Results 1 to 10 of about 2,658 (177)

Antitrypanosomal Activity and Molecular Docking Studies of Lobetyolin From <i>Lobelia rhynchopetalum</i> Hemsl. Root Extract Against <i>Trypanosoma congolense</i> Field Isolates. [PDF]

Biomed Res Int
Currently available drugs for trypanosomiasis are few, and their use is limited by toxicity and growing resistance. This highlights the need for safer and more effective alternatives. In this study, the in vitro and in vivo antitrypanosomal activities of an 80% methanol root extract of Lobelia rhynchopetalum and its major constituent were evaluated ...
Yimer S, Tewelde E, Bisrat D, Tadesse S, Yeshak MY.   +4 more
europepmc   +2 more sources

A gene expression comparison of Trypanosoma brucei and Trypanosoma congolense in the bloodstream of the mammalian host reveals species-specific adaptations to density-dependent development [PDF]

PLoS Neglected Tropical Diseases, 2018
In the bloodstream of mammalian hosts Trypanosoma brucei undergoes well-characterised density-dependent growth control and developmental adaptation for transmission. This involves the differentiation from proliferative, morphologically 'slender' forms to
Eleanor Silvester, Alasdair Ivens, Keith R Matthews   +2 more
exaly   +2 more sources

Route of inoculation influences Trypanosoma congolense and Trypanosoma brucei brucei virulence in Swiss white mice. [PDF]

PLoS ONE, 2019
Experiments on infections caused by trypanosomes are widely performed in Swiss white mice through various inoculation routes. To better understand the effect of route of trypanosome inoculation on disease outcomes in this model, we characterised the ...
Kariuki Ndungu, Daniel Thungu, Florence Wamwiri, Paul Mireji, Geoffrey Ngae, Purity Gitonga, James Mulinge, Joanna Auma, John Thuita   +8 more
doaj   +2 more sources

Comparative chromatin analysis of Trypanosoma congolense [PDF]

Memorias do Instituto Oswaldo Cruz, 1994
The chromatin of Trypanosoma congolense was analyzed by electron microscopy. The chromatin is organized as nucleosome filaments but does not form a 30 nm fiber. There are five groups of histones, including a histone H1-like protein, which has a molecular
Wolfram Schlimme, Markus Burri, Bruno Betschart, Hermann Hecker   +3 more
doaj   +5 more sources

TLR-2 and MyD88-Dependent Activation of MAPK and STAT Proteins Regulates Proinflammatory Cytokine Response and Immunity to Experimental Trypanosoma congolense Infection [PDF]

Frontiers in Immunology, 2019
It is known that Trypanosoma congolense infection in mice is associated with increased production of proinflammatory cytokines by macrophages and monocytes.
Shiby Kuriakose, Chukwunonso Onyilagha, Rani Singh, Folayemi Olayinka-Adefemi, Ping Jia, Jude E. Uzonna   +5 more
doaj   +2 more sources

African Trypanosomiasis Research at a Crossroads: Bibliometric and Systematic Insights for the Future. [PDF]

J Parasitol Res
Aim Despite a reduction in the overall incidence and prevalence in the last two decades, trypanosomiasis continues to be a public health concern in Africa. This study was designed to comprehensively evaluate current trends in trypanosomiasis research using bibliometric approaches to uncover emerging topics and knowledge gaps, thereby guiding future ...
Ogra IO, Adaji JZ, Jonathan EU, Nwajiani BK, Usman S, Kurovsky A, Sossou K, Balogun EO.   +7 more
europepmc   +2 more sources

Equine trypanosomiasis, a systematic review: Disease management. [PDF]

Equine Vet J
Abstract Background Equine trypanosomiasis is a neglected protozoal disease. Objectives To answer the study question: In equines what are the effects of disease management of trypanosomiasis on disease severity (individual level) and disease prevalence (population level) compared to no intervention? Study Design Systematic review.
Raftery AG, Gummery L, Garcia K, Mohite D, Capewell P, Sutton D.   +5 more
europepmc   +2 more sources

Epidemiology of Bovine Trypanosomiasis in Abe Dongoro District, Western Ethiopia: A Cross-Sectional Study. [PDF]

J Parasitol Res
Background and Aims Bovine trypanosomosis is a major protozoan disease constraining cattle productivity in sub‐Saharan Africa. This cross‐sectional study is aimed at determining the prevalence and associated risk factors of bovine trypanosomosis in the Abe Dongoro district, Western Ethiopia.
Muhammed A, Wamile M, Tamasgen N, Beyene B, Gemechu M.   +4 more
europepmc   +2 more sources

Refractory hypoglycaemia in a dog infected with Trypanosoma congolense [PDF]

Parasite, 2016
A 20 kg German shepherd dog was presented to a French veterinary teaching hospital for seizures and hyperthermia. The dog had returned 1 month previously from a six-month stay in Senegal and sub-Saharan Africa.
Deschamps Jack-Yves, Desquesnes Marc, Dorso Laetitia, Ravel Sophie, Bossard Géraldine, Charbonneau Morgane, Garand Annabelle, Roux Françoise A.   +7 more
doaj   +2 more sources

Development of Cathepsin L-like Real-Time PCR Assays for the Detection of African Animal Trypanosomosis (AAT) in South Africa

Pathogens, 2022
African animal trypanosomosis (AAT), is an infectious parasitic disease of wildlife and livestock caused by multiple species and strains of Trypanosoma.
Samantha Mnkandla, Luis Neves, Ilse Vorster, Raksha Vasantrai Bhoora   +3 more
doaj   +1 more source