Overproduction and Characterization of Recombinant Soluble Trypanosoma brucei Phospholipase A2
Engineering in Life Sciences, Volume 25, Issue 3, March 2025.ABSTRACT Trypanosoma brucei phospholipase A2 (TbPLA2) is a validated drug target but the difficulty in expressing its soluble recombinant protein has limited its exploitation for drug and vaccine development for African and American trypanosomiases. We utilized recombinant deoxyribonucleic acid (DNA) technology approaches to express soluble TbPLA2 in ...
Oluwafemi Abiodun Adepoju +9 more
wiley +1 more source
Trypanosoma congolense Infections: Induced Nitric Oxide Inhibits Parasite Growth In Vivo
Journal of Parasitology Research, 2011 Wild-type (WT) C57BL/6 mice infected intraperitoneally with 5×106 Trypanosoma congolense survive for more than 30 days. C57BL/6 mice deficient in inducible nitric oxide synthase (iNOS−/−) and infected with 103 or 5×106 parasites do not control the ...
Wenfa Lu +3 more
doaj +1 more source
Lésions génitales et histopathologie chez des cobayes mâles infectés par des trypanosomes
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1992 Les effets de Trypanosoma brucei brucei et de Trypanosoma congolense ont été étudiés sur les organes génitaux, les testicules et les capacités de reproduction de 60 cobayes adultes mâles.
B.C.O. Omeke, G.I. Onuora
doaj +1 more source
Biométrie, morphologie et virulence de Trypanosoma (Nannomonas) congolense à travers 640 passages sur souris en 10 ans [PDF]
, 1976 Trois souches de Trypanosoma congolense ont été récoltées en 1964 dans le Sud-Ouest du Sénégal et l'une d'elles passée sur souris pendant plus de 10 ans. Les trois souches présentent la variation Dimorphon.
Touré, Saydil
core
Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents
ChemMedChem, Volume 20, Issue 1, January 2, 2025.A series of isatinylhydantoin derivatives were synthesized and investigated for antileishmanial and antitrypanosomal activities in vitro and in vivo. The derivative 5 was identified with higher leishmanicidal activity than the clinical drug amphotericin B while 4b was uncovered as in vitro trypanocidal hit against T. congolense parasite.
Keamogetswe Sechoaro +5 more
wiley +1 more source
BMC Veterinary Research, 2008 Background The Gambia has an increasing population of equidae largely used for agriculture and transportation. A review of cases at The Gambian Horse and Donkey Trust (GHDT) indicated that a common reason for presentation is a poorly defined medical ...
Jallow Jibril +8 more
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Improvement of blood and fly gut processing for PCR diagnosis of trypanosomosis [PDF]
, 1996 Les auteurs ont adapté la technique de détection par PCR des trypanosomoses dans le sang humain, sans purification d'ADN, et augmenté le seuil de sensibilité à un parasite par ml. Ils l'ont ensuite appliquée à la détection de parasites dans les intestins
Cuny, Gérard +4 more
core +1 more source
Characterisation of the surface coat of Trypanosoma congolense
Nature, 1978 THE protozoan parasites Trypanosoma congolense, T. brucei and T. vivax cause extensive disease problems to livestock in Africa1. In many cases trypanosomiasis results from mixed infections due to all three species2. Immunisation has not been successful because of the ability of the parasites to evade the host immune response by changing the antigenic ...
Rovis, L., Barbet, F., Williams, R.O.
openaire +3 more sources
Sensibilité de la double microcentrifugation pour la recherche des trypanosomes [PDF]
, 1990 Les auteurs ont testé au laboratoire et sur le terrain la technique de double microcentrifugation proposée par Kratzer et Ondiek (1989) pour le diagnostic parasitologique des trypanosomoses.
Bocquentin, R. +2 more
core
Molecular characterization of Trypanosoma evansi, T. vivax and T. congolense in camels (Camelus dromedarius) of KSA [PDF]
, 2022 Jamila S. Al Malki, Nahed Ahmed Hussien
openalex +1 more source