-Beatrice Toman, Andrei Bogdan Faur, George Dumitru Constantin   +9 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Accuracy of Intraoral Scanners in Maxillary Defects with Different Model Variations

Diagnostics
Background: Advances in digital technology and intraoral scanners (IOSs) have the potential to enable accurate digital impressions for patients with maxillary defects.
Sema Murat, Burcu Batak, Özge Aydoğ, Caner Öztürk   +3 more
doaj   +1 more source