Results 11 to 20 of about 192 (126)

Spatial–Temporal Variations in Parasitological Prevalence and Host‐Related Risk Factors of Camel Trypanosomiasis and Its Vectors in North Eastern Kenya: A Repeated Cross‐Sectional Study

Journal of Parasitology Research, Volume 2023, Issue 1, 2023., 2023
Camel trypanosomiasis (Surra) is endemic in the Horn of Africa. Understanding the spatiotemporal variations in Surra prevalence, vector dynamics, and host‐related risk factors is important in developing effective control strategies. A repeated cross‐sectional study was conducted to determine the Surra parasitological prevalence, livestock reservoirs ...
Kennedy O. Ogolla, Judith K. Chemuliti, Florence N. Wamwiri, Joanna E. Auma, Richard K. Kurgat, Kennedy B. Wanjala, Lawrence G. Mugunieri, Phylis M. Alusi, Raymond E. Mdachi, Phoebe W. Mukiria, Sylvance O. Okoth, Bernard Marchand   +11 more
wiley   +1 more source

Core‐Shell DNA‐Cholesterol Nanoparticles Exert Lysosomolytic Activity in African Trypanosomes**

ChemBioChem, Volume 23, Issue 20, October 19, 2022., 2022
The bioengineering of synthetic nanoparticles with therapeutic potential for the treatment of African sleeping sickness is reported. The molecules are DNA‐cholesterol amphiphiles, which self‐assemble into micelle‐type nanoparticles with an exterior DNA shell and a lipid core. The particles are constructed to attack two parasite‐specific targets thereby
Robert Knieß, Wolf‐Matthias Leeder, Paul Reißig, Felix Klaus Geyer, H. Ulrich Göringer   +4 more
wiley   +1 more source

Investigation on Prevalence of Canine Trypanosomiasis in the Conservation Areas of Bwindi‐Mgahinga and Queen Elizabeth in Western Uganda

Journal of Parasitology Research, Volume 2022, Issue 1, 2022., 2022
Nowadays, despite the instauration of several control strategies, animal trypanosomiasis continues to be reported all over Uganda. Few canine African trypanosomiasis (CAT) studies have been carried out, yet dogs are known Trypanosoma reservoirs that share identical home ranges with livestock and serve as parasite link between livestock and humans. This
James Robert Ochieng, Marta Planellas Bachs, Anthony Nsubuga, Innocent B. Rwego, John Joseph M. Kisakye, Laura Muro Riba, Jesus Muro Figueres, John Kagira   +7 more
wiley   +1 more source

Design, Synthesis and Biological Activity of C3 Hemisynthetic Triterpenic Esters as Novel Antitrypanosomal Hits

ChemistryOpen, Volume 10, Issue 9, Page 896-903, September 2021., 2021
A library of 12 C3 triterpenic esters was readily synthesized and tested for antiparasitic activity and cytotoxicity evaluation. C3 esterification kept the activity while lowering the cytotoxicity. The most potent antitrypanosomal activity, coupled with great selectivity, was shown by 2‐fluoro phenylpropionate, phenylpropionate and α‐methyl ...
Laura Schioppa, Claire Beaufay, Natacha Bonneau, Marianela Sanchez, Cynthia Girardi, Aurélie Leverrier, Sergio Ortiz, Jorge Palermo, Jacques H. Poupaert, Joëlle Quetin‐Leclercq   +9 more
wiley   +1 more source

Trypanocidal Activity of Flavanone Derivatives [PDF]

Molecules, 2020
Chagas disease, also known as American trypanosomiasis, is classified as a neglected disease by the World Health Organization. For clinical treatment, only two drugs have been on the market, Benznidazole and Nifurtimox, both of which are recommended for use in the acute phase but present low cure rates in the chronic phase.
Gabriela Maciel Diogo, Josimara Souza Andrade, Policarpo Ademar Sales Junior, Silvane Maria Fonseca Murta, Viviane Martins Rebello Dos Santos, Jason Guy Taylor   +5 more
openaire   +3 more sources

Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential

Molecular Microbiology, Volume 116, Issue 2, Page 564-588, August 2021., 2021
Resistance to diminazene is one of the main problems facing the control of the livestock disease Animal African Trypanosomiasis (AAT, or nagana), caused by the parasite Trypanosoma congolense. We investigated the adaptations of the parasite that allow it to resist the drug and find that changes to the mitochondrion, where the parasite produces its ...
Lauren V. Carruthers, Jane C. Munday, Godwin U. Ebiloma, Pieter Steketee, Siddharth Jayaraman, Gustavo D. Campagnaro, Marzuq A. Ungogo, Leandro Lemgruber, Anne‐Marie Donachie, Tim G. Rowan, Rose Peter, Liam J. Morrison, Michael P. Barrett, Harry P. De Koning   +13 more
wiley   +1 more source

Résistance médicamenteuse d'isolats récents de Trypanosoma brucei et Trypanosoma congolense

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1988
Des études ont été menées sur des souris pour déterminer la sensibilité aux médicaments d’isolats récents de Trypanosoma brucei et Trypanosoma congolense. Chacune des onze souches de T. congolense et des cinq souches de T. brucei, toutes isolées sur des
R.A. Joshua
doaj   +1 more source

Essai de l’efficacité du Cymelarsan™ sur Trypanosoma evansi chez le dromadaire

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1989
L’expérimentation au Niger d’une nouvelle molécule arsenicale, susceptible d’être utilisée dans le traitement de la trypanosomose cameline à Trypanosoma evansi a démontré, au cours d’un essai d’efficacité effectué sur 8 jeunes dromadaires infestés ...
Pierre Tager-Kagan, Jacques Itard, M. Clair   +2 more
doaj   +1 more source

Sensibilité aux trypanocides et au plasma humain de souches de Trypanozoon isolées d’animaux provenant de foyers endémiques de maladie du sommeil au Nigeria

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1995
La sensibilité de douze souches de Trypanozoon isolées de bovins semi-nomades provenant de foyers endémiques connus de maladie du sommeil situés dans le Centre et au Nord du Nigeria a été étudiée vis-à-vis de deux trypanocides, l'acéturate de diminazène (
A.I. Kalu
doaj   +1 more source

Prevalence of trypanosomes associated with drug resistance in Shimba Hills, Kwale County, Kenya

BMC Research Notes, 2020
Objective Animal African trypanosomiasis (AAT) is a life-threatening vector-borne disease, caused by trypanosome parasites, which are principally transmitted by tsetse flies.
Benard W. Kulohoma, Sarah A. O. Wamwenje, Ibrahim I. Wangwe, Nicodemus Masila, Caroline K. Mirieri, Lillian Wambua   +5 more
doaj   +1 more source