Results 11 to 20 of about 7,746 (218)

A gene expression comparison of Trypanosoma brucei and Trypanosoma congolense in the bloodstream of the mammalian host reveals species-specific adaptations to density-dependent development. [PDF]

PLoS Neglected Tropical Diseases, 2018
In the bloodstream of mammalian hosts Trypanosoma brucei undergoes well-characterised density-dependent growth control and developmental adaptation for transmission. This involves the differentiation from proliferative, morphologically 'slender' forms to
Eleanor Silvester, Alasdair Ivens, Keith R Matthews   +2 more
doaj   +3 more sources

Characterisation of the surface coat of Trypanosoma congolense

Nature, 1978
THE protozoan parasites Trypanosoma congolense, T. brucei and T. vivax cause extensive disease problems to livestock in Africa1. In many cases trypanosomiasis results from mixed infections due to all three species2. Immunisation has not been successful because of the ability of the parasites to evade the host immune response by changing the antigenic ...
Rovis, L., Barbet, F., Williams, R.O.
openaire   +5 more sources

Antitrypanosomal Activity and Molecular Docking Studies of Lobetyolin From <i>Lobelia rhynchopetalum</i> Hemsl. Root Extract Against <i>Trypanosoma congolense</i> Field Isolates. [PDF]

Biomed Res Int
Currently available drugs for trypanosomiasis are few, and their use is limited by toxicity and growing resistance. This highlights the need for safer and more effective alternatives. In this study, the in vitro and in vivo antitrypanosomal activities of an 80% methanol root extract of Lobelia rhynchopetalum and its major constituent were evaluated ...
Yimer S, Tewelde E, Bisrat D, Tadesse S, Yeshak MY.   +4 more
europepmc   +2 more sources

Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral immune system [PDF]

, 2020
Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game animals around the world. Through co-evolution with the mammalian immune system, trypanosomes have developed defense mechanisms that allow them to thrive in blood,
Magez, Stefan, Obishakin, Emmanuel Tumininu, Pinto Torres, Joar Esteban, Radwanska, Magdalena   +3 more
core   +1 more source

Tsetse Flies Infected with Trypanosomes in Three Active Human African Trypanosomiasis Foci of the Republic of Congo

Pathogens, 2022
Introduction: Human African trypanosomiasis (HAT) is a neglected tropical disease still endemic in the Republic of Congo. Despite the continuous detection of HAT cases in the country, there is still not enough data on trypanosome infections in tsetse ...
Irina Bemba, Arsene Lenga, Herman Parfait Awono-Ambene, Christophe Antonio-Nkondjio   +3 more
doaj   +1 more source

Hepatocyte-derived IL-10 plays a crucial role in attenuating pathogenicity during the chronic phase of T. congolense infection [PDF]

, 2020
Bovine African Trypanosomosis is an infectious parasitic disease affecting livestock productivity and thereby impairing the economic development of Sub-Saharan Africa. The most important trypanosome species implicated is T.
Brys, Lea, De Baetselier, Patrick, De Trez, Carl, Korf, Hannelie, Magez, Stefan, Stijlemans, Benoit, Van Ginderachter, Jo A   +6 more
core   +1 more source

The Antiprotozoal Activity of Papua New Guinea Propolis and Its Triterpenes

Molecules, 2022
Profiling a propolis sample from Papua New Guinea (PNG) using high-resolution mass spectrometry indicated that it contained several triterpenoids. Further fractionation by column chromatography and medium-pressure liquid chromatography (MPLC) followed by
Samya S. Alenezi, Naif D. Alenezi, Godwin U. Ebiloma, Manal J. Natto, Marzuq A. Ungogo, John O. Igoli, Valerie A. Ferro, Alexander I. Gray, James Fearnley, Harry P. de Koning, David G. Watson   +10 more
doaj   +1 more source

Equine trypanosomiasis, a systematic review: Disease management. [PDF]

Equine Vet J
Abstract Background Equine trypanosomiasis is a neglected protozoal disease. Objectives To answer the study question: In equines what are the effects of disease management of trypanosomiasis on disease severity (individual level) and disease prevalence (population level) compared to no intervention? Study Design Systematic review.
Raftery AG, Gummery L, Garcia K, Mohite D, Capewell P, Sutton D.   +5 more
europepmc   +2 more sources

MIF-mediated hemodilution promotes pathogenic anemia in experimental African trypanosomosis [PDF]

, 2016
Animal African trypanosomosis is a major threat to the economic development and human health in sub-Saharan Africa. Trypanosoma congolense infections represent the major constraint in livestock production, with anemia as the major pathogenic lethal ...
Beschin, Alain, Bieniasz-Krzywiec, Pawel, Brys, Lea, Bucala, Richard, Caljon, Guy, De Baetselier, Patrick, De Trez, Carl, Korf, Hannelie, Leng, Lin, Magez, Stefan, Mazzone, Massimiliano, Odongo, Steven, Sparkes, Amanda, Stijlemans, Benoît, Van Den Abbeele, Jan, Van Ginderachter, Jo A, Vanbekbergen, Nele, Vansintjan, Liese   +17 more
core   +5 more sources

The individual components of commercial isometamidium do not possess stronger trypanocidal activity than the mixture, nor bypass isometamidium resistance

International Journal for Parasitology: Drugs and Drug Resistance, 2019
The four components present in the trypanocidal treatment Samorin, the commercially available formulation of isometamidium, were separated and purified by column chromatography.
Anthonius A. Eze, John Igoli, Alexander I. Gray, Graham G. Skellern, Harry P. De Koning   +4 more
doaj   +1 more source