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Experimental Vaccines against Chagas Disease: A Journey through History
Chagas disease, or American trypanosomiasis, which is caused by the protozoan parasite Trypanosoma cruzi, is primarily a vector disease endemic in 21 Latin American countries, including Mexico. Although many vector control programs have been implemented, T. cruzi has not been eradicated. The development of an anti‐T.
Olivia Rodríguez-Morales +7 more
wiley +1 more source
Rhodnius stali: new vector infected by Trypanosoma rangeli (Kinetoplastida, Trypanosomatidae)
INTRODUCTION Rhodnius stali infection by Trypanosoma rangeli is reported in this study for the first time. METHODS The triatomines were collected from the campus of the Federal University of Acre in Rio Branco, Acre, Brazil.
Gabriela Vieira de Souza Castro +6 more
doaj +1 more source
In America, there are two species of Trypanosoma that can infect humans: Trypanosoma cruzi, which is responsible for Chagas disease and Trypanosoma rangeli, which is not pathogenic. We have developed a model of vaccination in mice with T.
Vanina Marini +3 more
doaj +1 more source
Metalloproteases in Trypanosoma rangeli-infected Rhodnius prolixus [PDF]
Protease activities in the haemolymph and fat body in a bloodsucking insect, Rhodnius prolixus, infected with Trypanosoma rangeli, were investigated. After SDS-polyacrylamide gel electrophoresis containing gelatin as substrate, analysis of zymograms performed on samples of different tissues of controls and insects inoculated or orally infected with ...
Feder, D +3 more
openaire +4 more sources
Trypanosoma cruzi Infection and Host Lipid Metabolism
Trypanosoma cruzi is the causative agent of Chagas disease. Approximately 8 million people are thought to be affected worldwide. Several players in host lipid metabolism have been implicated in T. cruzi‐host interactions in recent research, including macrophages, adipocytes, low density lipoprotein (LDL), low density lipoprotein receptor (LDLR), and ...
Qianqian Miao +2 more
wiley +1 more source
Trypanosoma rangeli is non pathogenic for humans but of important medical and epidemiological interest because it shares vertebrate hosts, insect vectors, reservoirs and geographic areas with T. cruzi, the etiological agent of Chagas disease.
Paula Ximena Pavia +4 more
doaj +1 more source
Trypanosoma evansi and Trypanosoma vivax, which are the major causative agents of animal trypanosomosis in Venezuela, have shown a very high immunological cross‐reactivity. Since the production of T. vivax antigens is a limiting factor as this parasite is difficult to propagate in experimental animal models, our goal has been to identify and isolate ...
Norma P. Velásquez +4 more
wiley +1 more source
Biochemical characterization of trans-sialidase TS1 variants from Trypanosoma congolense [PDF]
Background Animal African trypanosomiasis, sleeping sickness in humans and Nagana in cattle, is a resurgent disease in Africa caused by Trypanosoma parasites.
Hendrik Koliwer-Brandl +7 more
core +1 more source
T. cruzi improves the likelihood of invading or adapting to the host through its capacity to present a large repertoire of surface molecules. The metacyclic stage‐specific surface glycoprotein GP82 has been implicated in host cell invasion. GP82 is encoded by multiple genes from the trans‐sialidase superfamily.
Paulo Roberto Ceridorio Correa +8 more
wiley +1 more source
The pathological effects of Trypanosoma rangeli on Rhodnius prolixus and R. robustus, and the relation of mortality to infection, were studied under laboratory conditions. Frequent observations revealed that when the first instar nymphs of R.
N. Añez
doaj +1 more source

