Results 131 to 140 of about 1,845,672 (246)

Preceptorship Research Project Report: Chesterfield Royal Hospital NHS foundation trust

, 2014
Nurse education in the UK has been solely university based since the mid-1990s but despite careful preparation and assessment of student nurses it has been considered necessary to provide a period of additional support for Newly Qualified Nurses (NQNs ...
Owen, Patricia, Simmons, Maxine, Whitehead, Bill, Barton, Merryn, Beddingham, Elaine, Henshaw, L.   +5 more
core  

Beyond procedural justice: Power, identity and the asymmetric architecture of public trust in security services. [PDF]

Br J Soc Psychol
Wood P.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Trust in Generative AI for Health Information Consumption and the Effect of Learned Dependency: Randomized Controlled Experimental Study. [PDF]

J Med Internet Res
Ahmed A, Leroy G, Sachdeva A, Harber P, Rains S, Youn S, Barai P.   +6 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Radical Trust: ​ Access Services and Archives Engaged in Carceral Collecting

In the Library with the Lead Pipe
Access services policies at academic archives in the United States are, in many ways, informed by carceral logics. This essay explores the ethical implications of upholding such policies for academic archives engaged in the growing realm of carceral ...
Madeleine Murphy
doaj  

Effects of AI Assistance Timing on Pharmacists' Trust in Automated Pill Recognition Technology: Within-Participants Experimental Study. [PDF]

JMIR Hum Factors
Kim JY, Rowell B, Whitaker M, Chen Q, Al Kontar R, Lester C, Yang XJ.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Building Techno-Scientific Trust in Adaptation to Sea-Level Rise in the Dutch Online Media. [PDF]

Environ Manage
Bontenbal I, Husu HM.
europepmc   +1 more source