Results 11 to 20 of about 56,922 (251)

The interaction ofTrypanosoma congolensewith endothelial cells [PDF]

Parasitology, 1994
Factors which affect adhesion of culturedTrypanosoma congolensebloodstream forms to mammalian feeder cells have been examined. Using anin vitrobinding assay, the initial events following interaction of trypanosomes with bovine aorta endothelial (BAE) cells were monitored by both light- and electron microscopy.
Hemphill A, Frame I, Ross CA
openaire   +4 more sources

Isothermal microcalorimetry – A quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Trypanosoma congolense is a protozoan parasite that is transmitted by tsetse flies, causing African Animal Trypanosomiasis, also known as Nagana, in sub-Saharan Africa. Nagana is a fatal disease of livestock that causes severe economic losses.
M. Gysin, O. Braissant, K. Gillingwater, R. Brun, P. Mäser, T. Wenzler   +5 more
doaj   +2 more sources

Proteomic Selection of Immunodiagnostic Antigens for Trypanosoma congolense [PDF]

PLoS Neglected Tropical Diseases, 2014
Animal African Trypanosomosis (AAT) presents a severe problem for agricultural development in sub-Saharan Africa. It is caused by several trypanosome species and current means of diagnosis are expensive and impractical for field use. Our aim was to discover antigens for the detection of antibodies to Trypanosoma congolense, one of the main causative ...
Fleming, Jennifer R., Sastry, Lalitha, Crozier, Thomas W. M., Napier, Grant B., Sullivan, Lauren, Ferguson, Michael A. J.   +5 more
openaire   +6 more sources

Differential virulence and tsetse fly transmissibility of Trypanosoma congolense and Trypanosoma brucei strains

Onderstepoort Journal of Veterinary Research, 2017
African animal trypanosomiasis causes significant economic losses in sub-Saharan African countries because of livestock mortalities and reduced productivity. Trypanosomes, the causative agents, are transmitted by tsetse flies (Glossina spp.).
Purity K. Gitonga, Kariuki Ndung’u, Grace A. Murilla, Paul C. Thande, Florence N. Wamwiri, Joanna E. Auma, Geoffrey N. Ngae, James K. Kibugu, Richard Kurgat, John K. Thuita   +9 more
doaj   +2 more sources

A multigene family encoding surface glycoproteins in Trypanosoma congolense [PDF]

Microbial Cell, 2017
Trypanosoma congolense, the causative agent of the most important livestock disease in Africa, expresses specific surface proteins involved in its parasitic lifestyle. Unfortunately, the complete repertoire of such molecules is far from being deciphered.
Magali Thonnus, Amandine Guéri, Loïc Rivière   +2 more
doaj   +2 more sources

Cloning and Characterization of Trypanosoma congolense and T. vivax Nucleoside Transporters Reveal the Potential of P1-Type Carriers for the Discovery of Broad-Spectrum Nucleoside-Based Therapeutics against Animal African Trypanosomiasis. [PDF]

Int J Mol Sci, 2023
African Animal Trypanosomiasis (AAT), caused predominantly by Trypanosoma brucei brucei, T. vivax and T. congolense, is a fatal livestock disease throughout Sub-Saharan Africa. Treatment options are very limited and threatened by resistance.
Ungogo MA, Aldfer MM, Natto MJ, Zhuang H, Chisholm R, Walsh K, McGee M, Ilbeigi K, Asseri JI, Burchmore RJS, Caljon G, Van Calenbergh S, De Koning HP.   +12 more
europepmc   +2 more sources

Therapeutic Efficacy of Orally Administered Nitrofurantoin against Animal African Trypanosomosis Caused by Trypanosoma congolense Infection. [PDF]

Pathogens, 2022
Animal African trypanosomosis (AAT) leads to emaciation and low productivity in infected animals. Only six drugs are commercially available against AAT; they have severe side effects and face parasite resistance.
Suganuma K, N'Da DD, Watanabe KI, Tanaka Y, Mossaad E, Elata A, Inoue N, Kawazu SI.   +7 more
europepmc   +2 more sources

Prevalence of Trypanosoma congolense and Trypanosoma vivax in Lira District, Uganda. [PDF]

Biomed Res Int, 2021
Trypanosomes are the causative agents of animal African trypanosomiasis (AAT) and human African trypanosomiasis (HAT), the former affecting domestic animals prevalent in Sub-Saharan Africa. The main species causing AAT in cattle are T.
Katabazi A, Aliero AA, Witto SG, Odoki M, Musinguzi SP.   +4 more
europepmc   +2 more sources

Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo. [PDF]

PLoS Pathog, 2021
Animal African trypanosomiasis (AAT) is a severe, wasting disease of domestic livestock and diverse wildlife species. The disease in cattle kills millions of animals each year and inflicts a major economic cost on agriculture in sub-Saharan Africa ...
Awuah-Mensah G, McDonald J, Steketee PC, Autheman D, Whipple S, D'Archivio S, Brandt C, Clare S, Harcourt K, Wright GJ, Morrison LJ, Gadelha C, Wickstead B.   +12 more
europepmc   +2 more sources

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition. [PDF]

PLoS Pathog, 2021
Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucity of
Steketee PC, Dickie EA, Iremonger J, Crouch K, Paxton E, Jayaraman S, Alfituri OA, Awuah-Mensah G, Ritchie R, Schnaufer A, Rowan T, de Koning HP, Gadelha C, Wickstead B, Barrett MP, Morrison LJ.   +15 more
europepmc   +2 more sources