Results 91 to 100 of about 4,252,841 (287)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Brief Announcement: Asymmetric Distributed Trust [PDF]

, 2019
Quorum systems are a key abstraction in distributed fault-tolerant computing for capturing trust assumptions. They can be found at the core of many algorithms for implementing reliable broadcasts, shared memory, consensus and other problems.
Cachin, Christian
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Curtis\u27s botanical magazine. [PDF]

, 1910
v.136=ser.4:v.6 (1910) [no.8292 ...
Bentham-Moxon Trust., Bentham-Moxon Trust., Curtis, William, 1746-1799, Hooker, Joseph Dalton, 1817-1911, Hooker, William Jackson, Sir, 1785-1865, Prain, D. 1857-, Royal Botanic Gardens, Kew., Royal Horticultural Society (Great Britain), Stanley Smith Horticultural Trust, Stanley Smith Horticultural Trust., Stapf, O. (Otto) 1857-1933   +10 more
core   +3 more sources

Trust model for certificate revocation in Ad hoc networks [PDF]

, 2007
In this paper we propose a distributed trust model for certificate revocation in Adhoc networks. The proposed model allows trust to be built over time as the number of interactions between nodes increase.
Gheorghita Ghinea, Johnson, Johnson Thomas, Kui, Lalana, Pagtzis, Sudha Chinni, Zhang, Zhengming Shen, Zhu   +9 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Building Trust in the Workplace [PDF]

, 2009
{Excerpt} Dictionary.com’s first definition of trust is “reliance on the integrity, strength, ability, surety, etc., of a person or thing; confidence.” The website prompts also that it is “the obligation or responsibility imposed on a person in whom ...
Serrat, Olivier
core   +1 more source