Results 91 to 100 of about 45,242 (261)
Advanced Science, Volume 13, Issue 59, 23 October 2026.Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa +11 more
wiley +1 more source
Tropical Medicine and Health, 2020 Background Tsetse flies are the cyclical vectors of both human and animal diseases. Kenya’s commitment to eradicate tsetse and trypanosomiasis dates to the 1980s through various control approaches which were spearheaded by the African Union.
Ferdinard Adungo +3 more
semanticscholar +1 more source
Molecules, 2022 Human protozoan diseases represent a serious health problem worldwide, affecting mainly people in social and economic vulnerability. These diseases have attracted little investment in drug discovery, which is reflected in the limited available ...
Paulo A. F. Pacheco, Maria M. M. Santos
doaj +1 more source
Biotechnology and Applied Biochemistry, Volume 73, Issue 5, Page 2457-2481, October 2026.ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva +8 more
wiley +1 more source
Melarsoprol Resistance in African Trypanosomiasis.
Trends in Parasitology, 2018 Arsenicals were introduced as monotherapies for the treatment of human African trypanosomiasis, or sleeping sickness, over 100 years ago. Toxicity has always been an issue but these drugs have proven to be both effective and quite durable. Unfortunately,
A. Fairlamb, D. Horn
semanticscholar +1 more source
Trypanocidal Essential Oils: A Review
Molecules, 2020 Trypanosomiases are diseases caused by parasitic protozoan trypanosomes of the genus Trypanosoma. In humans, this includes Chagas disease and African trypanosomiasis.
Mayara Castro de Morais +4 more
doaj +1 more source
VIEW, Volume 7, Issue 5, October 2026.Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley +1 more source
Monitoring the elimination of human African trypanosomiasis: Update to 2014
PLoS Neglected Tropical Diseases, 2017 Background The World Health Organization (WHO) has targeted the elimination of Human African trypanosomiasis (HAT) ‘as a public health problem’ by 2020.
J. Franco +7 more
semanticscholar +1 more source
Leptin Functions in Infectious Diseases
Frontiers in Immunology, 2018 Leptin, a pleiotropic protein has long been recognized to play an important role in the regulation of energy homeostasis, metabolism, neuroendocrine function, and other physiological functions through its effects on the central nervous system (CNS) and ...
Radheshyam Maurya +3 more
doaj +1 more source
Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis. [PDF]
PLoS Neglected Tropical Diseases, 2013 Genetic-modification strategies are currently being developed to reduce the transmission of vector-borne diseases, including African trypanosomiasis. For tsetse, the vector of African trypanosomiasis, a paratransgenic strategy is being considered: this ...
Jan Medlock +4 more
doaj +1 more source