Results 121 to 130 of about 1,460,400 (313)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
, 2010 This is the daily trust newspaper, Monday, May 24, 2010: trust is a burden, vol. 24 no. 35. Jimada Akhir 10, 1431 A.H.■ Dangote makes bid for Arsenal. ■ Plane crash lands in Kano farm. ■ Councillor, others held over Fulani killings.
MEDIA trust Nigeria limited.
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Cultures of trust and trust in science
Current Opinion in PsychologyCultures of trust are characterized by norms that promote trusting behaviors and by the expectation that others will act in trustworthy ways. Trust in science is embedded within cultures, as perceptions of the trustworthiness of science, and scientists, are shaped by cultural contexts.
Catherine T. Kwantes +2 more
openaire +3 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
, 2010 This is the daily trust newspaper, Thursday, April 15, 2010: trust is a burden, vol. 24 no. 9. Rabi'u Thani 30, 1431 A.H.■ Jonathan: I have not seen Yar'adua since Nov. ■ Court allows teen to marry grandma.
MEDIA trust Nigeria limited.
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Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Andalasian International Journal of Applied Science, Engineering, and TechnologyThis experimental study, presents results of goal programming forecasting and optimising Ti6Al4V alloy components cutting conditions. During machining the optimising challenge concerns desirability of minimalising power consumption; cutting tool wear and
Nicholas Tayisepi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source