Results 61 to 70 of about 7,027 (175)

In Vitro Leishmanicidal Efficacy of Synthesized Arylidene Analogues of Glitazone

Drug Development Research, Volume 86, Issue 5, August 2025.
ABSTRACT Diabetes is a fast‐growing health issue in low‐ and middle‐income countries, with ~80% of diabetics living in the tropics and sub‐tropics. It is a deadly condition claiming the lives of millions of individuals annually, with no therapeutic treatment available to date. The management of diabetes is thus limited to symptomatic relief by glycemic
Janine Aucamp, Helena D. Janse van Rensburg, Simon S. Mnyakeni‐Moleele, Keisuke Suganuma, David D. N'Da   +4 more
wiley   +1 more source

Research needs for Chagas disease prevention.

, 2010
We present an overview of the two main strategies for the primary (vector control) and secondary (patient care) prevention of Chagas disease (CD). We identify major advances, knowledge gaps, and key research needs in both areas.
Abad-Franch, Fernando, Santos, Walter S, Schofield, Christopher J   +2 more
core   +1 more source

Impact of migration on the occurrence of new cases of Chagas disease in Buenos Aires city, Argentina [PDF]

, 2013
Chagas disease, also known as American Trypanosomiasis, is endemic in the Americas, especially Central and South America. Chagas disease is a zoonotic disease caused by the parasite Trypanosoma cruzi.
Altcheh, Jaime Marcelo, Ballering, Griselda, Berenstein, Ada, Biancardi, Miguel Angel, Espejo Cozzi, Andres, Freillij, Hector, Garcia Bournissen, Facundo, Hernandez, Susana, Moroni, Samanta, Moscatelli, Guillermo, Schwarcz, Marta, Siniawski, Susana, Tarlovsky, Ana   +12 more
core   +2 more sources

On the Lack of Domestic Dogs in Pre‐Columbian Lowland Amazonia and Their Deep History of Entanglements With Humans in South America

The Journal of Latin American and Caribbean Anthropology, Volume 30, Issue 2, June 2025.
ABSTRACT Data from archaeology, ethnography, and ethnohistory document entanglements of dogs among South American Indigenous societies during pre‐Columbian and colonial times. The prolific presence and uses of dogs in the Central Andes and in parts of the Paraná Basin, Patagonia, and Circum‐Caribbean regions contrast with the conspicuous lack of ...
Marcelo R. Sánchez‐Villagra, Cristiana Bertazoni, Felipe Vander Velden   +2 more
wiley   +1 more source

Insights from a comprehensive study of Trypanosoma cruzi: A new mitochondrial clade restricted to North and Central America and genetic structure of TcI in the region.

PLoS Neglected Tropical Diseases, 2021
More than 100 years since the first description of Chagas Disease and with over 29,000 new cases annually due to vector transmission (in 2010), American Trypanosomiasis remains a Neglected Tropical Disease (NTD).
Raquel Asunción Lima-Cordón, Sara Helms Cahan, Cai McCann, Patricia L Dorn, Silvia Andrade Justi, Antonieta Rodas, María Carlota Monroy, Lori Stevens   +7 more
doaj   +1 more source

Exploring Aspartate Transcarbamoylase: A Promising Broad‐Spectrum Target for Drug Development

ChemBioChem, Volume 26, Issue 7, April 1, 2025.
Pyrimidine biosynthesis is a pivotal process shared by both eukaryotes and prokaryotes. This review examines the applications and advantages of a series of inhibitors specifically designed to target aspartate transcarbamylase within the de novo biosynthetic pathway of the malarial parasite.
Siyao Chen, Queenie Mondile, XiaoChen Du, Chao Wang, Mayur Mukim, Carsten Wrenger, Alexander S. S. Dömling, Özlem Tastan Bishop, Matthew R. Groves   +8 more
wiley   +1 more source

Aspectos ecológicos da tripanossomíase americana: XI - domiciliação de Panstrongylus megistus e potencial enzoótico Ecological aspects of South American Trypanosomiasis: XI - domiciliation of Panstrongylus megistus and its enzootic potential

Revista de Saúde Pública, 1977
Foram observadas algumas características de populações locais de Panstrongylus megistus e de mamíferos domiciliados e silvestres. Confirmou-se o papel das matas residuais na permanência local da população triatomínica, bem como o caráter agrupado da ...
Oswaldo Paulo Forattini, Eduardo Olavo da Rocha e Silva, Octávio Alves Ferreira, Ernesto Xavier Rabello, Jair Lício Ferreira Santos, Anísio Ribeiro de Lima   +5 more
doaj   +1 more source

“Rapid-Impact Interventions”: How a Policy of Integrated Control for Africa's Neglected Tropical Diseases Could Benefit the Poor [PDF]

, 2005
Controlling seven tropical infections in Africa would cost just 40 cents per person per year, and would permanently benefit hundreds of millions of ...
Alan Fenwick, Commission for Africa, David H Molyneux, Peter J Hotez, The Lancet, The Lancet, UNAIDS, UNAIDS, What Works Working Group, What Works Working Group, World Bank, World Health Organization, World Health Organization, World Health Organization and Government of Mexico, World Health Organization, The Stop TB Partnership   +14 more
core   +6 more sources

Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
A series of isatinylhydantoin derivatives were synthesized and investigated for antileishmanial and antitrypanosomal activities in vitro and in vivo. The derivative 5 was identified with higher leishmanicidal activity than the clinical drug amphotericin B while 4b was uncovered as in vitro trypanocidal hit against T. congolense parasite.
Keamogetswe Sechoaro, Janine Aucamp, Christina Kannigadu, Helena D. Janse van Rensburg, Keisuke Suganuma, David D. N'Da   +5 more
wiley   +1 more source

Aspectos ecológicos da Tripanossomíase americana: VIII - Domiciliação de Panstrongylus megistus e sua presença extradomiciliar Ecological aspects of South American Trypanosomiasis: VIII - Local domiciled and wild pattern of Panstrongylus megistus

Revista de Saúde Pública, 1977
São apresentados os resultados iniciais de observações destinadas a evidenciar a presença de Panstrongylus megistus domiciliado e silvestre em uma mesma localidade.
Oswaldo Paulo Forattini, Octávio Alves Ferreira, Eduardo Olavo da Rocha e Silva, Ernesto Xavier Rabello   +3 more
doaj   +1 more source