Results 231 to 240 of about 41,700 (258)

Chemotherapeutic effects of Annona senegalensis in Trypanosoma brucei brucei.

Annals of Tropical Medicine and Parasitology, 1989
Mice infected with Trypanosoma brucei brucei 8/18 strain were treated orally and intramuscularly (im) with aqueous root extracts of Annona senegalensis, in doses of 27.8 mg kg-1 and 9.5 mg kg-1 respectively, for four consecutive days commencing 72 hours ...
A. Igweh, A. O. Onabanjo
semanticscholar   +1 more source

Activity of extracts and naphthoquinones from Kigelia pinnata against Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense.

Planta Medica, 1999
Dichloromethane extracts of the root bark and stem bark of Kigelia pinnata collected from Zimbabwe exhibited antitrypanosomal activity against Trypanosoma brucei brucei in vitro.
S. Moideen, Peter J. Houghton, P. Rock, S. Croft, Francis Aboagye-Nyame   +4 more
semanticscholar   +1 more source

Trypanosoma brucei and the nervous system

Trends in Neurosciences, 1994
African sleeping sickness, characterized by a peculiar pain syndrome and prominent neuropsychiatric symptoms, is caused by the parasite Trypanosoma brucei (T.b.). In experimental T.b. infections, a molecule released from the trypanosomes has been isolated that binds to the CD8 molecule of T cells, whereby T cells are activated to secrete interferon ...
Bentivoglio M., Grassi-Zucconi G., Olsson T., Kristensson K.   +3 more
openaire   +3 more sources

Effect of Trypanosoma brucei brucei on Erythropoiesis in Infected Rats

Journal of Parasitology, 2011
Anemia generated from African trypanosome infection is considered an important symptom in humans and in domestic animals. In order to recover from anemia, the process of erythropoiesis is essential. Erythropoiesis is affected by erythropoietin (EPO), an erythropoietic hormone, supplying iron and inflammatory and proinflammatory cytokines.
Hiroshi Nakagawa, Kazuhiko Nishimura, Yoshihiro Ohnishi, Haruna Nakaya, Shinji Yamasaki, Saburo Matsuo   +5 more
openaire   +3 more sources

The effect of spiroarsoranes on Trypanosoma brucei brucei and T. b. rhodesiense [PDF]

Parasitology Research, 1996
Topical application and intraperitoneal administration of spiroarsoranes were carried out to cure central nervous system (CNS) trypanosomiasis in the chronic Trypanosoma brucei GVR 35 mouse model. Topical application appeared more efficient than intraperitoneal injection. The periods of aparasitaemia after treatment were longer but none of the mice was
F.W. Jennings, P. Lubert, Philippe M. Loiseau, J. G. Wolf   +3 more
openaire   +2 more sources

Characterization of different proteolytic activities in Trypanosoma brucei brucei

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1992
The variant surface glycoprotein of African trypanosomes is released after overnight incubation of parasites at 4 degrees C in pH 5.5 phosphate glucose buffer and may be purified by Concanavalin A Sepharose affinity chromatography. The addition of proteinase inhibitors during the parasite incubation is necessary to prevent the proteolysis of the ...
Guillemente Huet, Dominique Demeyer, Daniel Tetaert, Colette Richet, Kai Ki Han, Benoit Soudan, Hervé Bisiau, Pierre Degand   +7 more
openaire   +3 more sources

Polyamine depletion following exposure to DL-alpha-difluoromethylornithine both in vivo and in vitro initiates morphological alterations and mitochondrial activation in a monomorphic strain of Trypanosoma brucei brucei.

The Journal of Protozoology, 1986
DL-alpha-difluoromethylornithine (DFMO), a specific irreversible inhibitor of ornithine decarboxylase (ODC), rapidly depletes cells of intracellular putrescine. When administered to animals and humans, DFMO cures acute infections of trypanosomiasis.
B. Giffin, P. McCann, A. Bitonti, C. Bacchi   +3 more
semanticscholar   +1 more source

Survival of Trypanosoma brucei brucei in cerebrospinal fluid

Annals of Tropical Medicine & Parasitology, 1992
Different compositions of artificial cerebrospinal fluid (CSF) and the CSF from sleeping sickness patients both with and without late-stage [i.e. central nervous system (CNS)] involvement were evaluated for their abilities to support survival of Trypanosoma brucei brucei.
V. W. Pentreath, A O Owolabi, F Doua
openaire   +2 more sources

Instability of the nuclear chromatin of procyclic Trypanosoma brucei brucei

Molecular and Biochemical Parasitology, 1989
Digestion of nuclear chromatin of Trypanosoma brucei brucei procyclic culture forms with micrococcal nuclease yielded DNA fragments which formed DNA ladders in agarose gels, similar to those of rat liver. However, the chromatin of trypanosomes was digested more rapidly. The digestion of T. b.
Klaus Bender, Bruno Betschart, Hermann Hecker, Urs-Peter Modespacher   +3 more
openaire   +3 more sources

Cysteine proteinase inhibitors kill cultured bloodstream forms of Trypanosoma brucei brucei.

Experimental parasitology, 1999
Trypanosoma brucei brucei is a causative agent of bovine trypanosomiasis (nagana), a disease of considerable economic significance in much of Africa.
L. Troeberg, R. Morty, R. Pike, J. Lonsdale-Eccles, J. Palmer, J. McKerrow, T. Coetzer   +6 more
semanticscholar   +1 more source