Results 131 to 140 of about 2,539 (170)

Mechanochemical mechanism underlying intercellular Ca²⁺ wave propagation and its crucial role in apoptotic cell extrusion. [PDF]

Nat Commun
Yamada S, Yasukuni R, Bessho Y, Fujita Y, Hosokawa Y, Matsui T.   +5 more
europepmc   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Truncated Conjugate Structure Improves Solar-Driven Hydrogen Peroxide Production Catalyzed by Benzobisthiazole-Based Conjugated Polymers. [PDF]

Adv Sci (Weinh)
Li C, Wang Q, Lin S, Xiang X, Qi K.
europepmc   +1 more source

Structural and Compositional Effects on the Scintillation Properties of Fast Emitting Metal‐Organic Frameworks

Advanced Science, EarlyView.
The crystalline structure, the atomic numbers of the constituent elementsand the size of MOF crystals each influence their photoluminescence and scintillation properties in distinct ways. Together, these factors provide valuable guidelines for designing systems with optimized performance and tunable timing characteristics, arising from the synergistic ...
Francesca Cova, Jacopo Perego, Biplab Joarder, Nobuhiro Yanai, Anna Vedda, Silvia Bracco, Angiolina Comotti, Angelo Monguzzi, Irene Villa   +8 more
wiley   +1 more source

Identifying the copper coordination environment between interacting neurodegenerative proteins: A new approach using pulsed EPR with ¹⁴N/¹⁵N isotopic labeling. [PDF]

J Biol Chem
Smart A, Singewald K, Hasanbasri Z, Britt RD, Millhauser GL.   +4 more
europepmc   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

The Effect of SARS-COV-2 Protein Fragments on the Dimerization of α-Synuclein. [PDF]

ACS Chem Neurosci
Coleman LM, Hansmann UHE.
europepmc   +1 more source

Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy

Advanced Science, EarlyView.
A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru, Priyanka Bhattacharyya, Mingxu You   +2 more
wiley   +1 more source

Distributed Fiber-Optic Shape Sensing with Endpoint Error Compensation: Theory and Experimental Validation. [PDF]

Sensors (Basel)
Rossi L, Falcetelli F, Gagliardo F, Lovato P, Bastianini F, Di Sante R, Bolognini G.   +6 more
europepmc   +1 more source