Results 111 to 120 of about 45,242 (261)

Identification of New Anti‐Trypanosoma brucei Leads: An Integrated CRK12‐Guided Virtual Screen With Experimental Validation

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
An integrated computational‐experimental workflow enabled CRK12‐guided hit discovery against Trypanosoma brucei under limited structural and ligand data. The workflow of virtual screening and anti‐T. brucei bioassays identified 4 hit compounds, including three low‐micromolar leads (IC50 = 1.47, 0.81, and 1.33 μM). ABSTRACT Human African trypanosomiasis
Qin Li, Chenggong Fu, Jiayi Luo, Qianqian Zhang, Lingling Wang, Xiaomeng Liu, Jiayue Qiu, Xiaoqing Gong, Henry H. Y. Tong, Xiaojun Yao, Dehua Lai, Huanxiang Liu   +11 more
wiley   +1 more source

Host Immune Responses and Immune Evasion Strategies in African Trypanosomiasis

Frontiers in Immunology, 2019
Parasites, including African trypanosomes, utilize several immune evasion strategies to ensure their survival and completion of their life cycles within their hosts.
Chukwunonso Onyilagha, J. Uzonna
semanticscholar   +1 more source

Efficacy, safety, and dose of Pafuramidine, a new oral drug for treatment of first stage sleeping sickness, in a phase 2a clinical study and phase 2b randomized clinical studies [PDF]

, 2016
Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death.
Carol A. Olson (1807531), Patrick D Yeramian, Bilenge, Constantin Miaka Mia, Pascal Lutumba, Manuel, F, Sonja C Bernhard, Allen, James L., Mpanya, Alain, Alain Mpanya, Blum, Johannes, Lubaki, J P, Richard R Tidwell, Gabriele Pohlig, Constantin Miaka Mia Bilenge, Yeramian, Patrick D., Kazadi Kyanza Serge, Tidwell, R R, Thompson, Mark, Alfred Mpoo Mpoto, Bernhard, Sonja C., Tidwell, Richard R., Christian Burri (141244), Carol A Olson, Sonja C. Bernhard (1807537), Blaise Fungula Munungu, Bernhard, S C, James L Allen, Burri, Christian, Munungu, Blaise Fungula, Olson, Carol A., Francisco Manuel (1807528), Victor Kande Betu Ku Mesu, Constantin Miaka Mia Bilenge (1807513), Lutumba, P, Pohlig, G, Mark Thompson, Francisco Manuel, Blaise Fungula Munungu (1807519), Merolle, Ada, Lutumba, Pascal, Ada Merolle, Mpoto, Alfred Mpoo, Mesu, V K, Christian Burri, Jean-Pierre Fina Lubaki (1807546), Allen, J L, Josenando, Théophilo, Ada Merolle (1807540), Johannes Blum, Josenando, T, Lubaki, Jean-Pierre Fina, Gabriele Pohlig (267149), Pohlig, Gabriele, Bilenge, C M, Blum, J, Manuel, Francisco, Merolle, A, Mesu, Victor Kande Betu Ku, Yeramian, P D, Alfred Mpoo Mpoto (1807534), Serge, K K, Munungu, B F, Alain Mpanya (267142), Mark Thompson (533940), James L. Allen (1807522), Olson, C A, Johannes Blum (141240), Mpoto, A M, Victor Kande Betu Ku Mesu (1807510), Théophilo Josenando (1807516), Mpanya, A, Thompson, M, Patrick D. Yeramian (1807543), Richard R. Tidwell (148409), Théophilo Josenando, Burri, C, Jean-Pierre Fina Lubaki, Serge, Kazadi Kyanza, Kazadi Kyanza Serge (1807525), Pascal Lutumba (116142), Burri C, Mpoto AM, Mpanya A, Tidwell RR, Bilenge CM, Manuel F, Bernhard SC, Lubaki JP, Mesu VK, Allen JL, Pohlig G, Merolle A, Josenando T, Lutumba P, Serge KK, Munungu BF, Olson CA, Blum J, Yeramian PD, Thompson M   +99 more
core   +2 more sources

Bovines, buffers and barriers: A social scientific perspective on rewilding in the Kavango‐Zambezi Transfrontier Conservation Area

Conservation Science and Practice, Volume 8, Issue 9, September 2026.
Rewilding is often summarized with the three C's of Carnivores, Cores and Corridors. In this essay we propose a complementary perspective that focuses on the three B's of Bovines, Buffers and Barriers. This complementary perspective draws attention to rewilding as a social (rather than only ecological) challenge and is illustrated with insights from ...
Wisse Van Engelen, Paula Alexiou, Manuel Bollmann, Julia Brekl, Emilie Köhler, Léa Lacan, Hauke‐Peter Vehrs, Michael Bollig   +7 more
wiley   +1 more source

Trypanosomiasis and the brain

Parasitology, 2009
SUMMARYNeurological involvement following trypanosome infection has been recognised for over a century. However, there are still many unanswered questions concerning the mechanisms used by the parasite to gain entry to the CNS and the pathogenesis of the resulting neuroinflammatory reaction.
openaire   +2 more sources

Systematic Review Equine Trypanosomiasis

, 2022
Equid Trypanosomiasis: A systematic review of the global impact of a neglected tropical veterinary ...
Karelhia Cristina Garcia Alamo, David Sutton, Alexandra Raftery, Paul Capewell, Lauren Gummery, Dinesh Mohite   +5 more
core   +1 more source

Transmission of human African trypanosomiasis in the Komo-Mondah focus, Gabon

The Pan African Medical Journal, 2011
BACKGROUND: Knowledge about transmission of sleeping sickness in a given focus is of a great importance since it governs the efficacy and the cost-effectiveness of control strategy.
Lisette Kohagne Tongué, Paulette Mengue M’eyi, Raceline Gounoue Kamkuimo, Dramane Kaba, Francis J Louis, Rémy Mimpfoundi   +5 more
doaj   +1 more source

Generation of neuroinflammation in human African trypanosomiasis

Neurology: Neuroimmunology & Neuroinflammation, 2019
Human African trypanosomiasis (HAT) is caused by infection due to protozoan parasites of the Trypanosoma genus and is a major fatal disease throughout sub-Saharan Africa.
J. Rodgers, I. Steiner, P. Kennedy
semanticscholar   +1 more source

Efficacy and safety of pafuramidine versus pentamidine maleate for treatment of first stage sleeping sickness in a randomized, comparator-controlled, international phase 3 clinical trial [PDF]

, 2016
Sleeping sickness (human African trypanosomiasis [HAT]) is a neglected tropical disease with limited treatment options that currently require parenteral administration.
Carol A. Olson (1807531), Mintwo, Alain Fukinsia, Deo, Gratias Kambau Manesa, Sonja C. Bernhard, Bilenge, Constantin Miaka Mia, Patrick Mangoni N'tombe, Pierre Nsele Mutantu (1807651), Gabriele Pohlig, Patrick Mangoni N’tombe (1807627), Sonja C Bernhard, Alain Fukinsia Mintwo, N'tombe, Patrick Mangoni, N’tombe, Patrick Mangoni, Stephen Macharia (1807624), Kuikumbi, Florent Mbo, Mpanya, Alain, Richard R. Tidwell, Alain Mpanya, Augustin Kayeye Munungi, Blum, Johannes, Gratias Kambau Manesa Deo, Alain Fukinsia Mintwo (1807636), Gabriele Pohlig, Richard R Tidwell, Pierre Nsele Mutantu, Constantin Miaka Mia Bilenge, Gratias Kambau Manesa Deo (1807630), Patrick Mangoni N’tombe, Alfred Mpoo Mpoto, Bernhard, Sonja C., Augustin Kayeye Munungi (1807645), Tidwell, Richard R., Christian Burri (141244), Carol A Olson, Ndinga Dieyi Dituvanga, Sonja C. Bernhard (1807537), Ndinga Dieyi Dituvanga (1807648), Blaise Fungula Munungu, Burri, Christian, Munungu, Blaise Fungula, Olson, Carol A., Macharia, Stephen, Dituvanga, Ndinga Dieyi, Victor Kande Betu Ku Mesu, Constantin Miaka Mia Bilenge (1807513), Blaise Fungula Munungu (1807519), Mpoto, Alfred Mpoo, Christian Burri, Jose Ramon Franco, Jean-Pierre Fina Lubaki (1807546), Mutantu, Pierre Nsele, Franco, Jose Ramon, Johannes Blum, Lubaki, Jean-Pierre Fina, Gabriele Pohlig (267149), Pohlig, Gabriele, Jose Ramon Franco (1807639), Carol A. Olson, Mesu, Victor Kande Betu Ku, Alfred Mpoo Mpoto (1807534), Stephen Macharia, Alain Mpanya (267142), Amadeu Dala, Johannes Blum (141240), Dala, Amadeu, Munungi, Augustin Kayeye, Victor Kande Betu Ku Mesu (1807510), Florent Mbo Kuikumbi (1807633), Amadeu Dala (1807642), Richard R. Tidwell (148409), Florent Mbo Kuikumbi, Jean-Pierre Fina Lubaki, Burri C, Franco JR, Mpoto AM, Mpanya A, Deo GK, Munungi AK, Tidwell RR, Mutantu PN, Munungu BF, Mintwo AF, N'tombe PM, Bilenge CM, Dituvanga ND, Olson CA, Macharia S, Bernhard SC, Lubaki JP, Mesu VK, Dala A, Pohlig G, Blum J, Kuikumbi FM   +93 more
core   +1 more source

American trypanosomiasis and Chagas disease: Sexual transmission.

International Journal of Infectious Diseases, 2019
OBJECTIVE To contribute to the discussion on the research findings indicating the sexual transmission of American trypanosomiasis and Chagas disease in humans.
C. Gomes, Adriana B Almeida, A. Rosa, Perla F. Araújo, A. R. Teixeira   +4 more
semanticscholar   +1 more source