Results 61 to 70 of about 56,922 (251)

Myeloid-Derived Suppressor Cells Contribute to Susceptibility to Trypanosoma congolense Infection by Suppressing CD4+ T Cell Proliferation and IFN-γ Production

Journal of Immunology, 2018
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of bone marrow–derived myeloid cells that have immune-suppressive activities. These cells have been reported to suppress T cell immunity against tumors as well as in some parasitic ...
Chukwunonso Onyilagha, Shiby M. Kuriakose, N. Ikeogu, P. Jia, Jude E. Uzonna   +4 more
semanticscholar   +1 more source

Role for parasite genetic diversity in differential host responses to Trypanosoma brucei infection

, 2010
The postgenomic era has revolutionized approaches to defining host-pathogen interactions and the investigation of the influence of genetic variation in either protagonist upon infection outcome.
C. Michael R. Turner, Chan, Chi N, Tait, Andy, Andy Tait, Morrison, L.J., McLellan, Sarah, Turner, C Michael R, Sweeney, Lindsay, Chan, C.N., Liam J. Morrison, Annette MacLeod, Sweeney, L., Turner, C.M.R., Morrison, Liam J; id_orcid, Lindsay Sweeney, Chi N. Chan, Tait, A., Sarah McLellan, MacLeod, A., McLellan, S., MacLeod, Annette   +20 more
core   +1 more source

A major genetic locus in Trypanosoma brucei is a determinant of host pathology [PDF]

, 2009
The progression and variation of pathology during infections can be due to components from both host or pathogen, and/or the interaction between them. The influence of host genetic variation on disease pathology during infections with trypanosomes has ...
C. Michael R. Turner, Andy Tait, Tait Andy, Liam J Morrison, McLellan Sarah, C Michael R Turner, Annette MacLeod, Liam J. Morrison, Turner, C.M.R., Sweeney Lindsay, MacLeod Annette, Lindsay Sweeney, MacLeod, A., McLellan, S., MacLeod, Annette, Tait, Andy, Morrison, L.J., McLellan, Sarah, Turner, C Michael R, Sweeney, Lindsay, Morrison Liam J., Sweeney, L., Turner C. Michael R., Morrison, Liam J; id_orcid, Tait, A., Sarah McLellan   +25 more
core   +1 more source

Comparative evaluation of the attractiveness of new polyethylene screens versus West African tiny target for the control of tsetse flies

Medical and Veterinary Entomology, EarlyView.
The material has no significant difference in captures (non‐shiny cotton‐polyester screens vs. the shiny polyethylene screens), but the vertical screen attracted significantly more G. tachinoides for each type of material. Full white horizontal screen was significantly lower than the reference WATT.
Ernest Wendemanegde Salou, Geoffrey Gimonneau, Wilfrid Yoni, Issiaka Barry, Viral Shah, Marc Desquesnes   +5 more
wiley   +1 more source

Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from northwestern Uganda following melarsoprol withdrawal [PDF]

, 2009
Human African trypanosomiasis (HAT) manifests as a chronic infection caused by <i>Trypanosoma brucei gambiense</i>, or as a more acute form due to <i>T. b. rhodesiense</i>.
Barbara Nerima, Pascal Mäser, Nerima, B., Barrett, M.P., Nerima, Barbara, de Koning Harry P., Matovu, E., Kazibwe, Anne J., Anne J N Kazibwe, Kazibwe Anne J. N., Enock Matovu, Kazibwe, A.J.N., Mäser, Pascal, De Koning, H.P., Matovu Enock, Harry P de Koning, Barrett Michael P., de Koning, Harry P., Barrett, Michael P., Michael P Barrett, Mäser, P., Mäser Pascal, Matovu, Enock, Nerima Barbara   +23 more
core   +1 more source

Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor

eLife, 2016
The haptoglobin-haemoglobin receptor of the African trypanosome species, Trypanosoma brucei, is expressed when the parasite is in the bloodstream of the mammalian host, allowing it to acquire haem through the uptake of haptoglobin-haemoglobin complexes ...
Harriet Lane-Serff, Paula MacGregor, Lori Peacock, Olivia JS Macleod, Christopher Kay, Wendy Gibson, Matthew K Higgins, Mark Carrington   +7 more
doaj   +1 more source

Synthesis, Electrochemistry, In Vitro Antiprotozoal Efficacy and Mechanistic Study of Novel ‘Ferrantoin’ and Related Derivatives

Applied Organometallic Chemistry, Volume 40, Issue 7, July 2026.
1,2‐Disubstituted ferrocene analogues bearing hydantoin or rhodanine synthons were synthesised and assessed for antitrypanosomatid activity. An antileishmanial early lead, analogue 23, acting through ROS generation and hence oxidative stress, was uncovered.
Maryna Saayman, Janine Aucamp, Helena D. Janse van Rensburg, Christina Kannigadu, Rotondwa Mphephu, Andrew J. Swarts, Keisuke Suganuma, David D. N'Da   +7 more
wiley   +1 more source

Influence de l’infection à Trypanosoma congolense sur quelques constituants protéiques et inorganiques du sang chez le mouton

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1996
Cette étude avait pour objet d'évaluer les variations des concentrations plasmatiques de zinc, cuivre, calcium, magnésium, phosphate inorganique, protéines totales, albumine et globuline, de la sidérémie, ainsi que la capacité de fixation du fer chez des
E. Katunguka Rwakishaya
doaj   +1 more source

Nanobodies: A Promising Toolkit for Diagnostic Applications

SmartMat, Volume 7, Issue 3, June 2026.
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu, Abid Ali, Li Sun, Jiahao Hu, Lina Hameed, Saba Shafi, Ali Raza, Khuzin Dinislam, Wenjing Xing, Long Rong, Jie Lin, Jian Ma   +11 more
wiley   +1 more source

Variant antigen repertoires in Trypanosoma congolense populations and experimental infections can be profiled from deep sequence data using universal protein motifs

Genome Research, 2018
African trypanosomes are vector-borne hemoparasites of humans and animals. In the mammal, parasites evade the immune response through antigenic variation.
Sara Silva Pereira, Aitor Casas-Sánchez, L. Haines, M. Ogugo, Kihara Absolomon, M. Sanders, S. Kemp, Á. Acosta-Serrano, H. Noyes, M. Berriman, A. Jackson   +10 more
semanticscholar   +1 more source