Results 81 to 90 of about 9,868 (223)

Natural selection and genetic variation in a promising Chagas disease drug target: Trypanosoma cruzi trans-sialidase [PDF]

, 2017
Rational drug design is a powerful method in which new and innovative therapeutics can be designed based on knowledge of the biological target aiming to provide more efficacious and responsible therapeutics.
Gallant, Joseph P.
core   +1 more source

Exploring Aspartate Transcarbamoylase: A Promising Broad‐Spectrum Target for Drug Development

ChemBioChem, Volume 26, Issue 7, April 1, 2025.
Pyrimidine biosynthesis is a pivotal process shared by both eukaryotes and prokaryotes. This review examines the applications and advantages of a series of inhibitors specifically designed to target aspartate transcarbamylase within the de novo biosynthetic pathway of the malarial parasite.
Siyao Chen, Queenie Mondile, XiaoChen Du, Chao Wang, Mayur Mukim, Carsten Wrenger, Alexander S. S. Dömling, Özlem Tastan Bishop, Matthew R. Groves   +8 more
wiley   +1 more source

Review of Chagas Disease and Treatment Obstacles to Eradication [PDF]

, 2019
The World Health Organization and the Center for Disease Control reports Chagas disease, or American trypanosomiasis, as a major neglected tropical disease prevalent in 21 endemic Latin American countries.
Sherman, Emily
core   +1 more source

Infecção chagásica transfusional detectada no programa de controle da doença de Chagas no Estado de São Paulo (Brasil)

Revista de Saúde Pública
O sistema de vigilância da doença de Chagas no Estado de São Paulo propõe investigação minuciosa da presença de triatomíneos nos domicílios, que inclui o controle sorológico de populações moradoras em unidades domiciliares associadas a focos potenciais ...
Dalva Marli Valério Wandertey, Maria Esther de Carvalho, Ézio Mantegazza, Sueli Yasumaru, Luiz Carlos Barradas Barata   +4 more
doaj  

Aspectos ecológicos da tripanossomíase americana: XX - Desenvolvimento e ciclos anuais de colônias de Panstrongylus megistus em ecótopos artificiais, no ambiente peri e extradomiciliar Ecological aspects of South American trypanosomiasis: XX - Development and annual cycles of Panstrongylus megistus colonies in artificial ecotopes in the peri and extradomiciliary environment

Revista de Saúde Pública, 1984
Em colônias de Panstrongylus megistus, espontaneamente desenvolvidas em galinheiros experimentais, pôde-se observar as condições de desenvolvimento, variação e permanência de seus componentes.
Oswaldo Paulo Forattini, Octávio Alves Ferreira, Ernesto Xavier Rabello, José Maria Soares Barata, Jair Lício Ferreira Santos   +4 more
doaj   +1 more source

Aspectos ecológicos da tripanossomíase americana: IX - Variação e mobilidade de Panstrongylus megistus em ecótopos artificiais Ecological aspects of South American Trypanosomiasis: IX - Variation and mobility of Panstrongylus megistus in artificial ecotopes

Revista de Saúde Pública, 1977
Nas colônias de Panstrongylus megistus desenvolvidas espontaneamente em galinheiros experimentais foram observadas a variação, a permanência e a mobilidade de seus componentes.
Oswaldo Paulo Forattini, Octávio Alves Ferreira, Eduardo Olavo Rocha e Silva, Ernesto Xavier Rabello   +3 more
doaj   +1 more source

The role of Nucularia perrinii Batt. (Chenopodiaceae) in the camel-based Sahrawi social-ecological system [PDF]

, 2017
BACKGROUND: Pastoral social-ecological systems (SESs) are adaptive and complex systems rooted in the extensive exploitation of forage plants for livestock-based livelihoods and culture.
Antonello Di Nardo, Gabriele Volpato
core   +1 more source

Controle da hemoterapia e da doença de Chagas transfusional: 1988 e 1990

Revista de Saúde Pública
Com o objetivo de atualizar o estudo da situação da hemoterapia no Estado de São Paulo, Brasil foi realizado inquérito em 1990, comparando-o com outro realizado em 1988. Foram pesquisados 79 municípios, sendo que (77,4%) realizavam transfusões de sangue,
Dalva Marli Valério Wanderley, Thelma T. Gonzales, Maria Silvia C.A. Pereira, Rodrigo Delfino Nascimento, Helio Moraes-Souza   +4 more
doaj  

Molecular Identification of Trypanosoma cruzi Isolated from Wild Triatomines and Evaluation of Its Pathogenicity in Experimental Hosts

Parasitologia
Trypanosoma cruzi is a hemoflagellate protozoan and the causative agent of Chagas disease, also known as American trypanosomiasis. Transmission occurs through the feces of triatomine insects, its biological vector.
Ana Lucía Torres-Barajas, Melissa Paola Rincón-González, Sandra Luz Martínez-Hernández, Martín Humberto Muñoz-Ortega, David Ibarra-Martínez, Eduardo Sánchez-García, Erick López-Macías, Alberto Aguayo-Acosta, Joel Horacio Elizondo-Luevano, David Alejandro Hernández-Marín   +9 more
doaj   +1 more source

Morphological re-description and molecular identification of Tabanidae (Diptera) in East Africa [PDF]

, 2018
Biting flies of the family Tabanidae are important vectors of human and animal diseases across continents. However, records of Africa tabanids are fragmentary and mostly cursory.
Ciosi, Marc, Gitau, Joseph, Masiga, Daniel, Mugasa, Claire M., Ndungu, Nelly, Villinger, Jandouwe   +5 more
core   +2 more sources