Results 131 to 140 of about 3,726 (164)

Mechanism of Trypanosoma brucei gambiense resistance to human serum

Nature, 2013
The African parasite Trypanosoma brucei gambiense accounts for 97% of human sleeping sickness cases. T. b. gambiense resists the specific human innate immunity acting against several other tsetse-fly-transmitted trypanosome species such as T. b. brucei, the causative agent of nagana disease in cattle.
Uzureau, Pierrick, Uzureau, Sophie, Lecordier, Laurence, Fontaine, Frederic, Tebabi, Patricia, Homble, Fabrice, Grelard, Axelle, Zhendre, Vanessa, Nolan, Derek P., Lins, Laurence, Crowet, Jean-Marc, Pays, Annette, Felu, Cecile, Poelvoorde, Philippe, Vanhollebeke, Benoit, Moestrup, Soren K., Lyngso, Jeppe, Pedersen, Jan Skov, Mottram, Jeremy C., Dufourc, Erick J., Perez-Morga, David, Pays, Etienne   +21 more
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Phospholipase A₂fromTrypanosoma brucei gambienseandTrypanosoma brucei brucei: Inhibition by Organotins

Journal of Enzyme Inhibition, 2001
Activity and kinetics of phospholipase A2 (PLA2) from Trypanosoma brucei gambiense (Wellcome strain) and Trypanosoma brucei brucei (GUTat 3.1) were examined using two different fluorescent substrates. The activity in the supernatants of sonicated parasites was Ca2+-independent, strongly stimulated by Triton X-100 with optimum activity at 37 degrees C ...
M N, Shuaibu, H, Kanbara, T, Yanagi, D A, Ameh, J J, Bonire, A J, Nok   +5 more
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The role of immunoglobulins in immunity to Trypanosoma brucei gambiense

International Journal for Parasitology, 1977
Abstract The effects of IgM and IgG antibody molecules were compared on a weight basis by both agglutination and in vitro protection tests. It was shown that IgM is a better agglutinating antibody and in the presence of complement is also a better neutralizing antibody.
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Immunological control of chronic "Trypanosoma brucei gambiense" in outbred rodents

Acta tropica, 1984
Recent human isolates of Trypanosoma brucei gambiense generally fail to become or remain patent in laboratory rodents. The purpose of this study was to determine if this was due to acquired immunity and if so which immunosuppressive method was the most efficient in raising parasitemia levels.
P, Diffley, J O, Scott
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Effects of Heparin Administration on Trypanosoma brucei gambiense Infection in Rats

Journal of Parasitology, 2005
We examined whether heparin administration influences in vivo trypanosome proliferation in infected rats. Administration of heparin every 8 hr via cardiac catheter inhibited growth of Trypanosoma brucei gambiense and prolonged survival of treated rats.
Kazuhiko, Nishimura, Kensuke, Shima, Masahiro, Asakura, Yoshihiro, Ohnishi, Shinji, Yamasaki   +4 more
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Long term exposure of Trypanosoma brucei gambiense to pentamidine in vitro

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1994
In order to study the sensitivity in vitro of Trypanosoma brucei gambiense to pentamidine, 5 x 10(4) parasites were exposed to 0, 0.1, 1.0, 2.0, 10, 100, 1000 and 10,000 micrograms/L of pentamidine isethionate for up to 10 d. The viability of parasites was determined each day by microscopy.
T W, Miézan, U, Bronner, F, Doua, P, Cattand, L, Rombo   +4 more
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Freeze‐Fracture Study of the Bloodstream Form of Trypanosoma brucei gambiense

The Journal of Protozoology, 1990
ABSTRACTThe ultrastructure of Trypanosoma brucei gambiense was investigated by the freeze‐fracture method. Three different regions of the continuous plasma membrane; cell body proper, flagellar pocket, and flagellum were compared in density and distribution of the intramembranous particles (IMP's).
H, Yoshikawa, J, Furuki, Y, Takahashi, H, Morioka, Y, Yoshida   +4 more
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Efficacy and Toxicity of Eflornithine for Treatment of Trypanosoma brucei Gambiense Sleeping Sickness

Lancet, The, 1992
The usual first-line treatment for Trypanosoma brucei gambiense sleeping sickness is melarsoprol, but when that fails the outlook has hitherto been grim. The polyamine synthesis inhibitor eflornithine (difluoromethylornithine, DFMO) has emerged as an alternative therapy. 207 patients with late-stage T b gambiense sleeping sickness were treated in rural
J Pepin
exaly   +3 more sources

Neurochemical and Activity Changes in Rats Infected with Trypanosoma brucei gambiense

The Journal of Parasitology, 1984
The brains of rats infected with Trypanosoma brucei gambiense were analyzed for their content of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin, and 5-hydroxyindoleacetic acid (5-HIAA). In the caudate of infected rats, dopamine levels increased by 34% and 5-HIAA levels by 20%.
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DIFFERENTIAL EFFECTS OF INTERFERON-γ ON PRODUCTION OF TRYPANOSOME-DERIVED LYMPHOCYTE-TRIGGERING FACTOR BY TRYPANOSOMA BRUCEI GAMBIENSE AND TRYPANOSOMA BRUCEI BRUCEI

Journal of Parasitology, 2004
Trypanosome-derived lymphocyte-triggering factor (TLTF) produced by Trypanosoma brucei brucei stimulates production of interferon-gamma (IFN-gamma) by CD8+ T cells, and it is reported that, in turn, IFN-gamma stimulates proliferation of T. b. brucei. We studied the role of TLTF in trypanosome proliferation using the Wellcome strain (WS) of Trypanosoma ...
Kazuhiko, Nishimura, Kanako, Hamashita, Yasuyuki, Okamoto, Fumiya, Kawahara, Hideshi, Ihara, Shunji, Kozaki, Yoshihiro, Ohnishi, Shinji, Yamasaki   +7 more
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