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cAMP signalling in Trypanosoma brucei
International Journal for Parasitology, 2001Cyclic AMP was the first second messenger to be identified. After five decades of research, much is currently known about its biological functions and clinical implications. Several components of the cAMP signalling pathways, such as the G-protein coupled receptors and the phosphodiesterases, have become sensitive and specific drug targets for a host ...
Rahel Schaub +5 more
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Chitinases in trypanosomatidae and in Trypanosoma brucei brucei: Reply
Parasitology Today, 1992In their letter to Parasitology Todaj, Arnold, Gooday and Chappell report the observation that foetal calf serum (FCS) has chitinolytic activity. They therefore assume that the chitinolytic activity recorded in our study of various trypanosomatids 2 includes the activity of the FCS that was added to the growth medium [Dulbeco's modified Eagle's medium ...
Raymond L. Jacobson, Yosef Schlein
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Infectivity reacquisition by Trypanosoma brucei brucei cultivated with tsetse salivary glands.
Science, 1977Reacquisition of infectivity four mice was observed in cultures of Trypanosoma brucei brucei grown in the presence of tests fly salivary gland explants in a medium based on the amino acid composition of Glossina hemolymph and containing fetal bovine ...
I. Cunningham, B. Honigberg
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Antioxidant defense in Trypanosoma brucei brucei
2003Two genera of protozoa belonging to the order Kinetoplastida, Trypanosoma and Leishmania, are pathogenic for mammals and cause widespread diseases of man and his livestock in developing countries. Their successful survival depends mainly on evading the hostsï immune system by penetrating and multiplying within the cells. As intracellular pathogens they
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Rodent-free cyclical transmission of Trypanosoma brucei brucei
Molecular and Biochemical Parasitology, 2017We provide a simple protocol enabling cyclical transmission of Trypanosoma brucei brucei to be performed without the need for mammals. These procedures have two advantages: they are in line with 3R principles of animal use - replace, refine, reduce - and may enable more laboratories to study the complete life cycle.
Isabel Roditi, Arunasalam Naguleswaran
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Characterization of spermidine synthase from Trypanosoma brucei brucei
Molecular and Biochemical Parasitology, 1984Spermidine synthase from Trypanosoma brucei brucei was characterized and found to be similar to spermidine synthase from other sources. The Km for putrescine was found to be 0.2 mM and the Km for decarboxylated S-adenosylmethionine 0.1 microM. The approximate molecular weight of the enzyme was 74 000 as determined by a combination of molecular sieve ...
Peter P. McCann +2 more
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Presence of a lipophosphoglycan in two variants of trypanosoma brucei brucei
Biochemical and Biophysical Research Communications, 1988For the family of Trypanosomatidae (Trypanosoma and Leishmania) the organization of the glycoproteins on the cell surface is a well documented structural feature, because their plasma membranes are potential target for chemotherapy. By using metabolic labeling ( [32P] phosphate, [3H]-myristic acid, [3H]-galactose) and by appropriate fractionated ...
Daniel Tetaert +3 more
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Protein isoprenylation in Trypanosoma brucei brucei [PDF]
Biochemical Society Transactions, 1996 Helen Field +3 more
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Pathomorphological Changes in Trypanosoma brucei brucei Infection in the Rabbit
Zentralblatt für Veterinärmedizin Reihe B, 2010Summary In the course of Trypanosoma bracei-stabilate EATRO 1066-infection in the rabbit three stages can be distinguished: 1. An initial stage at the time of the first temperature peak, characterized by beginning lymphoid hyperplasia in the follicles, lymphoid depletion in the thymus and thymus-dependent areas of the spleen and some lymph ...
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