Results 31 to 40 of about 129,248 (267)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko +19 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier +11 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Truncated Power-Normal Distribution with Application to Non-Negative Measurements
Entropy, 2018 This paper focuses on studying a truncated positive version of the power-normal (PN) model considered in Durrans (1992). The truncation point is considered to be zero so that the resulting model is an extension of the half normal distribution.
Nabor O. Castillo +3 more
doaj +1 more source
Non-convex perturbation to evolution problems involving Moreau’s sweeping process
Annals of the West University of Timisoara: Mathematics and Computer Science, 2023 Along this paper, we study an evolution inclusion governed by the so-called sweeping process. The right side of the inclusion contains a set-valued perturbation, supposed to be the external forces exercised on the system.
Boudjerida Nouha +2 more
doaj +1 more source
Metrics, Noise Propagation Models, and Design Framework for Floating-Point Approximate Computing
IEEE Access, 2021 Approximate computing has emerged as an efficient solution for energy saving at the expense of calculation accuracy, especially for floating-point operation intensive applications, which have urgent demands for some uniform design frameworks for floating-
Yiyao Xiang +4 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Bt Toxin Modification for Enhanced Efficacy
Toxins, 2014 Insect-specific toxins derived from Bacillus thuringiensis (Bt) provide a valuable resource for pest suppression. Here we review the different strategies that have been employed to enhance toxicity against specific target species including those that ...
Benjamin R. Deist +4 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Noun complement clauses as referential modifiers
Glossa, 2017 A number of recent analyses propose that so-called noun complement clauses should be analyzed as a type of relative clause. In this paper, I present a number of complications for any analysis that equates noun complement clauses to relative clauses, and ...
Carlos de Cuba
doaj +2 more sources