Results 81 to 90 of about 56,922 (251)

Screening of Trypanosoma brucei gambiense in domestic livestock and tsetse flies from an insular endemic focus (Luba, Equatorial Guinea). [PDF]

, 2010
BACKGROUND: Sleeping sickness is spread over 36 Sub-Saharan African countries. In West and Central Africa, the disease is caused by Trypanosoma brucei gambiense, which produces a chronic clinical manifestation.
Abaga, Simón, Pedro Ndongo-Asumu, Ochando, Jordi, Ndong-Mabale Nicolás, Carmen García-Estébanez, Nicolás Ndong-Mabale, Ndong-Mabale, Nicolás, Agustín Benito, Carlos Cordon-Obras, Ndongo-Asumu, Pedro, Benito Agustín, García-Estébanez, Carmen, Cano, Jorge, Cordon-Obras, Carlos, Cano Jorge, Benito, Agustín, Cordon-Obras Carlos, Simón Abaga, Abaga Simón, Ndongo-Asumu Pedro, Jorge Cano, García-Estébanez Carmen   +21 more
core   +1 more source

Exploring Novel Nitrofuryl‐1,3,4‐Thiadiazole‐Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
In a series of substituted 1‐[5‐(5‐nitrofuran‐2‐yl)‐1,3,4‐thiadiazol‐2‐yl]piperidine‐4‐carboxamides evaluated for in vitro antileishmanial and antitrypanosomal activity, compound 18 emerged as the most promising derivative, showing submicromolar anti‐parasitic effects targeting diverse Leishmania and Trypanosoma species and acceptable selectivity ...
Alireza Mousavi, Martina Slapničková, Maryam Norouzbahari, Sarah D'Alessandro, Parham Foroumadi, Fariba Peytam, Federica Perego, Eva Doleželová, Zahra Emamgholipour, Maliheh Barazandeh Tehrani, Seyed Esmaeil Sadat‐Ebrahimi, Elahe Hosseinzadeh, Elmira Meghrazi Ahadi, Loghman Firoozpour, Hamidreza Bijanzadeh, Nicoletta Basilico, Alena Zíková, Alireza Foroumadi   +17 more
wiley   +1 more source

Consistent detection of Trypanosoma brucei but not T. congolense DNA in faeces of experimentally infected cattle

Scientific Reports
Animal African trypanosomiasis (AAT) is a significant food security and economic burden in sub-Saharan Africa. Current AAT empirical and immunodiagnostic surveillance tools suffer from poor sensitivity and specificity, with blood sampling requiring ...
Isabel Saldanha, Martha Betson, Christina Vrettou, Edith Paxton, James Nixon, Peter Tennant, Adrian Ritchie, Keith R. Matthews, Liam J. Morrison, Stephen J. Torr, Lucas J. Cunningham   +10 more
doaj   +1 more source

Stunning Intricacies of RNA Editing Complexes RECC, RESC, and REH2C: Functional Organization, Developmental Regulation, and Evolutionary History in Kinetoplastid Protists

WIREs RNA, Volume 17, Issue 2, March/April 2026.
U‐indel RNA editing targets mRNA:gRNA duplexes through three key complexes that collectively govern assembly, specificity, catalysis, and developmental regulation. Modern tools, including artificial intelligence, analyze the organization, dynamics, and evolution of the remarkable holo‐editosome, opening new avenues in RNA biology and therapy.
Suzanne M. McDermott, Julius Lukeš, Laurie K. Read, Reza Salavati, Achim Schnaufer, Sara L. Zimmer, Jason Carnes, Alasdair Ivens, Naghmeh Poorinmohammad, Nicholas J. Savill, Dave Speijer, Ken Stuart, Kristína Záhonová, Poorya Mirzavand Borujeni, Zihao Chen, Cody Goode, Sunil Kumar Sharma, Lars O’Hara, Jorge Cruz‐Reyes   +18 more
wiley   +1 more source

Thymic Stromal Lymphopoietin Is Critical for Regulation of Proinflammatory Cytokine Response and Resistance to Experimental Trypanosoma congolense Infection

Frontiers in Immunology, 2017
African trypanosomiasis (sleeping sickness) poses serious threat to human and animal health in sub-Saharan Africa. Because there is currently no vaccine for preventing this disease and available drugs are not safe, understanding the mechanisms that ...
Chukwunonso Onyilagha, Rani Singh, A. Gounni, J. Uzonna   +3 more
semanticscholar   +1 more source

The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications.

, 2012
The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in nature for millions of years. The human infection, named Chagas disease, is a major public health problem for Latin America. T. cruzi is genetically highly diverse and
Andrade, S. G., Sturm, N.R., Andrade, S.G., Sturm, N. R., Zingales, B., Macedo, Andrea M, Schijman, Alejandro G, Machado, C. R., Zingales, Bianca Silvana, Andrade, Sonia G, Teixeira, Marta Maria Geraldes, Zingales, Bianca, Macedo, A.M., Machado, C.R., Lages-Silva, E., Miles, M. A., Sturm, Nancy R, Miles, M.A., Schijman, A.G., Andrade, Sonia Gumes, Macedo, A. M., Teixeira, M. M. G., Tibayrenc, M., Campbell, .A., Tibayrenc, Michel, Llewellyn, M. S., Llewellyn, Martin S, Teixeira, M.M.G., Miles, Michael A, Campbell, David A, Campbell, D. A., Macedo, Andrea Mara, Teixeira, Marta MG, Schijman, A. G., Machado, Carlos Renato, Lages-Silva, Eliane, Machado, Carlos R, Llewellyn, M.S., Silva, Eliane Lages   +38 more
core   +1 more source

The flagella connector of Trypanosoma brucei : an unusual mobile transmembrane junction. [PDF]

, 2004
Throughout its elongation, the new flagellum of the procyclic form of the African trypanosome Trypanosoma brucei is tethered at its tip to the lateral aspect of the old flagellum.
Sue Vaughan, Vaughan, Sue, Vaughan, S, Davidge, J, Moreira-Leite, Flavia, Keith Gull, Baines, A, Flavia Moreira-Leite, McKean, PG, Gull, K, Moreira-Leite, F, Jacqueline Davidge, Baines, Andrea, Briggs, Laura, Gull, Keith, Laura J. Briggs, McKean, Paul G., Paul G. McKean, Davidge, Jacqueline, Briggs, LJ, Andrea Baines   +20 more
core   +1 more source

Molecular identification of trypanosome species in trypanotolerant cattle from the south of Gabon

Parasite, 2017
The aim of this study was to provide information on trypanosome species infecting trypanotolerant cattle from southern Gabon. The study was conducted on 224 trypanotolerant cattle from three regions located in southern Gabon, using ITS1 primer-based PCR.
Maganga Gaël Darren, Mavoungou Jacques-François, N’dilimabaka Nadine, Moussadji Kinga Ivan Cyr, Mvé-Ondo Bertrand, Mombo Illich Manfred, Ngoubangoye Barthélémy, Cossic Brieuc, Mikala Okouyi Clency Sylde, Souza Alain, Leroy Eric Maurice, Kumulungui Brice, Ollomo Benjamin   +12 more
doaj   +1 more source

Equine trypanosomiasis, a systematic review and meta‐analyses: Prevalence, morbidity and mortality

Equine Veterinary Journal, Volume 58, Issue 2, Page 291-319, March 2026.
Abstract Background Equine trypanosomiasis is a neglected protozoal disease. Objectives To perform a systematic search of literature to explore: (1) In equines what is the global geographical distribution and prevalence of trypanosomiasis? In low and middle‐income countries (LMICs) is trypanosomiasis more prevalent than in higher‐income countries (HICs)
Alexandra G. Raftery, Lauren Gummery, Karelhia Garcia, Dinesh Mohite, Paul Capewell, David G. M. Sutton   +5 more
wiley   +1 more source

Cytotoxicity and Antimicrobial Activity of GaMF1 Analogs

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
GaMF1 is a reported, highly potent inhibitor of mycobacterial ATP synthase. Structural modification of this scaffold significantly changes biological activity. We present GaMF1 analogues with strong antiparasitic effects, potential antiproliferative properties, and discuss the selectivity limitations of the parent compound and its analogues.
Jan Chasák, Petr Vyvlečka, Ivan Nemec, An Matheeussen, Natascha Van Pelt, Paul Cos, Guy Caljon, Vladimír Kryštof, Lucie Brulíková   +8 more
wiley   +1 more source