Results 121 to 130 of about 2,546 (170)

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, EarlyView.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Population Structure and Growth Dynamics of the Invasive Blue Crab <i>Callinectes sapidus</i> in the Loukkos Estuary (Morocco). [PDF]

Biology (Basel)
Touhami F, Bazairi H.
europepmc   +1 more source

Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function

Advanced Science, EarlyView.
Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo, Nirbhik Acharya, Maxwell B. Watkins, Carlos A. Castañeda, Shahar Sukenik   +4 more
wiley   +1 more source

Optimized NCFET-based approximate multiplier for energy-aware image applications. [PDF]

Sci Rep
Srinivas MBR, Elango K.
europepmc   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Loop dynamics govern MALT1 activation revealed by integrative AlphaFold, MD, and NMR analysis. [PDF]

Sci Rep
Lesovoy D, Agback T, Roshchin K, Sandalova T, Achour A, Han X, Lomzov A, Orekhov V, Agback P.   +8 more
europepmc   +1 more source

Ultrafast Hot‐Carrier Cooling in CsPbBr3 Supercrystals via Long‐Range Electronic Coupling

Advanced Science, EarlyView.
CsPbBr3 supercrystal self‐assembly, which induces long‐range electronic coupling, enables spatial carrier delocalization that accelerates carrier‐LO phonon scattering and weakens the Auger heating. These effects enable ultrafast, excitation‐intensity‐independent hot‐carrier cooling, offering a trade‐off‐free strategy for high‐performance perovskite ...
Junhong Yu, Manoj Sharma, Yadong Han, Ke Wang, Zhenzhong Lian, Chang Cao, Lan Nguyen, Naufan Nurrosyid, Baiquan Liu, Jacek J. Jasieniak   +9 more
wiley   +1 more source

Truncated Conjugate Structure Improves Solar-Driven Hydrogen Peroxide Production Catalyzed by Benzobisthiazole-Based Conjugated Polymers. [PDF]

Adv Sci (Weinh)
Li C, Wang Q, Lin S, Xiang X, Qi K.
europepmc   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source