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Catabolic metabolism in Trypanosoma cruzi
International Journal for Parasitology, 1980Abstract Culture, blood and intracellular forms of Trypanosoma cruzi have a high rate of endogenous oxygen uptake and probably utilize amino acids and carbohydrates as their exogenous energy sources. It is likely that triglyceride is the main energy reserve. Oxidation of carbohydrate by all forms is probably via a glycolytic sequence and a complete
G W, Rogerson, W E, Gutteridge
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1980
Publisher Summary Trypanosoma cruzi (T. cruzi), the causative agent of Chagas disease, is a digenetic trypanosomatid, which circulates in the bloodstream of the vertebrate host as trypomastigotes and has an obligatory intracellular phase in which the parasite multiplies as amastigotes, which differentiate into trypomastigotes.
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Publisher Summary Trypanosoma cruzi (T. cruzi), the causative agent of Chagas disease, is a digenetic trypanosomatid, which circulates in the bloodstream of the vertebrate host as trypomastigotes and has an obligatory intracellular phase in which the parasite multiplies as amastigotes, which differentiate into trypomastigotes.
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Intermediary metabolism of Trypanosoma cruzi
Parasitology Today, 1994In this article, Julio Urbino discusses the characteristics o f the intermediary metabolism of Trypanosoma cruzi (the causative agent of Chagas disease), which are responsible for the unusual capacity of this parasite to use carbohydrates or amino acids as carbon and energy sources without drastic changes in its catabolic enzyme levels(1-3).
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The Trypanosoma cruzi Proteome
Science, 2005To complement the sequencing of the three kinetoplastid genomes reported in this issue, we have undertaken a whole-organism, proteomic analysis of the four life-cycle stages of Trypanosoma cruzi . Peptides mapping to 2784 proteins in 1168 protein groups from the annotated T. cruzi genome were
J A, Atwood +7 more
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Purine metabolism in Trypanosoma cruzi
Molecular and Biochemical Parasitology, 1981Culture forms of Trypanosoma cruzi are incapable of synthesizing purines de novo from formate, glycine, or serine and require an exogenous purine for growth. Adenine, hypoxanthine, guanine, xanthine and their respective ribonucleosides are equal in their abilities to support growth.
R L, Berens +3 more
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Immunotherapy of Trypanosoma Cruzi Infections
Current Drug Target - Immune, Endocrine & Metabolic disorders, 2002The protozoan parasite Trypanosoma cruzi, causative agent of Chagas' disease, is transmitted to man and other mammals by triatominae insects, or 'kissing bugs'. Since its discovery in 1909, by Carlos Chagas, this parasite has been the object of several publications in the domains of immunology, cellular biology and of control gene organization ...
Chamond, Nathalie +2 more
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Fatty acids of Trypanosoma cruzi
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19821. The fatty acid pattern of total lipids from T. cruzi is different from one of its growth medium. 2. The distribution of major fatty acids in phospholipid fraction was linoleic (50.4%), oleic (25.6%), stearic (10.1%) and palmitic (6.3%) and in neutral lipid fraction oleic and linolelc (about 29% each), palmitic (18.3%) and stearic (9.8%). 3.
S L, Timm +2 more
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Signal Transduction in Trypanosoma cruzi
2011Signal transduction plays a key role in regulating important functions in both multicellular and unicellular organisms and largely controls the manner in which cells respond to stimuli. Signal transduction pathways coordinate the functions in different type of cells in animals and control the growth and differentiation in unicellular organisms ...
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