Results 151 to 160 of about 5,037 (202)

Surprising variety in energy metabolism within Trypanosomatidae

Trends in Parasitology, 2009
The metabolism of Trypanosomatidae differs significantly between distinct species and can even be completely different between various life-cycle stages of the same species. It has been proposed that differences in energy metabolism are related to differences in nutrient supply in the environments of the various trypanosomatids. However, the literature
Tielens, Aloysius G M, van Hellemond, Jaap J   +1 more
openaire   +4 more sources

Pathogen Species Identification from Metagenomes in Ancient Remains: The Challenge of Identifying Human Pathogenic Species of Trypanosomatidae via Bioinformatic Tools

Genes, 2018
Accurate species identification from ancient DNA samples is a difficult task that would shed light on the evolutionary history of pathogenic microorganisms.
Denis Sereno, Mohammad Akhoundi, Pascale Perrin   +2 more
exaly   +2 more sources

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Biology and physiology of the lower Trypanosomatidae.

Microbiological Reviews, 1980
R B McGhee
exaly   +3 more sources

mRNA processing in the Trypanosomatidae

Experientia, 1991
Members of the Trypanosomatidae, which include the African trypanosomes, the American trypanosomes and the leishmanias, cause disease in vast proportions in man and his livestock and are a major detrimental factor to the social and economic well-being of the third world.
K, Perry, N, Agabian
openaire   +2 more sources

Purine and pyrimidine metabolism in the trypanosomatidae

Molecular and Biochemical Parasitology, 1984
The pathways leading to purine and pyrimidine nucleotide production in members of the family Trypanosomatidae are discussed with special emphasis on data relating to pathogenic species published from 1974 to 1983 inclusive. Trypanosomes and leishmania in general lack a de novo purine biosynthetic pathway, but have a multiplicity of possible routes for ...
D J, Hammond, W E, Gutteridge
openaire   +2 more sources

Mini-review on CRISPR-Cas9 and its potential applications to help controlling neglected tropical diseases caused by Trypanosomatidae

Infection, Genetics and Evolution, 2018
The CRISPR-Cas system, which was originally identified as a prokaryotic defense mechanism, is increasingly being used for the functional study of genes.
Sophie Thévenon, Philippe Solano, Minet Cecile   +2 more
exaly   +2 more sources

Genetic Exchange in the Trypanosomatidae

1999
The only trypanosomatid so far proved to undergo genetic exchange is Trypanosoma brucei, for which hybrid production after co-transmission of different parental strains through the tsetse fly vector has been demonstrated experimentally. Analogous mating experiments have been attempted with other Trypanosoma and Leishmania species, so far without ...
Gibson, WC, Stevens, JR
openaire   +2 more sources

The molecular evolution of trypanosomatidae

2001
In the absence of a fossil record, theories relating to the evolution of protozoa have, for most of the twentieth century, been based on morphological and life cycle data despite their known limitations. However, recent advances in molecular methodology, notably the wide availability of accurate, automated DNA sequencing, have made it possible to ...
J R, Stevens, H A, Noyes, C J, Schofield, W, Gibson   +3 more
openaire   +2 more sources

More Differences in Energy Metabolism between Trypanosomatidae

Parasitology Today, 1999
exaly   +3 more sources

Pyrazolopyrimidine metabolism in the pathogenic trypanosomatidae

Molecular and Biochemical Parasitology, 1983
Pyrazolopyrimidines are purine analogues. These compounds are metabolized by the pathogenic hemoflagellates and other members of the family Trypanosomatidae as though they were purines. This metabolic sequence does not exist in man or other mammals. In the hemoflagellates, the pyrazolopyrimidine base, of which allopurinol is the paradigm, undergoes ...
J J, Marr, R L, Berens
openaire   +2 more sources