Results 21 to 30 of about 944 (184)
Equine trypanosomiasis, a systematic review and meta-analyses: Prevalence, morbidity and mortality. [PDF]
Equine Vet JAbstract Background Equine trypanosomiasis is a neglected protozoal disease. Objectives To perform a systematic search of literature to explore: (1) In equines what is the global geographical distribution and prevalence of trypanosomiasis? In low and middle‐income countries (LMICs) is trypanosomiasis more prevalent than in higher‐income countries (HICs)
Raftery AG +5 more
europepmc +2 more sources
Piplartine Synthetic Analogs: In Silico Analysis and Antiparasitic Study against Trypanosoma cruzi
Applied Sciences, 2023 Neglected tropical diseases (NTDs) cause thousands of deaths each year. Among these diseases, we find Chagas disease, whose etiologic agent is Trypanosoma cruzi.
Rayanne H. N. Silva +5 more
doaj +1 more source
‘Antrycide' : A New Trypanocidal Drug [PDF]
Nature, 1949 THE discovery of a new drug, ‘Antrycide'*, showing great promise in comprehensive field trials as a trypanocide, has already been referred to in an announcement from the Colonial Office. This new drug resulted from a systematic study of the chemotherapy of trypanosomiasis in these Laboratories, and although a full account of our researches must await ...
F H S, CURD, D G, DAVEY
openaire +3 more sources
Journal of Parasitology Research, Volume 2023, Issue 1, 2023., 2023 Camel trypanosomiasis (Surra) is endemic in the Horn of Africa. Understanding the spatiotemporal variations in Surra prevalence, vector dynamics, and host‐related risk factors is important in developing effective control strategies. A repeated cross‐sectional study was conducted to determine the Surra parasitological prevalence, livestock reservoirs ...
Kennedy O. Ogolla +11 more
wiley +1 more source
Core‐Shell DNA‐Cholesterol Nanoparticles Exert Lysosomolytic Activity in African Trypanosomes**
ChemBioChem, Volume 23, Issue 20, October 19, 2022., 2022 The bioengineering of synthetic nanoparticles with therapeutic potential for the treatment of African sleeping sickness is reported. The molecules are DNA‐cholesterol amphiphiles, which self‐assemble into micelle‐type nanoparticles with an exterior DNA shell and a lipid core. The particles are constructed to attack two parasite‐specific targets thereby
Robert Knieß +4 more
wiley +1 more source
Trypanocidal Activity of Flavanone Derivatives [PDF]
Molecules, 2020 Chagas disease, also known as American trypanosomiasis, is classified as a neglected disease by the World Health Organization. For clinical treatment, only two drugs have been on the market, Benznidazole and Nifurtimox, both of which are recommended for use in the acute phase but present low cure rates in the chronic phase.
Gabriela Maciel Diogo +5 more
openaire +3 more sources
Journal of Parasitology Research, Volume 2022, Issue 1, 2022., 2022 Nowadays, despite the instauration of several control strategies, animal trypanosomiasis continues to be reported all over Uganda. Few canine African trypanosomiasis (CAT) studies have been carried out, yet dogs are known Trypanosoma reservoirs that share identical home ranges with livestock and serve as parasite link between livestock and humans. This
James Robert Ochieng +7 more
wiley +1 more source
ChemistryOpen, Volume 10, Issue 9, Page 896-903, September 2021., 2021 A library of 12 C3 triterpenic esters was readily synthesized and tested for antiparasitic activity and cytotoxicity evaluation. C3 esterification kept the activity while lowering the cytotoxicity. The most potent antitrypanosomal activity, coupled with great selectivity, was shown by 2‐fluoro phenylpropionate, phenylpropionate and α‐methyl ...
Laura Schioppa +9 more
wiley +1 more source
Molecular Microbiology, Volume 116, Issue 2, Page 564-588, August 2021., 2021 Resistance to diminazene is one of the main problems facing the control of the livestock disease Animal African Trypanosomiasis (AAT, or nagana), caused by the parasite Trypanosoma congolense. We investigated the adaptations of the parasite that allow it to resist the drug and find that changes to the mitochondrion, where the parasite produces its ...
Lauren V. Carruthers +13 more
wiley +1 more source
First case report on the occurrence of Trypanosoma evansi in a Siam B Mare in Kelantan, Malaysia
Veterinary Medicine and Science, Volume 7, Issue 2, Page 303-309, March 2021., 2021 This first positive Surra case in Siam B mare in Kelantan, Malaysia, that is bordering Thailand confirms the increasing concern of transboundary infections. Thin blood smear and examination revealed the presence of Trypanosoma sp., and it was confirmed as T. evansi through molecular identification.
Nur Zul Izzati Mohd Rajdi +6 more
wiley +1 more source