Results 171 to 180 of about 1,868 (198)

Methylating agents as trypanocides

Journal of Medicinal Chemistry, 1990
Methylating agents, such as streptozotocin, procarbazine, N-methyl-N-nitrosourea, dimethyl sulfate, 1,2-dimethylhydrazine, and a series of 1,2-bis(sulfonyl)-1-methylhydrazines synthesized in this laboratory, were evaluated and shown to be therapeutically active against murine models of African trypanosomiasis.
P G, Penketh, K, Shyam, A A, Divo, C L, Patton, A C, Sartorelli   +4 more
openaire   +2 more sources

Metamidium: a New Trypanocidal Drug

Nature, 1958
THIS communication describes a new trypanocide, which has been found to possess considerable potentiality as a curative and as a prophylactic drug, both in laboratory experiments and in field trials carried out in Africa during the past year.
W R, WRAGG, K, WASHBOURN, K N, BROWN, J, HILL   +3 more
openaire   +2 more sources

IMOL 881, a new trypanocidal compound

Acta Tropica, 1993
A new drug molecule (IMOL 881) was synthesized and is showing interesting trypanocidal properties. The test results on animal models indicate activity against several trypanosome species, both in the veterinary and in the human medicine application fields. The species tested so far include: T. evansi, T. equiperdum, T. gambiense and T. rhodesiense. The
L, Maes, E B, Songa, R, Hamers
openaire   +2 more sources

Trypanocidal Sesquiterpenes fromLychnophora Species

Phytotherapy Research, 1996
The bioguided fractionation of the crude extracts of Lychnophora passerina (Mart. ex DC) Gardn., L. pinaster Mart. and L. trichocarpha Spreng. led to the isolation of four compounds active against the trypomastigote forms of Trypanosoma cruzi: the sesquiterpene lactones goyazensolide (1), eremantholide C (2), and lychnopholide (3) and a new ...
Alaíde B. de Oliveira, Dênia A. Saúde, Katia S. P. Perry, Dâmaris S. Duarte, Délio S. Raslan, Maria Amélia D. Boaventura, Egler Chiari   +6 more
openaire   +1 more source

TRYPANOCIDE.

The Lancet, 1921
  +4 more sources

NEW TRYPANOCIDAL SUBSTANCES

The Lancet, 1937
H. King, E.M. Lourie, Warrington Yorke
openaire   +2 more sources

Synthesis of Potential Trypanocides

1987
Abstract : This report describes the synthesis of new compounds for evaluation as antiparasitic agents. Most of the biological data pertain to activity against Trypanosoma rhodesiense but limited data pertaining to leishmania, filarius and plasmodium are also included. Biological data is included for compounds prepared in an earlier contract. The salts
openaire   +1 more source

Trypanocides

Nature, 1978
openaire   +1 more source

trypanocidal, adj.

2023
openaire   +1 more source

Trypanocidal Drugs, Animals

2016
Wolfgang Raether, Achim Harder
openaire   +1 more source