Results 61 to 70 of about 8,731 (296)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Comparative Evaluation of Trueness of Dental Impressions Using Digital Scanners: An In vitro Study

Journal of Pharmacy and Bioallied Sciences
Aim: This study aims to evaluate and compare the trueness of four commercially available digital scanners. Methodology: A prepared lower first molar in a typhodont model, featuring dimple markers at line angles, served as the reference.
Ch Bindhu Sree, Pradeep Koka, I Kavya Sri, Jisa A. Alex, K Deepa Rani, V. Bhanu Chander   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Alignment methods to improve the trueness of digital mandibular models: A clinical study

Digital Dentistry Journal
Objective: This study aimed to investigate how different alignment strategies influence the trueness of digital mandibular model superimpositions obtained from intraoral scans at different time points.
Edgar Daniel Vargas-Quiroga, Marília Bianchini Lemos Reis, Juliana Jendiroba Faraoni, Arthur Belém Novaes, Jr., Regina Guenka Palma-Dibb, Bruna S.H. Tonin   +5 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

CAD-CAM milled versus rapidly prototyped (3D-printed) complete dentures: An in vitro evaluation of trueness. [PDF]

, 2019
STATEMENT OF PROBLEM Complete dentures fabricated by computer-aided design and computer-aided manufacturing (CAD-CAM) techniques have become popular.
Schimmel, Martin, Mehl, Albert, Müller, Frauke, Kalberer, Nicole, Srinivasan, Murali   +4 more
core   +2 more sources

Does Intraoral Scanning at the Subgingival Finish Line Affect the Accuracy of Interim Crowns?

Journal of Functional Biomaterials
This in vitro study evaluated the internal surface trueness and the marginal and internal fit of interim crowns fabricated from intraoral scanner (IOS; i500, MEDIT, Seoul, Republic of Korea) data, considering variations in subgingival finish line depth ...
Young-Tak Son, Keunbada Son, Ji-Min Lee, Kyu-Bok Lee   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source