Results 41 to 50 of about 129,011 (267)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Correcting for truncation bias caused by a latent truncation variable [PDF]
Journal of Econometrics, 1985 Abstract We discuss estimation of the model Y i = X i b Y + e Yi , T i = X i b T + e Ti , when data on the continuous dependent variable Y and on the independent variables X are observed iff the ‘truncation variable’ T >0 and when T is latent. This case is distinct from both (i) the‘censored sample’ case, in which
David E. Bloom, Mark R. Killingsworth
openaire +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Truncated Power-Normal Distribution with Application to Non-Negative Measurements
Entropy, 2018 This paper focuses on studying a truncated positive version of the power-normal (PN) model considered in Durrans (1992). The truncation point is considered to be zero so that the resulting model is an extension of the half normal distribution.
Nabor O. Castillo +3 more
doaj +1 more source
Non-convex perturbation to evolution problems involving Moreau’s sweeping process
Annals of the West University of Timisoara: Mathematics and Computer Science, 2023 Along this paper, we study an evolution inclusion governed by the so-called sweeping process. The right side of the inclusion contains a set-valued perturbation, supposed to be the external forces exercised on the system.
Boudjerida Nouha +2 more
doaj +1 more source
Metrics, Noise Propagation Models, and Design Framework for Floating-Point Approximate Computing
IEEE Access, 2021 Approximate computing has emerged as an efficient solution for energy saving at the expense of calculation accuracy, especially for floating-point operation intensive applications, which have urgent demands for some uniform design frameworks for floating-
Yiyao Xiang +4 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Bt Toxin Modification for Enhanced Efficacy
Toxins, 2014 Insect-specific toxins derived from Bacillus thuringiensis (Bt) provide a valuable resource for pest suppression. Here we review the different strategies that have been employed to enhance toxicity against specific target species including those that ...
Benjamin R. Deist +4 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source