Results 51 to 60 of about 179,623 (305)
Entropy, 2022 The aim of this paper consists in developing an entropy-based approach to risk assessment for actuarial models involving truncated and censored random variables by using the Tsallis entropy measure.
Vasile Preda +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Positive solutions for nonlinear parametric singular Dirichlet problems [PDF]
Bulletin of Mathematical Sciences, 2019 We consider a nonlinear parametric Dirichlet problem driven by the p-Laplace differential operator and a reaction which has the competing effects of a parametric singular term and of a Carathéodory perturbation which is (p − 1)-linear near + ∞.
Nikolaos S. Papageorgiou +2 more
doaj +1 more source
Balanced truncation model reduction of periodic systems [PDF]
, 2000 The balanced truncation approach to model reduction is considered for linear discrete-time periodic systems with time-varying dimensions. Stability of the reduced model is proved and a guaranteed additive bound is derived for the approximation error ...
Varga, Andras
core
Fatigue crack growth behaviour and life prediction for 2324-T39 and 7050-T7451 aluminium alloys under truncated load spectra [PDF]
, 2010 This paper presents a study of crack growth behaviour in aluminium alloys 2324- T39 and 7050-T7451 subjected to flight-by-flight load spectra at different low- stress truncation levels. Crack branching was observed in the higher truncation levels for the
Bao, Rui, Zhang, Xiang
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Optimal Truncation in Matching Markets [PDF]
, 2017 Since no stable matching mechanism can induce truth-telling as a dominant strategy for all participants, there is often room in matching markets for strategic misrepresentation (Roth [25]).
Coles, Peter, Shorrer, Ran
core +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Diminutives: Exceptions to Harmonic Uniformity
Catalan Journal of Linguistics, 2016 Front-back harmony in Hungarian is governed by the root of words: it disregards suffixes in most cases. That is, a back-vowelled root (B) followed by any number of neutral-vowelled suffixes (N) will take a back-vowelled suffix (B+N+N+B), but a root with ...
Péter Rebrus, Péter Szigetvári
doaj +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source