Results 71 to 80 of about 133,982 (304)

Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection

PLoS Pathogens, 2016
Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite, Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global insights into the T.
Yuan Li, Sheena Shah-Simpson, Kwame Okrah, A. Belew, Jungmin Choi, Kacey L. Caradonna, P. Padmanabhan, D. Ndegwa, M. Ramzi Temanni, H. C. Bravo, Najib M. El-Sayed, B. Burleigh, C. Clayton   +12 more
semanticscholar   +1 more source

Epidemiology and Molecular Typing of Trypanosoma cruzi in Naturally-Infected Hound Dogs and Associated Triatomine Vectors in Texas, USA

PLoS Neglected Tropical Diseases, 2017
Background Trypanosoma cruzi is the etiologic agent of Chagas disease throughout the Americas. Few population-level studies have examined the epidemiology of canine infection and strain types of T. cruzi that infect canines in the USA.
R. Curtis-Robles, K. Snowden, Brandon J. Dominguez, Lewis Dinges, S. Rodgers, G. Mays, S. Hamer   +6 more
semanticscholar   +1 more source

Endothelial Transmigration by Trypanosoma cruzi

PLoS ONE, 2013
Chagas heart disease, the leading cause of heart failure in Latin America, results from infection with the parasite Trypanosoma cruzi. Although T. cruzi disseminates intravascularly, how the parasite contends with the endothelial barrier to escape the bloodstream and infect tissues has not been described. Understanding the interaction between T.
Cheryl L. Olson, Conrad L. Epting, Bria M. Coates, David M. Engman, David P. Sullivan, Ming Y. Makanji, Nga Du, William A. Muller   +7 more
openaire   +5 more sources

The Complement System: A Prey of Trypanosoma cruzi

Frontiers in Microbiology, 2017
Trypanosoma cruzi is a protozoan parasite known to cause Chagas disease (CD), a neglected sickness that affects around 6–8 million people worldwide. Originally, CD was mainly found in Latin America but more recently, it has been spread to countries in ...
K. Lidani, Lorena Bavia, A. Ambrosio, I. D. de Messias-Reason   +3 more
semanticscholar   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

Host-Parasite Interactions in Chagas Disease: Genetically Unidentical Isolates of a Single Trypanosoma cruzi Strain Identified In Vitro via LSSP-PCR. [PDF]

PLoS ONE, 2015
The present study aims at establishing whether the diversity in pathogenesis within a genetically diverse host population infected with a single polyclonal strain of Trypanosoma cruzi is due to selection of specific subpopulations within the strain.
Nívia Carolina Nogueira-Paiva, Paula Melo de Abreu Vieira, Larissa Maris Rezende Oliveri, Kátia da Silva Fonseca, Gwenaelle Pound-Lana, Maykon Tavares de Oliveira, Marta de Lana, Vanja Maria Veloso, Alexandre Barbosa Reis, Washington Luiz Tafuri, Cláudia Martins Carneiro   +10 more
doaj   +1 more source

Hidden Markov Models for Gene Sequence Classification: Classifying the VSG genes in the Trypanosoma brucei Genome [PDF]

, 2015
The article presents an application of Hidden Markov Models (HMMs) for pattern recognition on genome sequences. We apply HMM for identifying genes encoding the Variant Surface Glycoprotein (VSG) in the genomes of Trypanosoma brucei (T. brucei) and other African trypanosomes. These are parasitic protozoa causative agents of sleeping sickness and several
arxiv   +1 more source

Contribution of microscopy for understanding the mechanism of action against trypanosomatids [PDF]

, 2018
Transmission electron microscopy (TEM) has proved to be a useful tool to study the ultrastructural alterations and the target organelles of new antitrypanosomatid drugs.
A Martinez-Palomo, A Montalvetti, A Rassi, AB Penissi, AE Eakin, AH Kolien, AJ Solari, AM Sánchez, Ana Yecê das Neves Pinto, C Brack, CF Silva Da, D Gonzalez-Pacanowska, DA Campbell, DA Johnston, DJ Hammond, DV Andrade, E Bontempi, E Lozano, E Lozano, E Lozano, EO Ogbadoiyi, ES Garcia, ES Lozano, F Dos Reis, FR Opperdoes, FR Opperdoes, FR Opperdoes, FS Laranja, H Meyer, H Meyer, J Aldunate, J Lukes, J McKerrow, J Mottram, JA Urbina, JA Urbina, JA Urbina, JA Urbina, JC Engel, JC Linder, JCP Dias, JCP Dias, JD Bergstrom, JD Maya, JF Turrens, JJ Marr, JL Avila, JL Avila, Juliano de Toledo, K Lazardi, K Miranda, K Miranda, KH Lee, L Simpson, LV Muschietti, M Meirelles, M Nieto, MC Elias, MCQB Elias, MR Ariyanayagam, MR Ariyanayagam, NM Sayed El, O Campetella, OS Giordano, OS Giordano, P Barrera, P Webster, PF Pimenta, R Docampo, S Sepúlveda-Boza, SD Brengio, SR Wilkinson, T Souto-Padron, T Souto-Padron, T Souto-Padron, T Souto-Padron, TA Shapiro, TS Tiuman, V Jimenez-Ortiz, V Sülsen, VP Sülsen, VP Sülsen, VV Costantino, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, Wanderley de Souza, WE Gutteridge   +90 more
core   +1 more source

Different Roles of Mitochondrial Calcium Uniporter Complex Subunits in Growth and Infectivity of Trypanosoma cruzi

mBio, 2017
Trypanosoma cruzi is the agent of Chagas disease, and the finding that this parasite possesses a mitochondrial calcium uniporter (TcMCU) with characteristics similar to that of mammalian mitochondria was fundamental for the discovery of the molecular ...
M. Chiurillo, N. Lander, Mayara S Bertolini, Melissa Storey, A. Vercesi, R. Docampo   +5 more
semanticscholar   +1 more source

The cell surface of Trypanosoma cruzi [PDF]

Memórias do Instituto Oswaldo Cruz, 1984
The cell surface of trypanosomatids is formed by the plasma membrane and a layer of sub-pellicular microtubules which are connected to the plasma membrane. The plasma membrane is composed by proteins, lipids and carbohydrates which form the glycocalix.
Souza, Wanderley de, Souto-Padrón, Thais   +1 more
openaire   +4 more sources