Results 21 to 30 of about 1,895 (212)

Spatial–Temporal Variations in Parasitological Prevalence and Host‐Related Risk Factors of Camel Trypanosomiasis and Its Vectors in North Eastern Kenya: A Repeated Cross‐Sectional Study

Journal of Parasitology Research, Volume 2023, Issue 1, 2023., 2023
Camel trypanosomiasis (Surra) is endemic in the Horn of Africa. Understanding the spatiotemporal variations in Surra prevalence, vector dynamics, and host‐related risk factors is important in developing effective control strategies. A repeated cross‐sectional study was conducted to determine the Surra parasitological prevalence, livestock reservoirs ...
Kennedy O. Ogolla, Judith K. Chemuliti, Florence N. Wamwiri, Joanna E. Auma, Richard K. Kurgat, Kennedy B. Wanjala, Lawrence G. Mugunieri, Phylis M. Alusi, Raymond E. Mdachi, Phoebe W. Mukiria, Sylvance O. Okoth, Bernard Marchand   +11 more
wiley   +1 more source

Core‐Shell DNA‐Cholesterol Nanoparticles Exert Lysosomolytic Activity in African Trypanosomes**

ChemBioChem, Volume 23, Issue 20, October 19, 2022., 2022
The bioengineering of synthetic nanoparticles with therapeutic potential for the treatment of African sleeping sickness is reported. The molecules are DNA‐cholesterol amphiphiles, which self‐assemble into micelle‐type nanoparticles with an exterior DNA shell and a lipid core. The particles are constructed to attack two parasite‐specific targets thereby
Robert Knieß, Wolf‐Matthias Leeder, Paul Reißig, Felix Klaus Geyer, H. Ulrich Göringer   +4 more
wiley   +1 more source

Investigation on Prevalence of Canine Trypanosomiasis in the Conservation Areas of Bwindi‐Mgahinga and Queen Elizabeth in Western Uganda

Journal of Parasitology Research, Volume 2022, Issue 1, 2022., 2022
Nowadays, despite the instauration of several control strategies, animal trypanosomiasis continues to be reported all over Uganda. Few canine African trypanosomiasis (CAT) studies have been carried out, yet dogs are known Trypanosoma reservoirs that share identical home ranges with livestock and serve as parasite link between livestock and humans. This
James Robert Ochieng, Marta Planellas Bachs, Anthony Nsubuga, Innocent B. Rwego, John Joseph M. Kisakye, Laura Muro Riba, Jesus Muro Figueres, John Kagira   +7 more
wiley   +1 more source

Design, Synthesis and Biological Activity of C3 Hemisynthetic Triterpenic Esters as Novel Antitrypanosomal Hits

ChemistryOpen, Volume 10, Issue 9, Page 896-903, September 2021., 2021
A library of 12 C3 triterpenic esters was readily synthesized and tested for antiparasitic activity and cytotoxicity evaluation. C3 esterification kept the activity while lowering the cytotoxicity. The most potent antitrypanosomal activity, coupled with great selectivity, was shown by 2‐fluoro phenylpropionate, phenylpropionate and α‐methyl ...
Laura Schioppa, Claire Beaufay, Natacha Bonneau, Marianela Sanchez, Cynthia Girardi, Aurélie Leverrier, Sergio Ortiz, Jorge Palermo, Jacques H. Poupaert, Joëlle Quetin‐Leclercq   +9 more
wiley   +1 more source

Assessment of animal African trypanosomiasis (AAT) vulnerability in cattle-owning communities of sub-Saharan Africa [PDF]

, 2016
Background: Animal African trypanosomiasis (AAT) is one of the biggest constraints to livestock production and a threat to food security in sub-Saharan Africa.
A Hagos, A Mamoudou, A Mamoudou, A Mamoudou, A Miruk, A Soudré, A Sow, A Teko-Agbo, APM Shaw, C Waiswa, C. Mumba, D Grace, D Muhanguzi, EH Waaij van der, G Cecchi, G Hendrickx, G Rowlands, G. B. Napier, GA Vale, GK Fuller, H Buyst, H Simukoko, H. R. Holt, J Bouyer, J McDermott, J Woodford, J. Guitian, L Sinyangwe, M Abdoulmoumini, M Chanie, M Pinder, M Simon-Grifé, MJB Vreysen, N Machila, N Machila, NE Anderson, OD Cardona, P Bossche Van den, P Solano, PP Simarro, R Fikru, R Selby, R. Selby, S Costard, S Tasew, V Delespaux   +45 more
core   +6 more sources

Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential

Molecular Microbiology, Volume 116, Issue 2, Page 564-588, August 2021., 2021
Resistance to diminazene is one of the main problems facing the control of the livestock disease Animal African Trypanosomiasis (AAT, or nagana), caused by the parasite Trypanosoma congolense. We investigated the adaptations of the parasite that allow it to resist the drug and find that changes to the mitochondrion, where the parasite produces its ...
Lauren V. Carruthers, Jane C. Munday, Godwin U. Ebiloma, Pieter Steketee, Siddharth Jayaraman, Gustavo D. Campagnaro, Marzuq A. Ungogo, Leandro Lemgruber, Anne‐Marie Donachie, Tim G. Rowan, Rose Peter, Liam J. Morrison, Michael P. Barrett, Harry P. De Koning   +13 more
wiley   +1 more source

First case report on the occurrence of Trypanosoma evansi in a Siam B Mare in Kelantan, Malaysia

Veterinary Medicine and Science, Volume 7, Issue 2, Page 303-309, March 2021., 2021
This first positive Surra case in Siam B mare in Kelantan, Malaysia, that is bordering Thailand confirms the increasing concern of transboundary infections. Thin blood smear and examination revealed the presence of Trypanosoma sp., and it was confirmed as T. evansi through molecular identification.
Nur Zul Izzati Mohd Rajdi, Mimi Armiladiana Mohamad, Li Peng Tan, Siew Shean Choong, Mohd Farhan Hanif Reduan, Ruhil Hayati Hamdan, C. W. Salma C. W. Zalati   +6 more
wiley   +1 more source

Stress Induces Release of Extracellular Vesicles by Trypanosoma cruzi Trypomastigotes

Journal of Immunology Research, Volume 2021, Issue 1, 2021., 2021
All extracellular forms of Trypanosoma cruzi, the causative agent of Chagas disease, release extracellular vesicles (EVs) containing major surface molecules of the parasite. EV release depends on several mechanisms (internal and external). However, most of the environmental conditions affecting this phenomenon are still unknown.
Camilla Ioshida Vasconcelos, A Cronemberger-Andrade, Normanda Souza-Melo, Juliana Terzi Maricato, Patrícia Xander, Wagner Luiz Batista, Rodrigo Pedro Soares, Sergio Schenkman, Ana Claudia Torrecilhas, Ilaria Roato   +9 more
wiley   +1 more source

Antitrypanosomal Activity and Molecular Docking Studies of Lobetyolin From <i>Lobelia rhynchopetalum</i> Hemsl. Root Extract Against <i>Trypanosoma congolense</i> Field Isolates. [PDF]

Biomed Res Int
Currently available drugs for trypanosomiasis are few, and their use is limited by toxicity and growing resistance. This highlights the need for safer and more effective alternatives. In this study, the in vitro and in vivo antitrypanosomal activities of an 80% methanol root extract of Lobelia rhynchopetalum and its major constituent were evaluated ...
Yimer S, Tewelde E, Bisrat D, Tadesse S, Yeshak MY.   +4 more
europepmc   +2 more sources

Prevalence of Bovine Trypanosomosis and Its Associated Risk Factor in Hawa Galan District, Kelem Wollega Zone of Ethiopia

Veterinary Medicine International, Volume 2021, Issue 1, 2021., 2021
An analytical cross‐sectional study was performed between November 2015 and April 2016 at Hawa Galan woreda, Kelem Wollega Zone, Oromia Region, Ethiopia, to estimate the proportion of cattle with trypanosomosis and to evaluate the elements associated with the prevalence of bovine trypanosomosis.
Girma Tsegaye, Belay Abebe, Geremew Haile, Remo Lobetti   +3 more
wiley   +1 more source