Results 141 to 150 of about 2,539 (170)

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Nuclear quantum effects in molecular liquids across chemical space. [PDF]

Nat Commun
Ugur BE, Webb MA.
europepmc   +1 more source

HelixSide: A Comprehensive Method for Local and Global Orientational Analysis of Proteins. [PDF]

J Chem Inf Model
Pirnes S, Hägg V, Girych M, Vattulainen I, Enkavi G.   +4 more
europepmc   +1 more source

Research on the Genetic Polymorphism and Function of <i>inlA</i> with Premature Stop Codons in <i>Listeria monocytogenes</i>. [PDF]

Foods
Liu X, Gao B, Li Z, Liang Y, Shi T, Dong Q, Chen M, Wu H, Zhang H.   +8 more
europepmc   +1 more source

Oligomerization of PER2 as a dynamic mode of regulation of the mammalian circadian clock. [PDF]

Proc Natl Acad Sci U S A
Sanyal P, Sharma D, Viswan A, Crosby P, Narayanan V, Baumgartner J, Partch CL, Sekhar A.   +7 more
europepmc   +1 more source

Atomistic Insights into the Reactive Diffusion of CO₂ in Guanidine-Based Facilitated Transport Membranes. [PDF]

J Phys Chem C Nanomater Interfaces
Zou C, Deng X, Han Y, Lin LC.
europepmc   +1 more source

FatePredictor: Cell fate decision-making prediction with an ensemble deep learning model. [PDF]

Innovation (Camb)
Shen J, Chen N, Niu B, Zhong J, Liu R.
europepmc   +1 more source

Mechanism of RACK1-dependent ZAKα activation at stalled and collided ribosomes.

Mol Cell
Vind AC, Martínez JF, Wu Z, Bugai A, Mordente K, Abis G, Chamois S, Ramalho S, Pechincha C, Ryder L, Chen Q, Rasmussen M, Shi X, He D, Svejstrup JQ, Haahr P, Gatfield D, Conte MR, Jensen TH, Blasius M, Bekker-Jensen S.   +20 more
europepmc   +1 more source