Results 101 to 110 of about 4,252,841 (287)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Examining the Media’s Roles and Responsibilities, an Evaluation of Nigeria’s Development Toward the SDGs

ASEAN Journal of Community Engagement
This paper examines the roles and responsibilities in the country’s development toward the Sustainable Development Goals (SDGs). The media in any society is fundamentally a development partner.
Kelvin Inobemhe, Tsegyu Santas, Aminat Trust Ogbesoh   +2 more
doaj   +1 more source

Phenolic Profile and Antioxidant Activity of the Edible Tree Peony Flower and Underlying Mechanisms of Preventive Effect on H₂O₂-Induced Oxidative Damage in Caco-2 Cells

Foods, 2019
The entire phenolic profiles and antioxidant activities of different organs of the edible tree peony flowers (Fengdan Bai (FDB)) were analyzed. HPLC-quadrupole time-of-flight mass spectrometer (Q-TOF-MS/MS) analyses of individual phenolic compounds ...
Jinle Xiang, Chengbo Yang, Trust Beta, Shangxi Liu, Runqiang Yang   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tensions in stakeholder perspectives on blockchain technology in sustainable food system transformation

Frontiers in Blockchain
IntroductionBlockchain technology (BCT) has been proposed as a solution for many challenges facing global food systems, including environmental issues related to carbon, biodiversity, and other ecosystem services. Efforts to evaluate the potential of BCT
Levi Kingfisher, Thuy Tien Nguyen Thi, Sanni Lehtonen, Trust Saidi, Trust Saidi, Linda van de Burgwal, Anne Loeber   +6 more
doaj   +1 more source

The Case for the Need for Personal Financial Literacy Education in Botswana Secondary Schools

SAGE Open, 2018
Personal financial literacy (PFL) is an imperative life skill that all 21st-century students should have. Research shows that the levels of financial literacy in both developing and developed countries are very low across people of all ages.
Gosaitse E. Solomon, Trust Nhete, Burman M. Sithole   +2 more
doaj   +1 more source

Just-in-Time Memoryless Trust for Crowdsourced IoT Services

, 2020
We propose just-in-time memoryless trust for crowdsourced IoT services. We leverage the characteristics of the IoT service environment to evaluate their trustworthiness. A novel framework is devised to assess a service's trust without relying on previous
Bahutair, Mohammed, Bouguettaya, Athman, Neiat, Azadeh Ghari   +2 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

INTERROGATING THE EFFECTS OF ARMED BANDITRY ON THE SOCIO-ECONOMIC DEVELOPMENT OF NIGERIA’S NORTH-CENTRAL REGION (2015-2022)

International Studies Journal, 2023
Armed banditry has being a major security challenge confronting northern Nigeria in recent years. Attacks orchestrated by these armed bandits have continued to escalate, especially since 2015 when the Buhari administration came into power with attendant
YUSUFU Ahmed Audu, ODAUDU Alfred Idachaba, ILEVBARE Igheoise Trust   +2 more
doaj  

The medical device development landscape in South Africa: Institutions, sectors and collaboration

South African Journal of Science, 2017
A characterisation of the medical device development landscape in South Africa would be beneficial for future policy developments that encourage locally developed devices to address local healthcare needs.
Kylie de Jager, Chipo Chimhundu, Trust Saidi, Tania S. Douglas   +3 more
doaj   +1 more source