Results 21 to 30 of about 50,851 (204)

Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis

Acta Crystallographica Section D, Volume 79, Issue 6, Page 518-530, June 2023., 2023
Biochemical and structural analyses of cysteine synthase, the key enzyme in cysteine biosynthesis, from the protozoan pathogens Trypanosoma cruzi, T. theileri and Leishmania infantum are presented. This enzyme is a potential drug target for neglected tropical diseases such as Chagas disease and leishmaniasis.Chagas disease is a neglected tropical ...
Kate Sowerby, Stefanie Freitag-Pohl, Ana Milena Murillo, Ariel Mariano Silber, Ehmke Pohl   +4 more
wiley   +1 more source

Protein Profiles of Trypanosoma cruzi and Trypanosoma rangeli [PDF]

Parasitología latinoamericana, 2004
Trypanosoma cruzi, is a protozoan parasite, which has a close phylogenetic relationship with Trypanosoma rangeli that is not pathogenic for the vertebrate host. Both parasites have antigenic similarity, they have different and complex total protein profiles according to their morphological and physiological stage epimastigotes or trypomastigotes ...
MEJÍA, ASTRID J, PALÁU, MARÍA TERESA, ZÚÑIGA, CLAUDIO A   +2 more
openaire   +2 more sources

Genome Assembly and Genome Annotation of Leishmania martiniquensis Isolated from a Leishmaniasis Patient in Thailand

Journal of Parasitology Research, Volume 2022, Issue 1, 2022., 2022
Leishmaniasis is a parasitic disease caused by Leishmania spp. with worldwide distribution. Autochthonous leishmaniasis has been reported to result from the infection by Leishmania martiniquensis in Thailand. This species was isolated in culture and subjected to high‐throughput whole‐genome sequencing.
Songtham Anuntakarun, Atchara Phumee, Vorthon Sawaswong, Kesmanee Praianantathavorn, Witthaya Poomipak, Rungrat Jitvaropas, Padet Siriyasatien, Sunchai Payungporn, Kwang Poo Chang   +8 more
wiley   +1 more source

Administration of artinm lectin reduces the severity of the acute phase infection with Trypanosoma cruzi

FASEB BioAdvances, Volume 3, Issue 5, Page 295-304, May 2021., 2021
Abstract The acute phase of experimental Trypanosoma cruzi infection is associated with a strong inflammatory reaction, physiological changes, amastigote nests in tissues, and hematological alterations. ArtinM, a lectin extracted from Artocarpus heterophyllus seeds, is a homotetramer exhibiting immunomodulatory properties that promotes Th1 immune ...
Camila Botelho Miguel, Thiago Aparecido da silva, Wellington Francisco Rodrigues, Patrícia Kellen Martins Oliveira‐Brito, Maria Cristina Roque‐Barreira, Javier Emílio Lazo‐Chica   +5 more
wiley   +1 more source

Revisiting the development of Trypanosoma rangeli in the vertebrate host. [PDF]

Mem Inst Oswaldo Cruz
Trypanosoma rangeli is a haemoflagellate parasite that infects triatomine bugs and mammals in South and Central America. Trypanosoma cruzi, the etiological agent of Chagas disease, has a partially overlapping geographical distribution with T. rangeli, that leads to mixed human infections and cross-reactivity in immunodiagnosis. Although T.
Santos LF, Rocha FS, Lorenzo MG, Guarneri AA.   +3 more
europepmc   +5 more sources

Characterization of tubulin genes in Trypanosoma rangeli [PDF]

Molecular and Biochemical Parasitology, 1989
Tubulin genes in Trypanosoma rangeli, the only trypanosome besides T. cruzi to infect humans in America, are organized in homogeneous, alternate alpha and beta gene tandem repeats of 3.8 kb. The basic repeat was cloned, mapped and partially sequenced.
D, Esquenazi, C M, Morel, Y M, Traub-Cseko   +2 more
openaire   +2 more sources

Extent of polymorphism and selection pressure on the Trypanosoma cruzi vaccine candidate antigen Tc24

Evolutionary Applications, Volume 13, Issue 10, Page 2663-2672, December 2020., 2020
Abstract Introduction Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major public health problem in the Americas, and existing drugs have severe limitations. In this context, a vaccine would be an attractive alternative for disease control.
Audrey Arnal, Liliana Villanueva‐Lizama, Christian Teh‐Poot, Claudia Herrera, Eric Dumonteil   +4 more
wiley   +1 more source

The Infection Rates of Trypanosomes in Squirrel Monkeys at Two Sites in the Brazilian Amazon

Memorias do Instituto Oswaldo Cruz, 1997
A study was conducted to determine the prevalence of natural infections by trypanosome species in squirrel monkeys: Saimiri sciureus (Linnaeus) and Saimiri ustus (Geoffroy) caught respectively near 2 hydroelectric plants: Balbina, in the State of ...
Mariangela Ziccardi, Ricardo Lourenço-de-Oliveira   +1 more
doaj   +1 more source

The zinc finger proteins ZC3H20 and ZC3H21 stabilise mRNAs encoding membrane proteins and mitochondrial proteins in insect‐form Trypanosoma brucei

Molecular Microbiology, Volume 113, Issue 2, Page 430-451, February 2020., 2020
African trypanosomes are parasites that can grow in the blood of mammals, as "bloodstream forms", and the digestive system of Tsetse flies as "procyclic forms". ZC3H20 and ZC3H21 are related trypanosome proteins that can bind to mRNA. They are absent in growing bloodstream forms, but present in procyclic forms.
Bin Liu, Kevin Kamanyi Marucha, Christine Clayton   +2 more
wiley   +1 more source

Trypanosoma rangeli and Trypanosoma cruzi: cross-reaction among their immunogenic components [PDF]

Memórias do Instituto Oswaldo Cruz, 1996
It has been demonstrated that immuno-modu-lating mechanisms induced by epimastigotes ofTrypanosoma rangeli, an assumed harmless hu-man parasite, may have relevance to protectionagainst Trypanosoma cruzi, the causative organ-ism of Chagas’ disease (B Basso et al. 1991 Am JTrop Med Hyg 44: 413-419).
A. Saldaña, O. E. Sousa
openaire   +4 more sources