Results 1 to 10 of about 192 (126)
An Update on African Trypanocide Pharmaceutics and Resistance [PDF]
Frontiers in Veterinary Science, 2022 African trypanosomiasis is associated with Trypanosoma evansi, T. vivax, T. congolense, and T. brucei pathogens in African animal trypanosomiasis (AAT) while T. b gambiense and T.
Ewan Macleod +2 more
exaly +5 more sources
Tropical Medicine and Infectious Disease, 2022 Background: African trypanocide resistance is an emerging public health emergency whose control requires a revisit on farmer’s knowledge, attitudes, and practices in developing countries.
Ibrahim Ntulume +2 more
exaly +3 more sources
African animal trypanocide resistance: A systematic review and meta-analysis
Frontiers in Veterinary Science, 2023 BackgroundAfrican animal trypanocide resistance (AATr) continues to undermine global efforts to eliminate the transmission of African trypanosomiasis in endemic communities. The continued lack of new trypanocides has precipitated drug misuse and overuse,
Ewan Macleod +2 more
exaly +3 more sources
Tropical Medicine and Infectious DiseaseThe resistance of trypanosomes to the doses of trypanocide administered by farmers to their animals acts as a real brake on efforts to control to combat African trypanosomiasis.
Jagan Srinivasan +2 more
exaly +3 more sources
Trypanocide usage in the cattle belt of southwestern Uganda
Frontiers in Microbiology, 2023 BackgroundSystematic infrastructure and regulatory weaknesses over many decades, in communities struggling with animal African trypanosomiasis (AAT) would be expected to create an environment that would promote drug misuse and risk development of drug ...
Ewan Macleod +2 more
exaly +3 more sources
Piplartine Synthetic Analogs: In Silico Analysis and Antiparasitic Study against Trypanosoma cruzi
Applied Sciences, 2023 Neglected tropical diseases (NTDs) cause thousands of deaths each year. Among these diseases, we find Chagas disease, whose etiologic agent is Trypanosoma cruzi.
Rayanne H. N. Silva +5 more
doaj +1 more source
Chemosensitization of Trypanosoma congolense strains resistant to isometamidium chloride by tetracyclines and enrofloxacin. [PDF]
PLoS Neglected Tropical Diseases, 2010 BACKGROUND: Because of the development of resistance in trypanosomes to trypanocidal drugs, the livelihood of millions of livestock keepers in sub-Saharan Africa is threatened now more than ever.
Vincent Delespaux +7 more
doaj +1 more source
‘Antrycide' : A New Trypanocidal Drug [PDF]
Nature, 1949 THE discovery of a new drug, ‘Antrycide'*, showing great promise in comprehensive field trials as a trypanocide, has already been referred to in an announcement from the Colonial Office. This new drug resulted from a systematic study of the chemotherapy of trypanosomiasis in these Laboratories, and although a full account of our researches must await ...
F H S, CURD, D G, DAVEY
openaire +3 more sources
Journal of Xenobiotics, 2023 Isometamidium chloride (ISM) is a trypanocide for the prophylactic and therapeutic use against vector-borne animal trypanosomosis (mainly Surra caused by Trypanosoma evansi) and African animal trypanosomosis caused by T. congolense/T. vivax/T.
Sandeep Singh +5 more
doaj +1 more source
Systematic Review and Meta-Analysis on Human African Trypanocide Resistance
Pathogens, 2022 Background Human African trypanocide resistance (HATr) is a challenge for the eradication of Human African Trypansomiaisis (HAT) following the widespread emergence of increased monotherapy drug treatment failures against Trypanosoma brucei gambiense and ...
Keneth Iceland Kasozi +2 more
doaj +1 more source