Results 21 to 30 of about 640 (163)

Ascofuranone antibiotic is a promising trypanocidal drug for nagana [PDF]

Onderstepoort Journal of Veterinary Research
Trypanosomosis is a disease complex which affects both humans and animals in sub-Saharan Africa, transmitted by the tsetse fly and distributed within the tsetse belt of Africa.
Keisuke Suganuma, Kennedy M. Mochabo, Judith K. Chemuliti, Kita Kiyoshi, Inoue Noboru, Shin-ichiro Kawazu   +5 more
doaj   +2 more sources

‘Antrycide' : A New Trypanocidal Drug [PDF]

Nature, 1949
THE discovery of a new drug, ‘Antrycide'*, showing great promise in comprehensive field trials as a trypanocide, has already been referred to in an announcement from the Colonial Office. This new drug resulted from a systematic study of the chemotherapy of trypanosomiasis in these Laboratories, and although a full account of our researches must await ...
F H S, CURD, D G, DAVEY
openaire   +3 more sources

Spatial–Temporal Variations in Parasitological Prevalence and Host‐Related Risk Factors of Camel Trypanosomiasis and Its Vectors in North Eastern Kenya: A Repeated Cross‐Sectional Study

Journal of Parasitology Research, Volume 2023, Issue 1, 2023., 2023
Camel trypanosomiasis (Surra) is endemic in the Horn of Africa. Understanding the spatiotemporal variations in Surra prevalence, vector dynamics, and host‐related risk factors is important in developing effective control strategies. A repeated cross‐sectional study was conducted to determine the Surra parasitological prevalence, livestock reservoirs ...
Kennedy O. Ogolla, Judith K. Chemuliti, Florence N. Wamwiri, Joanna E. Auma, Richard K. Kurgat, Kennedy B. Wanjala, Lawrence G. Mugunieri, Phylis M. Alusi, Raymond E. Mdachi, Phoebe W. Mukiria, Sylvance O. Okoth, Bernard Marchand   +11 more
wiley   +1 more source

Core‐Shell DNA‐Cholesterol Nanoparticles Exert Lysosomolytic Activity in African Trypanosomes**

ChemBioChem, Volume 23, Issue 20, October 19, 2022., 2022
The bioengineering of synthetic nanoparticles with therapeutic potential for the treatment of African sleeping sickness is reported. The molecules are DNA‐cholesterol amphiphiles, which self‐assemble into micelle‐type nanoparticles with an exterior DNA shell and a lipid core. The particles are constructed to attack two parasite‐specific targets thereby
Robert Knieß, Wolf‐Matthias Leeder, Paul Reißig, Felix Klaus Geyer, H. Ulrich Göringer   +4 more
wiley   +1 more source

Investigation on Prevalence of Canine Trypanosomiasis in the Conservation Areas of Bwindi‐Mgahinga and Queen Elizabeth in Western Uganda

Journal of Parasitology Research, Volume 2022, Issue 1, 2022., 2022
Nowadays, despite the instauration of several control strategies, animal trypanosomiasis continues to be reported all over Uganda. Few canine African trypanosomiasis (CAT) studies have been carried out, yet dogs are known Trypanosoma reservoirs that share identical home ranges with livestock and serve as parasite link between livestock and humans. This
James Robert Ochieng, Marta Planellas Bachs, Anthony Nsubuga, Innocent B. Rwego, John Joseph M. Kisakye, Laura Muro Riba, Jesus Muro Figueres, John Kagira   +7 more
wiley   +1 more source

Design, Synthesis and Biological Activity of C3 Hemisynthetic Triterpenic Esters as Novel Antitrypanosomal Hits

ChemistryOpen, Volume 10, Issue 9, Page 896-903, September 2021., 2021
A library of 12 C3 triterpenic esters was readily synthesized and tested for antiparasitic activity and cytotoxicity evaluation. C3 esterification kept the activity while lowering the cytotoxicity. The most potent antitrypanosomal activity, coupled with great selectivity, was shown by 2‐fluoro phenylpropionate, phenylpropionate and α‐methyl ...
Laura Schioppa, Claire Beaufay, Natacha Bonneau, Marianela Sanchez, Cynthia Girardi, Aurélie Leverrier, Sergio Ortiz, Jorge Palermo, Jacques H. Poupaert, Joëlle Quetin‐Leclercq   +9 more
wiley   +1 more source

Trypanocidal Activity of Flavanone Derivatives [PDF]

Molecules, 2020
Chagas disease, also known as American trypanosomiasis, is classified as a neglected disease by the World Health Organization. For clinical treatment, only two drugs have been on the market, Benznidazole and Nifurtimox, both of which are recommended for use in the acute phase but present low cure rates in the chronic phase.
Gabriela Maciel Diogo, Josimara Souza Andrade, Policarpo Ademar Sales Junior, Silvane Maria Fonseca Murta, Viviane Martins Rebello Dos Santos, Jason Guy Taylor   +5 more
openaire   +3 more sources

Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae)

BMC Complementary Medicine and Therapies, 2021
Background Parasite persistence, exacerbated and sustained immune response, and continuous oxidative stress have been described to contribute to the development of the cardiac manifestations in Chronic Chagas Disease. Nevertheless, there are no efficient
Wendy Lorena Quintero, Erika Marcela Moreno, Sandra Milena Leal Pinto, Sandra Milena Sanabria, Elena Stashenko, Liliana Torcoroma García   +5 more
doaj   +1 more source

Action trypanocide de deux sels d'isométamidium

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1963
cf. fichier PDF de l'article.
Pierre Finelle, R. Lacotte
doaj   +1 more source

Trypanocidal Essential Oils: A Review

Molecules, 2020
Trypanosomiases are diseases caused by parasitic protozoan trypanosomes of the genus Trypanosoma. In humans, this includes Chagas disease and African trypanosomiasis. There are few therapeutic options, and there is low efficacy to clinical treatment. Therefore, the search for new drugs for the trypanosomiasis is urgent. This review describes studies of
Mayara Castro de Morais, Jucieudo Virgulino de Souza, Carlos da Silva Maia Bezerra Filho, Silvio Santana Dolabella, Damião Pergentino de Sousa   +4 more
openaire   +3 more sources