Results 61 to 70 of about 4,298 (244)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Evaluation of the effect of different core substrates on the accuracy of intraoral scanners

Clinical and Experimental Dental Research
Background The aim of this study was to determine if different types of core substrates have any effect on the trueness and precision of digital intraoral impressions. Material and Methods A customized typodont with four similar cores of natural dentine,
Maryam Khoshkhahesh, Shabnam Enteghad, Kiana Aghasadeghi, Mitra Farzin, Masumeh Taghva, Seyed Ali Mosadad   +5 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

In vivo study of intraoral scanner trueness in partial edentulism

Scientific Reports
The purpose of this study was to evaluate the trueness of complete-arch intraoral scanning of maxillary partially edentulous patients. Sixty-four patients with partially edentulous upper jaws were recruited.
Mengxin Yao, Ning Gan, Jiajun Ming, Huijuan Cheng, Ting Jiao   +4 more
doaj   +1 more source

The Evaluation of the Trueness of Dental Mastercasts Obtained through Different 3D Printing Technologies

Journal of Functional Biomaterials
In contemporary dentistry, several 3D printing techniques, including a stereolithography apparatus (SLA), digital light processing (DLP), liquid crystal display (LCD), and PolyJet 3D inkjet printing technology (PolyJet), are employed for model production.
Lucian Toma Ciocan, Vlad Gabriel Vasilescu, Mihaela Pantea, Silviu Mirel Pițuru, Marina Imre, Alexandra Ripszky Totan, Florin Octavian Froimovici   +6 more
doaj   +1 more source

Evaluating the accuracy (precision and trueness) of conventional and digital Intraoral Impression Technique.

Erbil Dental Journal, 2023
Background and Objectives: This study aims to compare and evaluate the accuracy of the conventional and digital intraoral scanner impression approaches of the maxillary edentulous arch with indirect fixed restorations.
Lana Shwan Jalal, Dara Hamarashid Saeed
doaj  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Evaluation of the effect of thermocycling on the trueness and precision of digitally fabricated complete denture bases

BMC Oral Health
Background While many denture base materials are currently available on the market, little data exists regarding their dimensional stability after exposure to the oral environment.
Ahmed Abd El-latif Zeidan, Mohamed Ahmed Helal   +1 more
doaj   +1 more source