Results 81 to 90 of about 27,075 (226)

In-hospital safety in field conditions of Nifurtimox Eflornithine Combination Therapy (NECT) for T. B. Gambiense Sleeping Sickness

, 2012
Trypanosoma brucei (T.b.) gambiense Human African trypanosomiasis (HAT; sleeping sickness) is a fatal disease. Until 2009, available treatments for 2(nd) stage HAT were complicated to use, expensive (eflornithine monotherapy), or toxic, and ...
Kisala, M, Schmid, C., Kisala, M., Mordt, O. V., Ismael Lumpungu, Mutanda, S, Mays Kisala, Kande, V, Nganzobo Pathou, Kuemmerle Andrea, Blum Johannes, Medard Ilunga, Nono Mubwa, Lumpungu Ismael, Mubwa Nono, Mordt Olaf Valverde, Schmid Caecilia, Mubwa, N, Blesson Severine, Wilfried Mutombo, Nganzobo, P., Mutombo Wilfried, Victor Kande, Mordt, O V, Tete Digas, Tete, D, Blesson, S, Kümmerle, A., Ilunga Medard, Schmid, C, Ilunga, M., Kuemmerle, A, Sylvain Mutanda, Ghabri, S, Ghabri, S., Andrea Kuemmerle, Lumpungu, I, Salah Ghabri, Kande, V., Johannes Blum, Lumpungu, I., Ghabri Salah, Blum, J, Digas Tete, Mubwa, N., Mutanda, S., Pathou Nganzobo, Ilunga, M, Caecilia Schmid, Tete, D., Nganzobo, P, Blum, J., Mutombo, W., Mutanda Sylvain, Kisala Mays, Blésson, S., Olaf Valverde Mordt, Severine Blesson, Kande Victor, Mutombo, W   +59 more
core   +1 more source

Evaluation of the in vitro [PDF]

, 2015
Trypanosomiasis is a neglected tropical disease with complex clinical manifestations, tedious diagnosis, and difficult treatments. The drugs available for the treatment of this endemic disease are old, expensive, and associated with other problems ...
Lai, Daowan, Marcel Kaiser, Proksch, Peter, Peter Proksch, Nwodo, Ngozi, Debbab, Abdesammed, Abdesammed Debbab, Okoye, Festus, Ngozi Nwodo, Kaiser, Marcel, Brun, Reto, Festus Okoye, Reto Brun, Daowan Lai   +13 more
core   +1 more source

Trypanosomiasis and the brain

Parasitology, 2009
SUMMARYNeurological involvement following trypanosome infection has been recognised for over a century. However, there are still many unanswered questions concerning the mechanisms used by the parasite to gain entry to the CNS and the pathogenesis of the resulting neuroinflammatory reaction.
openaire   +2 more sources

Tick‐borne pathogen interactions enhance transmission in cattle and ticks in Ogun, Nigeria

Ecosphere, Volume 17, Issue 5, May 2026.
Abstract Tick‐borne diseases (TBDs) pose a major public health concern in tropical regions, where co‐infections and pathogen interactions complicate disease control. Understanding how these interactions vary across vertebrate hosts and tick vectors, and their impact on disease transmission, is crucial for developing effective intervention strategies ...
Foluke Adedayo Akande, Elianne Piloto‐Sardiñas, Oyinkansola Suliat Fadiji, Akinkunmi Olusola Idowu, Olaitan O. Omitola, Timothy Bamgbose, Akinola Stephen Oluwole, Uwem Friday Ekpo, Benjamin Olukunle Fagbemi, Apolline Maitre, Salma Kaoutar Abdelali, Zbigniew Zając, Dasiel Obregon, Angélique Foucault‐Simonin, Adrian A. Díaz‐Sánchez, Alejandro Cabezas‐Cruz   +15 more
wiley   +1 more source

A molecular mechanism for eflornithine resistance in African trypanosomes [PDF]

, 2010
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma brucei.
Creek Darren, Watson David G., Burchmore, Richard J S, Barrett, M.P., Michael P. Barrett, Woods, DJ, Pui Ee Wong, Vincent, I.M., Darren Creek, Vincent, IM, Kamleh, M.A., Richard J S Burchmore, Wong, P.E., Kamleh, Mohammed A, Woods, Debra J, Creek, Darren, Richard J. S. Burchmore, Wong, PE, Vincent, Isabel M, Isabel M Vincent, Michael P Barrett, Isabel M. Vincent, Kamleh, MA, Watson, DG, Woods, D.J., Wong, Pui Ee, Woods Debra J., Mohammed A. Kamleh, David G. Watson, Barrett, Michael P, Creek, D., Barrett Michael P., Barrett, MP, Burchmore, R.J.S., Wong Pui Ee, David G Watson, Kamleh Mohammed A., Vincent Isabel M., Watson, David G, Burchmore, RJS, Creek, D, Watson, D.G., Debra J Woods, Debra J. Woods, Mohammed A Kamleh, Burchmore Richard J. S.   +45 more
core   +1 more source

Occurrence and Public Health Implications of Brucella Abortus and Antimicrobial Residues in Raw Cow Milk in Bukombe District, Tanzania

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Poor husbandry practices in Bukombe District accelerate diseases in livestock and indiscriminate uses of antimicrobials. Cow abortions, raw cow placenta and aborted fetuses feeding dogs, communal grazing and watering and introduction of new animals predict brucellosis in the herd.
Makoye Mhozya, Mwalimu Julius K, Hezron Emmanuel Nonga   +2 more
wiley   +1 more source

Insights into the Control and Management of Human and Bovine African Trypanosomiasis in Zambia between 2009 and 2019—A Review

Tropical Medicine and Infectious Disease, 2020
Tsetse transmitted trypanosomiasis is a fatal disease commonly known as Nagana in cattle and sleeping sickness in humans. The disease threatens food security and has severe economic impact in Africa including most parts of Zambia.
Gloria M. Mulenga, Lars Henning, Kalinga Chilongo, Chrisborn Mubamba, Boniface Namangala, Bruce Gummow   +5 more
doaj   +1 more source

What Is Your Diagnosis? Blood Smear From a North American Beaver (Castor canadensis)

Veterinary Clinical Pathology, EarlyView.
Lilani Munasinghe, Shanika Kurukulasuriya, Tracy Yuen, Dennilyn Parker, Betty Lockerbie   +4 more
wiley   +1 more source

In Vitro Antitrypanosomal and Antibacterial Activity of Aqueous, Hydroethanolic and Ethanolic Extracts of Rumex obtusifolius L. Leaf and Root

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 5, May 2026.
ABSTRACT Plant extracts are an important raw material for the development of new drugs. Rumex obtusifolius L., popularly known as ‘bitter dock’, has significant pharmacological properties. This study evaluated the in vitro antitrypanosomal activity of aqueous, hydroethanolic and ethanolic extracts from the leaf and roots of R. obtusifolius L.
Gabriela K. Borges, Gabriella B. Das Neves, Letícia Reichardt, Ubirajara Maciel da Costa, Luiz C. Miletti, Amanda L. Bastos‐Pereira   +5 more
wiley   +1 more source

Human African trypanosomiasis presenting at least 29 years after infection--what can this teach us about the pathogenesis and control of this neglected tropical disease? [PDF]

, 2014
No abstract ...
Francesco Checchi, Sarah Lawrence, Angela Vincent, Eligar, Vinay, Capewell, P, Pickrell, William Owen, William Owen Pickrell, Annette MacLeod, Checchi, Francesco, Shumonta Quaderi, Richard Walters, Darshan Sudarshi, Paul Capewell, Michael Brown, Brown, Michael, Alice Walker, MacLeod, Annette, Sudarshi, D, Sudarshi, Darshan, Walters, R, Eligar, V, Walters, Richard, Lawrence, Sarah, Walker, Alice, Caroline Clucas, Vincent, Angela, Vinay Eligar, Clucas, Caroline, Checchi, F, Macleod, A, Vincent, A, Capewell, Paul, Walker, A, Clucas, C, Quaderi, Shumonta, Lawrence, S, Quaderi, S, Brown, M, Pickrell, WO   +38 more
core   +1 more source