Results 71 to 80 of about 179,623 (305)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Bounded Laplace Mechanism in Differential Privacy

The Journal of Privacy and Confidentiality, 2019
The Laplace mechanism is the workhorse of differential privacy, applied to many instances where numerical data is processed. However, the Laplace mechanism can return semantically impossible values, such as negative counts, due to its infinite support ...
Naoise Holohan, Spiros Antonatos, Stefano Braghin, Pól Mac Aonghusa   +3 more
doaj   +1 more source

Time step truncation error in direct simulation Monte Carlo [PDF]

, 1999
The time step truncation error in direct simulation Monte Carlo calculations is found to be O(Δt2) for a variety of simple flows, both transient and steady state.
Garcia, Alejandro L., Wagner, W., Alejandro L. Garcia, Garcia, Alejandro, Wagner, Wolfgang, Wolfgang Wagner   +5 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

On stochastic balancing related model reduction [PDF]

, 2000
We propose a general method based on the balanced stochastic truncation (BST) approach for the model reduction of stable linear systems. The new method relies on a recent general inner-outer factorization result and extends the applicability of the BST ...
A. Varga, Varga, Andras
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Mathematical Formalization and Applications to Data with Excess of Zeros and Ones of the Unit-Proportional Hazard Inflated Models

Mathematics
In this study, we model the rate or proportion of a specific phenomenon using a set of known covariates. To fit the regression model, which explains the phenomenon within the intervals (0,1), [0,1), (0,1], or [0,1], we employ a logit link function.
Guillermo Martínez-Flórez, Roger Tovar-Falón, Héctor W. Gómez   +2 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Truncation Structures

Order
Abstract We characterize intrinsically the truncation structures on valued fields arising from embeddings into Hahn fields with truncation closed image.
openaire   +3 more sources

Quotients of dilworth truncations

Journal of Combinatorial Theory, Series B, 1990
Sufficient conditions are given for an elementary quotient of the k-th Dilworth truncation of a matroid M to be the k-th Dilworth truncation of a quotient of M. As special cases, contractions of Dilworth truncations and principal truncations by connected flats of Dilworth truncations are characterised as Dilworth truncations of certain matroids.
openaire   +1 more source